Salivary Biomarkers for Concussion Recovery
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests if exercise can help concussed adolescents recover by tracking changes in specific markers in their saliva. The study involves giving them specific exercise routines and measuring these markers to see if they indicate recovery.
Will I have to stop taking my current medications?
The trial excludes participants who are currently taking medications for ADHD, learning disorders, depression, anxiety, or other medications that can affect heart rate. If you are on these medications, you would not be eligible to participate.
Is aerobic exercise generally safe for humans?
High-intensity interval exercise (HIIE) can be safe for people with cardiovascular and metabolic diseases if they are clinically stable and have prior experience with moderate exercise, but it may have a higher risk of adverse responses compared to moderate exercise. Supervision and monitoring are recommended during and after exercise sessions.12345
How does high volume and low volume aerobic exercise treatment differ from other treatments?
High volume and low volume aerobic exercise treatments are unique because they focus on varying the intensity and duration of exercise to improve cardiovascular health and fitness. Unlike traditional continuous exercise, these treatments can be more time-efficient and adaptable to different fitness levels, making them accessible for sedentary individuals.678910
What data supports the effectiveness of the treatment High Volume Aerobic Exercise, Low Volume Aerobic Exercise?
Research shows that aerobic exercise, whether high or low volume, can improve fitness and heart health in patients with heart failure. Higher intensity aerobic exercise has been found to increase peak oxygen uptake, which is a key measure of cardiovascular fitness, more effectively than usual care.1112131415
Who Is on the Research Team?
John Leddy, MD
Principal Investigator
University at Buffalo
Praveen Arany, DDS, PhD
Principal Investigator
University at Buffalo
Mohammad Nadir, MD, PhD
Principal Investigator
University at Buffalo
Barry Willer, PhD
Principal Investigator
University at Buffalo
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline assessments including the Buffalo Concussion Physical Exam and saliva collection
Treatment
Participants receive individualized exercise prescriptions based on the Buffalo Concussion Treadmill Test results
Follow-up
Participants are monitored for recovery and changes in salivary biomarkers
What Are the Treatments Tested in This Trial?
Interventions
- High Volume Aerobic Exercise
- Low Volume Aerobic Exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
State University of New York at Buffalo
Lead Sponsor
National Center for Advancing Translational Sciences (NCATS)
Collaborator