Blueberry Compounds for Healthy Eating
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how the body absorbs anthocyanins, compounds found in blueberries, when consumed in different forms. Researchers aim to determine whether blueberry extract or whole blueberry powder affects the absorption and utilization of these compounds. The goal is to understand how anthocyanins might enhance health and combat disease. Healthy, non-smoking adults who can adhere to a berry-free diet during the study may be suitable candidates. As an unphased trial, this study allows participants to contribute to foundational research that could lead to new health insights.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, it does require participants to follow a berry-restricted diet and document any accidental consumption of restricted foods.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that blueberries are generally safe for most people. In studies with rats, natural chemicals from blueberries, called polyphenols, caused no harm even in large amounts. Some individuals might experience minor issues like constipation, diarrhea, nausea, or vomiting when consuming products made with freeze-dried blueberries.
No strong evidence indicates harmful effects from blueberry powder, but inhaling it might irritate the nose, throat, and lungs. Overall, blueberries are considered safe for most people, but it's always wise to observe how your body responds.12345Why are researchers excited about this trial?
Researchers are excited about these treatments because they focus on natural compounds found in blueberries, which are being explored for promoting healthy eating habits. Unlike traditional supplements or medications, these options use blueberry extract and blueberry powder, leveraging their potential nutritional benefits directly from fruit sources. This approach may offer a unique, food-based strategy to improve dietary health, potentially providing a tasty and easily integrated option for enhancing nutrition.
What evidence suggests that this trial's treatments could be effective?
Research shows that blueberries contain compounds, such as anthocyanins, which offer several health benefits. Studies have found that consuming blueberries can protect parts of the brain, improve memory, and reduce inflammation. They also help maintain gut health by strengthening the gut lining and reducing its permeability. Additionally, blueberries can aid in weight loss and reduce body fat. In this trial, participants will receive either a blueberry extract or blueberry powder confection to evaluate their effects. Blueberry extract is rich in antioxidants and may boost mood, enhance memory, and lower blood sugar levels. These findings suggest that blueberry compounds could benefit overall health and help prevent diseases.46789
Who Is on the Research Team?
Yael Vodovotz
Principal Investigator
Ohio State University Comprehensive Cancer Center
Are You a Good Fit for This Trial?
This trial is for healthy, non-smoking adults with a BMI of 18-35 who are not pregnant, planning to conceive, or lactating. Participants must not have any metabolic, digestive or immunologic disorders and no allergies to blueberries, wheat, or soy. They should agree to avoid berries during the study and report any accidental intake.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Washout
Participants undergo a washout period to clear previous dietary influences
Treatment
Participants consume blueberry extract or powder confections and undergo metabolomic assessments
Follow-up
Participants are monitored for bioavailability and metabolite profile after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Blueberry Powder Food Product
Trial Overview
The study is testing how well compounds called anthocyanins from blueberries are absorbed when consumed as part of two different confections: one made from blueberry extract and another from whole blueberry powder. The goal is to understand their impact on health and disease prevention.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants undergo a washout on days -7 to -1 and then consume blueberry powder confection on day 0. Participants undergo a second washout on days 1-7 and then consume blueberry extract confection on day 8.
Participants undergo a washout on days -7 to -1 and then consume blueberry extract confection on day 0. Participants undergo a second washout on days 1-7 and then consume blueberry powder confection on day 8.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University Comprehensive Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Published Research Related to This Trial
Citations
Recent Research on the Health Benefits of Blueberries and ...
Blueberry supplementation protected vulnerable brain regions, reduced deficits in spatial memory, and mitigated markers of inflammation and oxidative stress in ...
Scientific Evidence for the Beneficial Effects of Dietary ...
Our data analysis indicates that blueberry supplementation improves gut health by improving intestinal morphology, reducing gut permeability, suppressing ...
Investigation of the impact of blueberries on metabolic ...
Blueberries consumed on a daily basis have been shown to significantly reduce weight loss and body fat levels in humans. •. Blueberry phenolics and antioxidants ...
Blueberry Extract Benefits and Precautions
Blueberry extract is rich in antioxidants like quercetin and anthocyanins and may have benefits such as improving mood and memory, and lowering blood sugar.
Effects of Blueberry Consumption on Cardiovascular ...
Plasma NO2- levels were improved by 68.66% and 4.34% separately following whole blueberry and blueberry powder supplementations compared to the baseline, ...
A 90 DAY ORAL TOXICITY STUDY OF BLUEBERRY ...
No adverse effects induced by purified blueberry polyphenols in rats. Proposed NOAEL of ≥ 1000 mg/kg bw/d for blueberry polyphenols in OVX rats.
Blueberry - Uses, Side Effects, and More
Drinks made with freeze-dried blueberries might cause constipation, diarrhea, nausea, or vomiting in some people. There isn't enough reliable information to ...
SAFETY DATA SHEET
may cause irritation of the nose, throat and lungs. No known significant effects or critical hazards. : Ingestion. Skin contact. : No known significant effects ...
Blueberry: Health Benefits, Side Effects, Uses, Dose & ...
Learn more about Blueberry health benefits, uses, side effects, effectiveness, safety, precautions, and warnings.
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