Motion Reset for Cybersickness in Virtual Reality

Recruiting at 1 trial location

Overseen By Susan J Persky, Ph.D.

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: National Human Genome Research Institute (NHGRI)

Must not be taking: Nausea inhibitors

Disqualifiers: Motion sickness, Seizure disorders, Pregnancy, others

Compensation: Varies

Number of Visits: 4

150 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests new software called Motion Reset to determine if it can reduce cybersickness symptoms such as eye strain, nausea, dizziness, or headaches during virtual reality (VR) use. Researchers will divide participants into three groups to experience different VR settings and identify which setting provides the most relief. Healthy adults who have experienced some level of motion sickness and do not have conditions that increase nausea susceptibility are ideal candidates for this study. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance VR experiences for many.

Will I have to stop taking my current medications?

If you are currently using medications or supplements that prevent nausea, like Zofran or Phenergan, you cannot participate in this trial.

What prior data suggests that the Motion Reset software is safe for reducing cybersickness in VR users?

Research has shown that specific safety information for the Motion Reset software is not available. However, virtual reality (VR) can sometimes cause mild and temporary symptoms such as nausea or dizziness. In one study, about 45% of VR users experienced these symptoms during use, and 25% continued to feel them an hour later. Although this study does not specifically cover Motion Reset, it provides insight into what VR users might generally experience. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Motion Reset protocol for cybersickness in virtual reality because it aims to tackle the problem directly by adjusting the user's sensory input in real-time. Unlike other methods that rely on medications or gradual exposure to reduce symptoms, Motion Reset is designed to recalibrate the user’s experience instantly, potentially offering immediate relief. This innovative approach could revolutionize how we manage cybersickness, making virtual reality more accessible and enjoyable for everyone.

What evidence suggests that Motion Reset is effective for reducing cybersickness?

Research has shown that software like Motion Reset, which participants in this trial may experience, can help reduce cybersickness, a condition similar to motion sickness. Adding a virtual nose to VR displays has been shown to reduce motion sickness symptoms. Another method, called teleportation, can also help but might make it harder to orient oneself in the virtual world. Some studies indicate that VR can cause discomfort, such as nausea and dizziness, but innovations like Motion Reset aim to address these issues. While specific data on Motion Reset is still being gathered, these strategies offer promising ways to reduce cybersickness during VR use. ^{1 6 7 8 9}

Who Is on the Research Team?

Susan J Persky, Ph.D.

Principal Investigator

National Human Genome Research Institute (NHGRI)

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 18 to 60 who are interested in participating in a study involving virtual reality (VR). The goal is to see if new software can help prevent the discomfort some people feel after using VR, known as cybersickness.

Inclusion Criteria

Provision of signed and dated informed consent form

Ability to read, speak, and write in English

My hearing is normal or corrected to normal.

Exclusion Criteria

Reporting motion sickness propensity of 0 or 10 on a 0-10 scale where 0 =never experience motion sickness and 10 = experience motion sickness very frequently (self-assessed by participants)

I am currently taking medication to prevent nausea.

I have a history of conditions like seizures or dizziness.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 hour

1 visit (in-person)

Intervention

Participants are assigned to one of three groups to experience VR activities designed to prevent or not prevent cybersickness, or no VR experience.

1 hour

1 visit (in-person)

VR Game Session

All participants play a commercial VR game and are monitored for cybersickness symptoms.

20 minutes

1 visit (in-person)

Follow-up

Participants complete questionnaires about their VR experience and symptoms.

1 hour

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Motion Reset

Trial Overview The trial tests Motion Reset software designed to reduce symptoms of cybersickness against a placebo during VR use. Participants will be divided into groups; one with prevention-focused VR experience, another without it, and a control group with no VR.

How Is the Trial Designed?

Group I: Intervention: Motion Reset Experimental Treatment 1 Intervention

Participate in virtual reality activities

Group II: No intervention Active Control 1 Intervention

Group III: Placebo experience Placebo Group 1 Intervention

Participate in virtual reality activities

Who Is Running the Clinical Trial?

National Human Genome Research Institute (NHGRI)

Lead Sponsor

Trials

273

Recruited

299,000+

Citations

1. withpower.com withpower.com/trial/motion-reset-for-cybersickness-in-virtual-reality-5b1f4

Motion Reset for Cybersickness in Virtual Reality New software called Motion Reset is being designed to reduce symptoms of cybersickness during VR use.

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11522211/

Preregistered test of whether a virtual nose reduces ... Recent findings suggest that adding a visual depiction of a nose to virtual reality displays (virtual nose) can reduce motion sickness.

3. sciencedirect.com sciencedirect.com/science/article/pii/S1471595325001325

Cybersickness and discomfort from head-mounted displays ... Worse cybersickness outcomes (e.g. nausea, headache, dizziness, disorientation) or discomfort have been documented during or after VR immersion than common ...

4. researchgate.net researchgate.net/publication/383311510_Virtual_Reality_Sickness_and_its_Impact_on_the_Effectiveness_of_Virtual_Reality_Training

(PDF) Virtual Reality Sickness and its Impact on the ... Results confirm that teleportation (HTR) minimizes cybersickness but negatively impacts spatial orientation. CBS support more efficient ...

5. dl.acm.org dl.acm.org/doi/10.1145/3670008

“Are you feeling sick?” – A systematic literature review of ... Research using a helicopter simulator found that participants reported higher CS scores during stormy conditions compared to clear weather [2].

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10684476/

Frequency-Dependent Reduction of Cybersickness in ... tACS significantly reduced CS nausea in 37 healthy subjects during a VR rollercoaster experience. The effect was frequency-dependent and placebo ...

7. sciencedirect.com sciencedirect.com/science/article/pii/S2173580823000147

Cybersickness. A systematic literature review of adverse ... They found that 45% of the subjects suffered side effects, and 25% felt these side effects one hour after finishing the test. ... In 1995, Kay Stanney used the ...

8. ieeexplore.ieee.org ieeexplore.ieee.org/document/10242330/

Assessment of Virtual Reality Motion Sickness Severity ... This article introduces regression models based on recurrent neural network to predict the user's VRMS severity from their EEG data.

9. tandfonline.com tandfonline.com/doi/full/10.1080/10447318.2020.1778351

Virtual Reality Sickness: A Review of Causes and ... Considering the speed of the VR scene, previous studies have shown that users report more severe VR sickness as the movement becomes faster ( ...