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Forced Aerobic Exercise for Multiple Sclerosis
N/A
Waitlist Available
Led By Susan M Linder, DPT
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 1 (exercise session 1), week 12 (exercise session 24)
Awards & highlights
Study Summary
This trial will test if two types of aerobic exercise can improve movement for people with multiple sclerosis.
Eligible Conditions
- Multiple Sclerosis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ week 1 (exercise session 1), week 12 (exercise session 24)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 1 (exercise session 1), week 12 (exercise session 24)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Biomechanical Gait Assessment
Exercise variables
Instrumented Timed Up and Go (TUG)
+3 moreSecondary outcome measures
Modified Fatigue Impact Scale
To investigate the role of Klotho in promoting neuroprotection.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Forced Aerobic Exercise (FE)Experimental Treatment1 Intervention
The FE group (N=10) will complete 45 minutes of FE on the custom-engineered cycle designed to augment pedaling rate to greater than 70 revolutions per minute (RPM's). The VE group (N=10) will exercise on an identical semi-recumbent cycle ergometer at their self-selected cadence without assistance.
Group II: Voluntary Aerobic Exercise (VE)Active Control1 Intervention
The VE group (N=10) will exercise on an identical semi-recumbent cycle ergometer for 45 minutes at their self-selected cadence without assistance.
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Who is running the clinical trial?
The Cleveland ClinicLead Sponsor
1,026 Previous Clinical Trials
1,366,056 Total Patients Enrolled
19 Trials studying Multiple Sclerosis
4,128 Patients Enrolled for Multiple Sclerosis
Susan M Linder, DPTPrincipal InvestigatorThe Cleveland Clinic
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have severe muscle tightness or stiffness.You have a serious heart rhythm problem.You were in the hospital for a heart attack, heart failure, or heart surgery within the past 3 months.You have a serious narrowing of the aortic valve in your heart.You have had a blood clot in your lung.You are considered to have a low risk of having a heart problem during physical activity according to the American College of Sports Medicine.You have trouble swallowing and can't drink enough fluids.You are between 18 and 75 years old.You have another reason that makes it unsafe for you to exercise.You have a heart condition called hypertrophic cardiomyopathy.You have been diagnosed with RRMS and your disability scale score is between 1.5 and 6.5.
Research Study Groups:
This trial has the following groups:- Group 1: Forced Aerobic Exercise (FE)
- Group 2: Voluntary Aerobic Exercise (VE)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is it possible to join in this investigation?
"Twenty individuals with multiple sclerosis aged between 18 and 75 are sought for this research. Notably, they must have a confirmed diagnosis of RRMS, as well as an Expanded Disability Status Scale (EDSS) score ranging from 1.5 to 6.5."
Answered by AI
Are individuals over 40 in the accepted age range for this investigation?
"As outlined in the study protocols, individuals aged 18 to 75 are eligible for enrollment."
Answered by AI
Are recruitment efforts underway for this research endeavor?
"According to clinicaltrials.gov, this specific medical trial is not currently accepting new patients and was last revised on September 28th 2022. Nonetheless, there are 555 other trials actively searching for participants at the moment."
Answered by AI
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