Treatment for Postural Orthostatic Tachycardia Syndrome

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Postural Orthostatic Tachycardia Syndrome+1 More
Eligibility
18 - 60
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether CO2 can help people with POTS by lowering heart rate and reducing symptoms when upright/standing.

Eligible Conditions
  • Postural Orthostatic Tachycardia Syndrome
  • Orthostatic Intolerance

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: difference between HR from supine to peak HR during tilt test for each intervention (mean value HR between the 8th and 9th minute of supine; peak parameters, during HUTT, mean value during the first min and between the 3rd and 8th min)

VOSS will be accessed at the 8th minute of each HUTT, comparing the intensity of symptoms in each intervention
VOSS symptom score
difference between CBFv from supine to peak during tilt test for each intervention (mean value CBFv between the 8th and 9th min of supine; peak parameters, during HUTT, mean value CBFv during the first min and between the 3rd and 8th min)
Cerebral blood flow velocity (CBFv) variation
difference between HR from supine to peak HR during tilt test for each intervention (mean value HR between the 8th and 9th minute of supine; peak parameters, during HUTT, mean value during the first min and between the 3rd and 8th min)
Heart Rate (HR) variation

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

26 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: difference between hr from supine to peak hr during tilt test for each intervention (mean value hr between the 8th and 9th minute of supine; peak parameters, during hutt, mean value during the first min and between the 3rd and 8th min)

Who is running the clinical trial?

University of CalgaryLead Sponsor
706 Previous Clinical Trials
493,675 Total Patients Enrolled
6 Trials studying Postural Orthostatic Tachycardia Syndrome
487 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
Satish R Raj, MD, MSCIPrincipal InvestigatorUniversity of Calgary, Cardiac Science
4 Previous Clinical Trials
261 Total Patients Enrolled
2 Trials studying Postural Orthostatic Tachycardia Syndrome
157 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

Eligibility Criteria

Age 18 - 60 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are able to travel to the University of Calgary.
You are not a smoker.
References