Active TMS for Aphasia

Phase-Based Progress Estimates
University of Pennsylvania, Philadelphia, PAAphasiaActive TMS - Device
18 - 80
All Sexes
What conditions do you have?

Study Summary

This trial will study the effects of combining Transcranial Magnetic Stimulation (TMS) with Constraint Induced Language Therapy (CILT) in subjects with chronic aphasia. The primary outcome measure will be change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 6-months post-treatment

6-months post-treatment
Change in PNT
Change in WAB-AQ

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Active TMS
1 of 2
Sham TMS
1 of 2

Active Control

Non-Treatment Group

83 Total Participants · 2 Treatment Groups

Primary Treatment: Active TMS · Has Placebo Group · Phase 2

Active TMSActiveComparator Group · 2 Interventions: Active TMS, CILT · Intervention Types: Device, Behavioral
Sham TMSShamComparator Group · 2 Interventions: Sham TMS, CILT · Intervention Types: Device, Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6-months post-treatment

Who is running the clinical trial?

H. Branch CoslettLead Sponsor
National Institutes of Health (NIH)NIH
2,472 Previous Clinical Trials
24,591,073 Total Patients Enrolled
8 Trials studying Aphasia
1,689 Patients Enrolled for Aphasia
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
292 Previous Clinical Trials
175,732 Total Patients Enrolled
35 Trials studying Aphasia
2,535 Patients Enrolled for Aphasia
H. Branch Coslett, MD4.04 ReviewsPrincipal Investigator - University of Pennsylvania
University of Pennsylvania
2 Previous Clinical Trials
54 Total Patients Enrolled
1 Trials studying Aphasia
24 Patients Enrolled for Aphasia

Eligibility Criteria

Age 18 - 80 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You had a stroke at least 6 months ago.

Frequently Asked Questions

May I join the research endeavor?

"Eligibility requirements for this medical trial state that participants must be diagnosed with aphasia and between the ages of 18-80. A maximum of 83 patients may join the study." - Anonymous Online Contributor

Unverified Answer

Has Transcranial Magnetic Stimulation been validated by the FDA?

"As this is a Phase 2 Clinical Trial, with minimal evidence for efficacy and some data to support safety, our team at Power has assigned Active TMS a score of 2." - Anonymous Online Contributor

Unverified Answer

Is the age of consent sufficient to qualify for enrollment in this research?

"This research is looking for participants who are aged 18 years and above, but below 80." - Anonymous Online Contributor

Unverified Answer

How many participants are being accepted into this research endeavor?

"Affirmative. data suggests that participant recruitment for this medical trial, which commenced on March 28th 2019, is ongoing. This project seeks 83 test subjects from a single site." - Anonymous Online Contributor

Unverified Answer

Are there any remaining vacancies in this experiment for participants?

"The website shows that this research is currently recruiting participants. The trial was initially launched on March 28th 2019 and its details were recently updated on August 15th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.