TMS for Bipolar Mood Disorders
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether transcranial magnetic stimulation (TMS) can help individuals with bipolar disorder manage their emotions more effectively. Researchers aim to determine if TMS, a non-invasive technique using magnetic fields to stimulate the brain, can enhance mood regulation in those with bipolar disorder. The trial includes two groups: individuals diagnosed with bipolar I disorder who have remained stable on psychiatric medication for at least a month, and healthy individuals without major psychiatric illnesses. Participants must not have recently changed psychiatric medications or possess certain metal implants in their head or neck. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to new methods for managing bipolar disorder.
What prior data suggests that this technique is safe for individuals with bipolar disorder?
Research has shown that transcranial magnetic stimulation (TMS) is generally safe for individuals with mood disorders, such as bipolar disorder. Studies have found that most people tolerate TMS well, experiencing no major issues. Some may feel slight scalp discomfort or a mild headache, but serious side effects are rare.
The FDA has approved TMS for treating major depression, and researchers are also exploring its use for bipolar disorder. Experts believe it could be helpful and safe for individuals with bipolar disorder as well. Overall, TMS has been tested in numerous studies with positive safety results, making it a promising treatment option for consideration.12345Why are researchers excited about this trial?
Transcranial Magnetic Stimulation (TMS) is unique because it offers a non-invasive way to potentially stabilize mood in individuals with Bipolar 1 Disorder. Unlike traditional treatments such as mood stabilizers and antipsychotic medications, TMS uses magnetic fields to stimulate specific areas of the brain linked to mood regulation. Researchers are excited about TMS because it could provide a faster onset of relief with fewer side effects compared to medication, which often requires weeks to take effect and can have significant side effects. This innovative approach targets the brain directly, which may lead to more precise and rapid improvements in mood symptoms.
What evidence suggests that TMS is effective for improving emotion regulation in individuals with bipolar disorder?
Research has shown that transcranial magnetic stimulation (TMS) could help treat bipolar disorder, particularly during depressive episodes. One study found that 87.1% of patients with bipolar depression responded positively to TMS, and 74.2% experienced significant symptom improvement, reaching remission. TMS is already approved for major depression and is gaining attention for its potential benefits in bipolar disorder. Although some studies have mixed results, many patients experience positive outcomes, and the treatment is popular due to its non-invasive nature. This trial will administer TMS to participants to evaluate its effectiveness specifically for bipolar mood disorders.12467
Who Is on the Research Team?
Kristen K Ellard, PhD
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
This trial is for adults aged 18-50 with bipolar I disorder who are not in a current mood episode and have been on stable psychiatric medication for at least one month. Participants should not have metal implants sensitive to magnets near their head or neck, no history of seizures, neurosurgery, ECT or TMS treatment within three months, and no active substance use disorders.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive transcranial magnetic stimulation (TMS) to improve emotion regulation
Follow-up
Participants are monitored for changes in emotion regulation tasks post-TMS
What Are the Treatments Tested in This Trial?
Interventions
- TMS
TMS is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator