Orthostatic Intolerance Clinical Trials
Here are the 5 most popular medical studies for orthostatic intolerance
Electrolyte Solution
Saline Solution for Orthostatic Intolerance
This trial will test whether people with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI/POTS) have difficulty conserving sodium, compared to healthy control subjects.
Assessing Aldosterone & Sodium Regulation in Postural Orthostatic Tachycardia Syndrome
This trial is important to determine if patients have Postural Tachycardia Syndrome and reduced blood volume, and if a high dietary sodium level can help improve symptoms.
Behavioural Intervention
Inspiratory Threshold Device for Postural Orthostatic Tachycardia Syndrome (POTS)
This trial will test whether a breathing device can help people with postural tachycardia syndrome stay upright and reduce heart rate increases when standing.
Popular filter options for orthostatic intolerance trials
Postural Orthostatic Tachycardia Syndrome Clinical Trials
View 11 Postural Orthostatic Tachycardia Syndrome medical studies.
Behavioral Intervention
Counterpressure Maneuvers for Fainting
This trial studies how counterpressure maneuvers, like swaying and muscle tensing, affect children's blood pressure and cardiovascular control when they faint. Measures like blood pressure, cerebral blood flow, and stroke volume will be compared across different groups.
N/A
Counterpressure Maneuvers for Paediatric Syncope
This trial will assess whether counterpressure maneuvers (CPM) can prevent syncope in children. In stage I, participants will fill out a survey about their syncopal episode and any prodromal symptoms. In stage II, some participants will be trained in CPM and all will be followed for one year. Surveys and medical records will be used to assess syncopal and presyncopal recurrence and changes in medical diagnosis.
POTS Clinical Trials
View 11 POTS medical studies.
Behavioral Intervention
Counterpressure Maneuvers for Fainting
This trial studies how counterpressure maneuvers, like swaying and muscle tensing, affect children's blood pressure and cardiovascular control when they faint. Measures like blood pressure, cerebral blood flow, and stroke volume will be compared across different groups.
N/A
Counterpressure Maneuvers for Paediatric Syncope
This trial will assess whether counterpressure maneuvers (CPM) can prevent syncope in children. In stage I, participants will fill out a survey about their syncopal episode and any prodromal symptoms. In stage II, some participants will be trained in CPM and all will be followed for one year. Surveys and medical records will be used to assess syncopal and presyncopal recurrence and changes in medical diagnosis.
Orthostatic Intolerance Clinical Trials With No Placebo
View 15 orthostatic intolerance medical studies that do not have a placebo group.
N/A
Counterpressure Maneuvers for Paediatric Syncope
This trial will assess whether counterpressure maneuvers (CPM) can prevent syncope in children. In stage I, participants will fill out a survey about their syncopal episode and any prodromal symptoms. In stage II, some participants will be trained in CPM and all will be followed for one year. Surveys and medical records will be used to assess syncopal and presyncopal recurrence and changes in medical diagnosis.
Behavioural Intervention
Muscle Pre-activation for Orthostatic Hypotension
This trial is looking at a possible treatment for Initial Orthostatic Hypotension, which is a drop in blood pressure when standing up. The study will look at four different ways of standing up, with different stress tests, to see which is the most effective in reducing symptoms and preventing syncope (fainting).
Alpha-1 Agonist
Midodrine for Parkinson's Disease
This trial will test whether the drug midodrine can reduce feelings of lightheadedness in patients with or without orthostatic hypotension (low blood pressure when standing up). It will also look at the drug's effect on blood pressure and heart rate during a physical test, and how this relates to symptom improvement.
Frequently Asked Questions
Introduction to orthostatic intolerance
What are the top hospitals conducting orthostatic intolerance research?
