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TMS Targeting Methods for Depression (XRnav Trial)

N/A
Waitlist Available
Led By Jennifer A McNab, PhD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 9 weeks
Awards & highlights

XRnav Trial Summary

This trial will test whether using a mixed reality device to target transcranial magnetic stimulation (TMS) is more effective than using scalp measurements or a commercial neuronavigation system.

Who is the study for?
This trial is for adults aged 18-75 with treatment-resistant depression who are prescribed transcranial magnetic stimulation (TMS) therapy. They must be MRI-compatible, meaning no metal in the body and able to complete screening at specific centers. Excluded are those with neurological disorders, pacemakers or certain implants, and a history of substance abuse.Check my eligibility
What is being tested?
The study tests if using mixed reality devices can improve TMS targeting for treating depression compared to traditional scalp measurements or commercial neuronavigation systems. It aims to see if this method reduces setup time and is practical in clinical settings.See study design
What are the potential side effects?
While not explicitly stated here, common side effects of TMS may include headache, scalp discomfort at the site of stimulation, tingling or spasms of facial muscles.

XRnav Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~9 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 9 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of participants with response to TMS

XRnav Trial Design

2Treatment groups
Active Control
Group I: No neuronavigationActive Control1 Intervention
For this group, the stimulation location for repetitive transcranial stimulation treatment is estimated by the clinician via scalp measurements.
Group II: Mixed reality neuronavigationActive Control2 Interventions
For this group, the stimulation location for repetitive transcranial stimulation treatment is estimated by the clinician via a mixed reality neuronavigation device.

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,386 Previous Clinical Trials
17,333,948 Total Patients Enrolled
105 Trials studying Depression
93,674 Patients Enrolled for Depression
Jennifer A McNab, PhDPrincipal InvestigatorStanford University

Media Library

Mixed reality neuronavigation (Device) Clinical Trial Eligibility Overview. Trial Name: NCT04730180 — N/A
Depression Research Study Groups: No neuronavigation, Mixed reality neuronavigation
Depression Clinical Trial 2023: Mixed reality neuronavigation Highlights & Side Effects. Trial Name: NCT04730180 — N/A
Mixed reality neuronavigation (Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04730180 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still room for participants in this research endeavor?

"The records in clinicaltrials.gov show that this particular trial is no longer recruiting patients, with the last update occurring on 4th May 2021. However, there are a plethora of other trials currently seeking participants to join their study - 1,286 at present count."

Answered by AI

Who has the eligibility to join in this research endeavor?

"This clinical trial is in search of 60 individuals aged 18 to 75 who currently have depression. In addition, the prospective candidates must be male or female and prescribed a course of rTMS therapy for treatment-resistant depression."

Answered by AI

Is this clinical experimentation open to persons of legal age?

"This medical trial's requirements for inclusion necessitate that applicants must be aged 18 to 75. For those under the age of 18, there are 191 related studies available and 961 for seniors over 65 years old."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
Stanford University
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Comparison of Targeting Methods for Transcranial Magnetic Stimulation Treatment of Depression
Jennifer McNab 2024. "Comparison of Targeting Methods for Transcranial Magnetic Stimulation Treatment of Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04730180.
All > Transcranial Magnetic Stimulation
~40 spots leftby Jul 2026
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