Stroke Subjects for Stroke

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Mayo Clinic Rochester, Rochester, MN
Stroke+6 More
Transcranial Direct Current Stimulation - Procedure
Eligibility
18+
All Sexes
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Study Summary

This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational devices repetitive TMS or transcranial direct current stimulation (tDCS).

Eligible Conditions

  • Healthy Subjects (HS)
  • Acquired Brain Injury
  • Stroke
  • Traumatic Brain Injury (TBI)

Treatment Effectiveness

Study Objectives

5 Primary · 0 Secondary · Reporting Duration: Baseline, 3 months

Baseline
EEG and TMS-EEG functional connectivity
MRI based structural connectivity.
Baseline, 3 months
Change in Modified Rankin Scale
Change in Western Aphasia Battery (WAB) Aphasia (AQ) and Language Quotients (LQ)
Change in neurological outcome (NIHSS)

Trial Safety

Trial Design

2 Treatment Groups

Stroke Subjects
1 of 2
Non-Stroke Subjects
1 of 2
Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Stroke Subjects · No Placebo Group · N/A

Stroke SubjectsExperimental Group · 3 Interventions: Transcranial Direct Current Stimulation, Electroencephalogram, Transcranial Magnetic Stimulation · Intervention Types: Procedure, DiagnosticTest, Procedure
Non-Stroke SubjectsExperimental Group · 3 Interventions: Transcranial Direct Current Stimulation, Electroencephalogram, Transcranial Magnetic Stimulation · Intervention Types: Procedure, DiagnosticTest, Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Direct Current Stimulation
2014
Completed Phase 3
~1150
Electroencephalogram
2012
N/A
~90
Transcranial Magnetic Stimulation
2011
Completed Phase 4
~580

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 3 months

Trial Background

Zafer Keser, Principal Investigator
Principal Investigator
Mayo Clinic
Closest Location: Mayo Clinic Rochester · Rochester, MN
Photo of Mayo Clinic Rochester  1Photo of Mayo Clinic Rochester  2Photo of Mayo Clinic Rochester  3
2005First Recorded Clinical Trial
2 TrialsResearching Stroke
156 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.