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Aerobic Exercise + Speech Therapy for Aphasia

N/A
Waitlist Available
Led By Elizabeth Galletta, MD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Independent in walking (with or without assistive device)
No significant musculo-skeletal problems from conditions other than stroke
Must not have
Inability to perform required exercises due to medical, musculo-skeletal, or neurological problems
Progressive stroke (primary progressive aphasia diagnosis)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 weeks
Awards & highlights

Summary

This trial is testing whether adding aerobic exercise to speech therapy can help people with aphasia (trouble speaking) improve more.

Who is the study for?
This trial is for English-speaking adults who have mild to moderate aphasia from a past stroke (at least 9 months ago) and can walk independently. They must be medically stable with no history of heart attack, significant musculoskeletal issues unrelated to the stroke, or multiple strokes. People with other neurological conditions, current severe psychiatric illnesses, substance addiction, or involvement in another trial cannot participate.Check my eligibility
What is being tested?
The study aims to see if combining aerobic exercise with speech therapy helps people with aphasia more than speech therapy alone. Participants will undergo language treatment sessions paired with physical activity and are monitored for improvements in their communication abilities.See study design
What are the potential side effects?
Since this trial involves common activities like exercise and language therapy, side effects may include typical exercise-related discomforts such as muscle soreness or fatigue. However, participants are screened by doctors beforehand to minimize risks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can walk on my own, with or without help from a device.
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I don't have major muscle or bone issues not caused by a stroke.
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I have never had a heart attack.
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I have had one stroke in the past.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot do certain exercises because of health issues.
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I have been diagnosed with primary progressive aphasia.
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I had a stroke caused by bleeding in my brain from a burst blood vessel.
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I have a neurological condition like MS, Parkinson's, or dementia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Aphasia Communication Outcome Measure (ACOM) (Hula et al., 2015)
The Boston Naming Test

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Treatment 1Experimental Treatment3 Interventions
Group II: Treatment 2Active Control3 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Language therapy
2016
N/A
~20
Aerobic Exercise
2020
Completed Early Phase 1
~1340

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Aphasia treatments commonly involve speech and language therapy, which focuses on improving communication abilities through repetitive and structured practice of language tasks. The mechanisms of action include enhancing neuroplasticity, which is the brain's ability to reorganize and form new neural connections. Combining speech therapy with aerobic exercise can further enhance these benefits by increasing blood flow to the brain, promoting the release of neurotrophic factors, and improving overall cognitive function. This combined approach is significant for aphasia patients as it can lead to more substantial and faster improvements in language skills, thereby enhancing their ability to communicate effectively and improving their quality of life.
An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery.Effects of a multimodal exercise intervention on physical and cognitive functions in patients with chronic low back pain (MultiMove): study protocol for a randomized controlled trial.Alterations to dual stream connectivity predicts response to aphasia therapy following stroke.

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,379 Previous Clinical Trials
848,110 Total Patients Enrolled
2 Trials studying Aphasia
25 Patients Enrolled for Aphasia
Elizabeth Galletta, MDPrincipal InvestigatorNYU Langone Medical Center
Elizabeth Galleta, MDPrincipal InvestigatorNYU Langone Medical Center
~1 spots leftby Jul 2025