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tDCS

Active tDCS plus Speech-Language Therapy for Primary Progressive Aphasia

N/A

Waitlist Available

Led By Argye E Hillis, MD, MS

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, and 4-7 weeks after treatment begins

Awards & highlights

Study Summary

This trial investigates whether tDCS paired with language therapy can help improve verb usage for people with PPA, a debilitating disorder that gradually robs patients of their language skills.

Eligible Conditions

Primary Progressive Aphasia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, and 4-7 weeks after treatment begins

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, and 4-7 weeks after treatment begins

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and 4-7 weeks after treatment begins for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery (OANB)

Secondary outcome measures

Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery

Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery

Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Untrained Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active tDCS plus Speech-Language TherapyExperimental Treatment2 Interventions

Active tDCS will be applied at the beginning of 45min speech-language therapy session and will last for 20 min. Language therapy will be verb naming therapy in a sentence context. This will be followed by sham tDCS plus speech-language therapy after a 2 month washout period.

Group II: Sham plus Speech-Language TherapyPlacebo Group2 Interventions

Sham tDCS will be applied at the beginning of 45min speech-language therapy session. Language therapy will be oral and written naming. Language therapy will be verb naming therapy in a sentence context. This will be followed by active tDCS plus speech-language therapy after a 2 month washout period.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Active tDCS plus Speech-Language Therapy

2018

N/A

~10

Sham tDCS plus Speech-Language Therapy

2018

N/A

~10

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,259 Previous Clinical Trials

14,820,645 Total Patients Enrolled

Argye E Hillis, MD, MSPrincipal InvestigatorJohns Hopkins University

Shannon M Sheppard, PhDPrincipal InvestigatorJohns Hopkins University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals have the capacity to participate in this experiment?

"Correct. According to the information available on clinicaltrials.gov, this research endeavour is currently recruiting individuals for participation. The study was initially posted in October of 2018 and last revised in January 2022; it aims to enrol 50 patients from one medical site."

Answered by AI

Does this trial accept individuals of all ages, or are there age restrictions?

"This trial is recruiting individuals who are of the age 18 and below 100 years old."

Answered by AI

Is there still availability for enrolment in this research endeavor?

"Clinicaltrials.gov data indicates that this experiment is still recruiting participants, with the initial posting on October 10th 2018 and the most recent modifications happening on January 19th 2022."

Answered by AI

Am I eligible to be part of this clinical experiment?

"The trial is seeking 50 individuals with primary progressive aphasia aged between 18 and 100. In order to be eligible for the study, participants must have consent capacity or an assigned legal representative; meet the PPA criteria and display naming deficits; as well as fall within the stated age range."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy

2018. "Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03728582.