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TMS + EEG for Brain Mapping in Healthy Subjects

N/A
Waitlist Available
Led By Fred Barrett
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up session 1 and session 2 with one week between sessions
Awards & highlights

Study Summary

This trial will investigate if three types of transcranial magnetic stimulation (TMS), when used to measure electroencephalography (EEG), can be reliably repeated across five brain regions in healthy volunteers.

Who is the study for?
This trial is for healthy adults aged 18-65 who speak English and can consent. Participants must not have a history of neurological issues, serious medical conditions, or be pregnant. They should be under 350 lbs to fit in the TMS/EEG chair and willing to remove any metal from their head area.Check my eligibility
What is being tested?
The study tests how reliable transcranial magnetic stimulation (TMS) is when measuring brain responses with EEG. It compares single pulse, inhibitory, excitatory TMS protocols over five brain areas using individualized and standard targeting methods.See study design
What are the potential side effects?
Potential side effects may include discomfort at the stimulation site, headache, lightheadedness or seizures (very rare). There might also be temporary hearing changes due to the loud 'click' during TMS.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~session 1 and session 2 with one week between sessions
This trial's timeline: 3 weeks for screening, Varies for treatment, and session 1 and session 2 with one week between sessions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Comparison of interclass correlation coefficients (ICC) of TMS Evoked Potential amplitudes, as measured by EEG, between individualized and non-individualized targeting approaches
Comparison of interclass correlation coefficients (ICC) of TMS Evoked Potential amplitudes, as measured by EEG, between single and paired-pulse TMS protocols

Trial Design

1Treatment groups
Experimental Treatment
Group I: All participantsExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Concurrent transcranial magnetic stimulation and electroencephalogram
2022
N/A
~30

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,259 Previous Clinical Trials
14,820,629 Total Patients Enrolled
Fred BarrettPrincipal InvestigatorJohns Hopkins University

Media Library

All participants Clinical Trial Eligibility Overview. Trial Name: NCT05665634 — N/A
Healthy Subjects Research Study Groups: All participants
Healthy Subjects Clinical Trial 2023: All participants Highlights & Side Effects. Trial Name: NCT05665634 — N/A
All participants 2023 Treatment Timeline for Medical Study. Trial Name: NCT05665634 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants aged twenty or over eligible for this research study?

"As outlined in the requirements for inclusion, applicants must be between 18 and 65 years of age."

Answered by AI

Is there still the potential for enrolment in this investigation?

"Patients are currently being sought for this clinical trial, as shown on the records hosted at clinicaltrials.gov. This data was initially posted in December 2nd 2022 and has since been updated on December 19th of the same year."

Answered by AI

How many test subjects have enrolled in this experiment?

"Affirmative. According to the details on clinicaltrials.gov, this medical experiment is actively recruiting patients since it was first posted on December 2nd 2022 and last updated on December 19th 2022. There are 30 participants that need to be found at one location."

Answered by AI

For whom is this scientific research available?

"This clinical trial is seeking 30 participants within the 18-65 years old age range who are medically and psychiatrically sound. Furthermore, prospective test subjects should be adept in English for consent purposes and willing to remove any metallic or magnetized objects that may interfere with data collection from their person."

Answered by AI

Who else is applying?

What state do they live in?
Maryland
What site did they apply to?
Johns Hopkins Medicine
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Johns Hopkins Medicine: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Concurrent TMS and EEG Pilot Study
2022. "Concurrent TMS and EEG Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05665634.
~10 spots leftby Apr 2025
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