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Load Modulation for Cerebral Palsy

N/A

Waitlist Available

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Typically developing with no diagnosed medical conditions that affect movement, OR with a diagnosis of bilateral cerebral palsy (including diplegia, tetraplegia, and quadriplegia) where the lower limbs are more affected than the upper limbs

Aged 5 years to 19 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at baseline and each loading level; during entirety of the stepping trial, from initial lift-off to final contact onto the single platform.

Awards & highlights

Study Summary

This trial looks at children with two-sided cerebral palsy to see how their legs are affected when they take steps.

Who is the study for?

This trial is for children and teenagers aged 5 to 19 who can step up independently, with or without help from devices. It's specifically for those with bilateral cerebral palsy where legs are more affected than arms, but also includes typically developing individuals without movement-affecting conditions.Check my eligibility

What is being tested?

The study is exploring how load modulation affects stepping tasks in participants with bilateral cerebral palsy. Researchers want to understand the lower limb impairments during these activities.See study design

What are the potential side effects?

Since this trial involves physical tasks rather than medication, side effects may include muscle fatigue or discomfort related to the exercise involved in the stepping tests.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I either have no medical conditions affecting movement or have cerebral palsy with my legs more affected than my arms.

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I am between 5 and 19 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at baseline and each loading level; during entirety of the stepping trial, from initial lift-off to final contact onto the single platform.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at baseline and each loading level; during entirety of the stepping trial, from initial lift-off to final contact onto the single platform.

This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline and each loading level; during entirety of the stepping trial, from initial lift-off to final contact onto the single platform. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Joint biomechanics (ankle)

Joint biomechanics (hip)

Joint biomechanics (knee)

+1 more

Secondary outcome measures

Muscle activations (ankle)

Muscle activations (hip)

Muscle activations (knee)

Trial Design

1Treatment groups

Experimental Treatment

Group I: load modulationExperimental Treatment1 Intervention

Participants will experience different body weight loading conditions - with body weight added by a weighted vest or removed using the ZeroG overhead harness.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor

1,585 Previous Clinical Trials

917,201 Total Patients Enrolled

4 Trials studying Cerebral Palsy

499 Patients Enrolled for Cerebral Palsy

Media Library

load modulation Clinical Trial Eligibility Overview. Trial Name: NCT04957277 — N/A

Cerebral Palsy Research Study Groups: load modulation

Cerebral Palsy Clinical Trial 2023: load modulation Highlights & Side Effects. Trial Name: NCT04957277 — N/A

load modulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04957277 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment have any age restrictions, particularly for individuals over sixty years of age?

"The minimum age requirement for enrolment into this medical study is 5 years old and the maximum cap is 19. At the moment, there are 148 trials designed for minors and 71 studies orientated towards octogenarians or older."

Answered by AI

How many participants are involved in this research endeavor?

"Indeed, information accessibly on clinicaltrials.gov affirms that this trial is actively recruiting participants; it was initially published on May 19th 2021 and subsequently refreshed on June 30th 2021. At present, the protocol requires enrolment of 30 volunteers from one research site."

Answered by AI

Are there any openings to join this research endeavor?

"Indeed, the trial's presence on clinicaltrials.gov reveals its active recruitment status as of June 30th 2021 - following its initial posting 19 May 2021."

Answered by AI

Is it permissible for me to join this clinical experiment?

"30 children and young adults, aged 5 to 19 years old, with a diagnosis of cerebral palsy (including diplegia, tetraplegia, or quadriplegia) whose lower limbs are more affected than the upper limbs may enrol in this trial. Additionally, they must be able to ascend independently using any required assistive devices. Alternatively participants without movement impairing medical conditions but who still fit within the age range will also be considered."

Answered by AI

Recent research and studies

Gait & PostureJournal

Sagittal and Frontal Lower Limb Joint Moments During Stair Ascent and Descent in Young and Older Adults

Novak, A.C., and B. Brouwer. 2011. “Sagittal and Frontal Lower Limb Joint Moments During Stair Ascent and Descent in Young and Older Adults”. Gait & Posture. Elsevier BV. doi:10.1016/j.gaitpost.2010.09.024.

Physical TherapyJournal

Association Between Characteristics of Locomotion and Accomplishment of Life Habits in Children with Cerebral Palsy

Lepage, Céline, Luc Noreau, and Paul-Marie Bernard. 1998. “Association Between Characteristics of Locomotion and Accomplishment of Life Habits in Children with Cerebral Palsy”. Physical Therapy. Oxford University Press (OUP). doi:10.1093/ptj/78.5.458.

Developmental Medicine & Child NeurologyJournal

Selective Motor Control in Spastic Cerebral Palsy

ROSE, JESSICA. 2009. “Selective Motor Control in Spastic Cerebral Palsy”. Developmental Medicine & Child Neurology. Wiley. doi:10.1111/j.1469-8749.2009.03401.x.

Developmental Medicine & Child NeurologyJournal