Study Summary
This trialwill study a new medicine combo to treat sickle cell disease. Participants will get NDec, placebo, or Hydroxyurea, and take capsules twice weekly for a year.
- Sickle Cell Disease
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 14 Secondary · Reporting Duration: From baseline (week 0) to week 52
Trial Safety
Safety Progress
Trial Design
6 Treatment Groups
HU-active - HU
1 of 6
HU-active - NDec plus placebo
1 of 6
HU-active - NDec plus NDec
1 of 6
HU-non-eligible - NDec plus NDec
1 of 6
HU-non-eligible - NDec plus placebo
1 of 6
HU-non-eligible - Placebo plus placebo
1 of 6
Active Control
Experimental Treatment
Non-Treatment Group
84 Total Participants · 6 Treatment Groups
Primary Treatment: HU-active - NDec plus NDec · Has Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 11 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Has the FDA given authorization for HU-active - NDec plus NDec?
"The safety of HU-active - NDec plus NDec was measured to be a 2 on the 1-3 scale as this clinical trial is in Phase 2, indicating that there are some studies affirming its security but no data yet confirming efficacy." - Anonymous Online Contributor
How many individuals are receiving treatment as part of this clinical trial?
"Affirmative. Content from clinicaltrials.gov suggests that this research project, which was initially published on July 7th 2022, is currently recruiting trial subjects. Approximately 84 individuals are envisioned to be recruited across 17 different medical sites." - Anonymous Online Contributor
Is enrollment still taking place for this clinical examination?
"Per the data available on clinicaltrials.gov, this medical investigation is open for recruitment. It was originally posted on July 7th 2022 and most recently amended a month ago - November 10th 2022." - Anonymous Online Contributor
Are there any North American sites involved in the execution of this trial?
"This medical trial is taking place in 17 different sites, including Aurora, Oklahoma City and Philadelphia. To minimize necessary travel for enrolled patients, it's advised to register with the closest clinic." - Anonymous Online Contributor