When it comes to advancing our understanding and treatment of orthostatic intolerance, several hospitals are making significant strides in research. One such institution is Vanderbilt University in Nashville, which has three active clinical trials dedicated to orthostatic intolerance and a total of seven trials since their pioneering investigation began in 1996. Another hub of innovation is the University of Calgary in Canada's bustling city of Calgary, where two ongoing trials are underway alongside their notable achievement of two completed studies since venturing into this field just recently in 2019.
Additionally, Vanderbilt University Medical Center continues the momentum with two ongoing orthostatic intolerance trials that add to their impressive track record comprising three previous investigations since initiating their first trial back in 2007. On the west coast, Simon Fraser University located in Burnaby enters the scene with one active clinical trial for orthostatic intolerance and an ambitious plan for future advancements as they carry out their inaugural study slated for 2023. Lastly, BC Children's Hospital situated amidst Vancouver's thriving medical community also plays a crucial role by actively engaging in one current clinical trial while having achieved another successful endeavor documented during their maiden exploration into orthostatic intolerance treatments recorded last year in 2022.
These esteemed institutions demonstrate unwavering dedication towards addressing the challenges faced by individuals living with orthostatic intolerance. Through continuous scientific inquiry and innovative approaches within these specialized centers across North America, hope shines brighter than ever before for improving the lives of those affected by this condition on a global scale
Which are the best cities for orthostatic intolerance clinical trials?
When it comes to orthostatic intolerance clinical trials, several cities offer opportunities for research and development. Nashville, Tennessee leads the way with 7 active trials focusing on autonomic function tests, saline interventions, and healthy control subjects. Calgary, Alberta follows with 2 ongoing studies investigating all participants and functional electrical stimulation. Burnaby, British Columbia and Vancouver, British Columbia have 1 active trial each exploring counterpressure maneuvers. Lastly, Oklahomag all participants and functional electrical stimulation. Burnaby, British Columbia and Vancouver, British Columbia have 1 active trial each exploring counterpressure maneuvers. Lastly, Oklahoma City, Oklahoma conducts a trial centered around autonomic function tests. These cities provide individuals with orthostatic intolerance an avenue to participate in clinical trials that contribute to advancements in understanding and treating this condition.
Which are the top treatments for orthostatic intolerance being explored in clinical trials?
Orthostatic intolerance, a condition characterized by difficulty in maintaining blood pressure and heart rate when standing up, is currently being investigated for potential treatments through clinical trials. Prominent among these are counterpressure maneuvers, which are being explored in two active trials dedicated to orthostatic intolerance and were first listed in 2022. Another promising treatment option is functional electrical stimulation, under investigation in one ongoing trial since its introduction in 2019. Autonomic function tests also show promise with one active trial focusing on orthostatic intolerance since 2016. Additionally, midodrine has gained attention as a potential treatment option with one ongoing trial and three all-time trials for orthostatic intolerance dating back to 1997. These research efforts aim to improve the lives of individuals dealing with this challenging condition by advancing our understanding of effective therapeutic interventions.
What are the most recent clinical trials for orthostatic intolerance?
Recent clinical trials have been exploring various treatment options for orthostatic intolerance, a condition characterized by the inability to maintain blood pressure and heart rate when standing upright. One promising avenue is the use of stellate ganglion blocks, which involves injecting an anesthetic near the neck to block certain nerve signals that contribute to orthostatic intolerance symptoms. Additionally, normal saline has been investigated as a potential intervention, as it helps replenish fluids and improve blood volume regulation in individuals with this condition. Another study focused on modafinil, a medication known for its wakefulness-promoting properties that may help alleviate symptoms in patients suffering from orthostatic intolerance. These ongoing trials offer hope for improved management and quality of life for those affected by this challenging disorder.
What orthostatic intolerance clinical trials were recently completed?
Vanderbilt University Medical Center recently completed a clinical trial in July 2018 investigating the efficacy of Atomoxetine for orthostatic intolerance. This important study contributes to our understanding of potential treatments for this condition, bringing hope to those suffering from its debilitating symptoms.