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Platelet-rich Plasma
PRP vs Steroid Injections for Lower Back Pain
N/A
Recruiting
Led By Miriam Peckham, MD
Research Sponsored by University of Utah
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adult (>18 y/o) males and females referred for therapeutic injection to the investigators spine interventional service by a physiatrist or pain anesthesiologist with a clinical diagnosis of SIJ pain confirmed by history
50% or greater reduction in pain by a diagnostic anesthetic block using no more than 1.5 cc 2% lidocaine performed under imaging guidance by a pain interventionalist (PM&R, Pain Anesthesia, or Neuroradiology Spine Intervention)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change between baseline and 3-months post-intervention
Awards & highlights
Study Summary
This trial looks at whether PRP or steroid/anesthetic injections work better for lower back pain relief.
Who is the study for?
This trial is for adults with chronic sacroiliac joint pain, confirmed by a specific diagnostic block and lasting at least 6 weeks. Participants must have significant pain that isn't caused by other conditions like infections or inflammatory diseases. Pregnant individuals, those on immunosuppressants, or who've had SIJ steroid treatment in the last 6 months can't join.Check my eligibility
What is being tested?
The study is testing if platelet-rich plasma (PRP) injections are more effective than steroid/anesthetic injections for treating sacroiliac joint pain. Patients will receive one of these treatments directly into the affected joint to compare their effectiveness.See study design
What are the potential side effects?
Potential side effects may include temporary increase in pain, bleeding or bruising at the injection site, infection risks, and allergic reactions to components of PRP or steroids.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am an adult with confirmed SIJ pain referred for a therapeutic injection.
Select...
My pain was reduced by half or more after a small, targeted numbing shot.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ change between baseline and 3-months post-intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change between baseline and 3-months post-intervention
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Numeric Rating Scale
Secondary outcome measures
Functional testing
Modified Oswestry Disability Questionnaire
Opiate/pain medication usage questionnaire
+1 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Platelet-rich PlasmaExperimental Treatment1 Intervention
Patients will receive an intra-articular injection 3 mL of autologous platelet-rich plasma in the sacroiliac joint.
Group II: Steroid/AnestheticActive Control1 Intervention
Patients will receive an intra-articular injection 40 mg Depo-medrol mixed with 2 mL 0.25% bupivicaine in the sacroiliac joint.
Find a Location
Who is running the clinical trial?
University of UtahLead Sponsor
1,099 Previous Clinical Trials
1,778,639 Total Patients Enrolled
Radiological Society of North AmericaOTHER
25 Previous Clinical Trials
1,769 Total Patients Enrolled
Miriam Peckham, MDPrincipal InvestigatorUniversity of Utah
Frequently Asked Questions
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