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Azithromycin Impact on Exercise Performance

Q: To whom is this therapeutic research accessible?

In order to qualify, potential participants must have a healthy gastrointestinal <a href="https://www.withpower.com/clinical-trials/microbiome">microbiome</a> and be within the 18-40 age range. The total number of accepted applicants is 40.

Q: Is eligibility for this research project restricted to a certain age bracket?

Patients aged 18-40 are eligible for this clinical trial. For those younger or older, there 14 studies available for minors and 65 studies accessible to seniors.

Q: Are volunteers being welcomed to partake in this research endeavor?

As per information on clinicaltrials.gov, applications for this medical trial are not being accepted at the moment; though it was initially posted in September 1st 2023 and last edited on July 17th 2023. Fortunately, 104 other studies require participants now.

Phase < 1

Recruiting

Led By Sara C Campbell, PhD

Research Sponsored by Rutgers, The State University of New Jersey

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up one week

Awards & highlights

Study Summary

This trial will study how a 5-day antibiotic treatment affects exercise performance in healthy adults.

Who is the study for?

This trial is for healthy adults aged 18-40 who exercise regularly (at least 150 minutes of moderate-to-vigorous activity per week) and can run on a treadmill for an hour. Women must use hormonal contraception. People with recent antibiotic or probiotic use, drug hypersensitivity, certain health conditions, or pregnancy are excluded.Check my eligibility

What is being tested?

The study tests the effect of a short-term course of Azithromycin, an antibiotic, on exercise performance in young adults. Participants will be randomly assigned to receive either Azithromycin or a placebo for five days and their treadmill performance will be compared before and after treatment.See study design

What are the potential side effects?

Azithromycin may cause side effects like digestive issues (nausea, diarrhea), potential liver problems (jaundice), allergic reactions in those sensitive to similar drugs, and could affect gut bacteria balance which is being studied in relation to exercise.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one week

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one week

This trial's timeline: 3 weeks for screening, Varies for treatment, and one week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in gut microbiota

Maximal Oxygen Uptake

Metabolomics

+1 more

Secondary outcome measures

Serum blood measurments

Other outcome measures

Anthropometrics

Body composition

Diet assessment

Side effects data

From 2018 Phase 4 trial • 190238 Patients • NCT02047981

Death

100%

80%

60%

40%

20%

Study treatment Arm

Biannual Mass Oral Placebo

Biannual Mass Oral Azithromycin

Trial Design

1Treatment groups

Experimental Treatment

Group I: Antibiotics and exerciseExperimental Treatment1 Intervention

Participants will be tested before and after 5 days of azithromycin, per manufacturer's instructions, to determine if that impacts exercise performance and the gut microbiome and gut/serum metabolome.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Azithromycin

2018

Completed Phase 4

~274950

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor

429 Previous Clinical Trials

64,192 Total Patients Enrolled

Colorado State UniversityOTHER

125 Previous Clinical Trials

38,319 Total Patients Enrolled

Sara C Campbell, PhDPrincipal InvestigatorRutgers, The State University of New Jersry

Media Library

Antibiotics and exercise Clinical Trial Eligibility Overview. Trial Name: NCT05961189 — Phase < 1

Gastrointestinal Microbiome Research Study Groups: Antibiotics and exercise

Gastrointestinal Microbiome Clinical Trial 2023: Antibiotics and exercise Highlights & Side Effects. Trial Name: NCT05961189 — Phase < 1

Antibiotics and exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05961189 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To whom is this therapeutic research accessible?

"In order to qualify, potential participants must have a healthy gastrointestinal microbiome and be within the 18-40 age range. The total number of accepted applicants is 40."

Answered by AI

Is eligibility for this research project restricted to a certain age bracket?

"Patients aged 18-40 are eligible for this clinical trial. For those younger or older, there 14 studies available for minors and 65 studies accessible to seniors."

Answered by AI

Are volunteers being welcomed to partake in this research endeavor?

"As per information on clinicaltrials.gov, applications for this medical trial are not being accepted at the moment; though it was initially posted in September 1st 2023 and last edited on July 17th 2023. Fortunately, 104 other studies require participants now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Influence of Short-Term Antibiotic Therapy on Exercise

Sara C. Campbell, PhD, FACSM 2023. "Influence of Short-Term Antibiotic Therapy on Exercise". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05961189.