tDCS + CILT for Primary Progressive Aphasia

University of Pennsylvania, Philadelphia, PA
Primary Progressive AphasiaTranscranial Direct Current Stimulation (tDCS) - Device
45 - 80
All Sexes

Study Summary

This trial will study the effects of transcranial direct current stimulation (tDCS) on people with primary progressive aphasia, a degenerative neurological disorder that affects language abilities. The study will use tDCS paired with modified constraint-induced language therapy (mCILT). Language testing and brain imaging will be repeated after treatment to study changes in language performance and brain activity.

Eligible Conditions
  • Primary Progressive Aphasia

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Baseline to 24 weeks

Baseline to 24 weeks
Western Aphasia Battery (WAB)

Trial Safety

Phase-Based Safety

1 of 3

Trial Design

2 Treatment Groups

1 of 2
Sham tDCS + CILT
1 of 2

Active Control

Non-Treatment Group

62 Total Participants · 2 Treatment Groups

Primary Treatment: tDCS + CILT · Has Placebo Group · N/A

tDCS + CILTActiveComparator Group · 2 Interventions: Transcranial Direct Current Stimulation (tDCS), Modified Contraint-Induced Language Therapy (mCILT) · Intervention Types: Device, Behavioral
Sham tDCS + CILTShamComparator Group · 2 Interventions: Sham tDCS, Modified Contraint-Induced Language Therapy (mCILT) · Intervention Types: Device, Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to 24 weeks

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
1,899 Previous Clinical Trials
41,218,031 Total Patients Enrolled
Roy Hamilton, MSPrincipal InvestigatorUniversity of Pennsylvania

Eligibility Criteria

Age 45 - 80 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You need to be able to speak English fluently as your first language.

Frequently Asked Questions

For whom is this investigation best suited?

"This clinical trial is looking for 62 individuals aged between 45 and 80 who are affected by aphasia. In particular, candidates must meet the criteria of either semantic variant (svPPA) or non-fluent/agrammatic variant (naPPA) Primary Progressive Aphasia." - Anonymous Online Contributor

Unverified Answer

What is the scope of participation in this clinical investigation?

"Correct. According to, the trial which was advertised on December 1st 2020 is actively recruiting participants at this moment in time. This study requires 62 volunteers from a single location for its completion." - Anonymous Online Contributor

Unverified Answer

Is there still an opportunity for enrolment in this research study?

"Affirmative. holds the details of this medical trial, which was initially posted on December 1st 2020 and recently modified on January 28th 2022, showing that it is actively recruiting 62 patients from a single site." - Anonymous Online Contributor

Unverified Answer

Does this research endeavor accept participants who have reached the age of 55 or greater?

"This clinical trial is accepting patients who have surpassed their mid-forties yet are still under eighty years old." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.