Reviewed by Michael Gill, B. Sc.
Image of University of Ottawa Heart Institute in Ottawa, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Treatment Algorithmfor Mitral Valve Insufficiency

18+
All Sexes
Ischemic mitral regurgitation is a disease where the mitral valve is regurgitant, or leaking, as a result of changes in the muscle of the heart caused by coronary artery disease Ischemic mitral regurgitation, or IMR, is normally treated by repairing or replacing the mitral valve. Currently, we don't have very strong evidence showing which patients might benefit from mitral valve repair and which might benefit from replacement, and surgeons tend to repair or replace valves based on their preference or experience. Some surgeons, including Dr. Vincent Chan, the Principal Investigator, believe that the decision to repair or replace the valve should be based on specific measurements of the mitral valve. This study will randomly assign patients to receive either the current standard of care for ischemic mitral regurgitation, which is valve repair or replacement based on the surgeon's preference, or to have their treatment decided by a set of criteria called an algorithm. This algorithm will assign patients with certain mitral valve measurements to repair, and others to replacement. Patients will be followed for 12 months after surgery, to compare whether patients whose treatment was decided by the algorithm did better than patients whose treatment was decided by surgeon preference.
Waitlist Available
Has No Placebo
University of Ottawa Heart InstituteVincent Chan, MD
25 Anterior Ischemic Optic Neuropathy Clinical Trials Near Me
Top Hospitals for Anterior Ischemic Optic Neuropathy Clinical Trials
Image of Vancouver General Hospital in British Columbia.
Vancouver General Hospital
Vancouver
5Active Trials
0All Time Trials for Anterior Ischemic Optic Neuropathy
2015First Anterior Ischemic Optic Neuropathy Trial
Image of London Health Sciences Centre in Ontario.
London Health Sciences Centre
London
5Active Trials
0All Time Trials for Anterior Ischemic Optic Neuropathy
2009First Anterior Ischemic Optic Neuropathy Trial
Top Cities for Anterior Ischemic Optic Neuropathy Clinical Trials
Anterior Ischemic Optic Neuropathy Clinical Trials by Phase of Trial
Phase < 1 Anterior Ischemic Optic Neuropathy Clinical Trials
2Active Anterior Ischemic Optic Neuropathy Clinical Trials
2Number of Unique Treatments
1Number of Active Locations
Patients who didn't fail AADNormal controls
Anterior Ischemic Optic Neuropathy Clinical Trials by Age Group
< 18 Anterior Ischemic Optic Neuropathy Clinical Trials
7Active Anterior Ischemic Optic Neuropathy Clinical Trials
Sensorimotor InterventionArm 3: High dose caffeineRemote Ischemic Conditioning (RIC)RLICLow Dose Caffeine (5 mg/kg)Sulfur hexafluoride lipid-type A microspheresTopiramate
Top Treatments for Anterior Ischemic Optic Neuropathy Clinical Trials
Treatment Name
Active Anterior Ischemic Optic Neuropathy Clinical Trials
All Time Trials for Anterior Ischemic Optic Neuropathy
First Recorded Anterior Ischemic Optic Neuropathy Trial
Intervention
3
3
2012
1
3
3
2008
Ischemic Conditioning
2
2
2018
30 mg dose of JVS-100
2
2
2012
autoRIC®
2
2
2018

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 24th, 2021

Last Reviewed: November 8th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References1 Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. https://pubmed.ncbi.nlm.nih.gov/115569412 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004 Aug;240(2):205-13. https://pubmed.ncbi.nlm.nih.gov/152735423 Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): Development and Initial Psychometric Evaluation. J Trauma Stress. 2015 Dec;28(6):489-98. doi: 10.1002/jts.22059. Epub 2015 Nov 25. https://pubmed.ncbi.nlm.nih.gov/266062504 Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA; American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Jul;45(7):2160-236. doi: 10.1161/STR.0000000000000024. Epub 2014 May 1. Erratum in: Stroke. 2015 Feb;46(2):e54. https://pubmed.ncbi.nlm.nih.gov/247889675 Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007 Aug 18;370(9587):575-9. https://pubmed.ncbi.nlm.nih.gov/177077526 Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015 Mar 12;372(11):1019-30. doi: 10.1056/NEJMoa1414905. Epub 2015 Feb 11. https://pubmed.ncbi.nlm.nih.gov/256717987 Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004 Oct 6;44(7):1393-9. https://pubmed.ncbi.nlm.nih.gov/154643188 Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, San Román L, Serena J, Abilleira S, Ribó M, Millán M, Urra X, Cardona P, López-Cancio E, Tomasello A, Castaño C, Blasco J, Aja L, Dorado L, Quesada H, Rubiera M, Hernandez-Pérez M, Goyal M, Demchuk AM, von Kummer R, Gallofré M, Dávalos A; REVASCAT Trial Investigators. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015 Jun 11;372(24):2296-306. doi: 10.1056/NEJMoa1503780. Epub 2015 Apr 17. https://pubmed.ncbi.nlm.nih.gov/258825109 Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007 Aug 18;370(9587):575-9. https://pubmed.ncbi.nlm.nih.gov/1770775210 Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Ip JH; Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005 Jan 20;352(3):225-37. Erratum in: N Engl J Med. 2005 May 19;352(20):2146. https://pubmed.ncbi.nlm.nih.gov/15659722