← Back to Search

Drug Effects for Postural Orthostatic Tachycardia Syndrome

N/A

Recruiting

Led By David Robertson, MD

Research Sponsored by Satish R. Raj

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Orthostatic intolerance

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 hours

Awards & highlights

Study Summary

This trial is to study the effects of different drugs on people with a syndrome that causes symptoms like a fast heart rate, fatigue, and dizziness when standing up.

Who is the study for?

This trial is for young adults, especially females, who experience rapid heartbeat, fatigue, lightheadedness, and other symptoms when standing up (Orthostatic Intolerance). Participants must be able to give informed consent.Check my eligibility

What is being tested?

The study aims to understand the causes of Orthostatic Intolerance by using cardiovascular physiological tests like DAXOR for blood volume measurement, QSweat for sweat production analysis, and checking intrinsic heart rate.See study design

What are the potential side effects?

Since this trial involves diagnostic procedures rather than medications or invasive treatments, side effects are minimal but may include discomfort from testing equipment or minor reactions at sensor attachment sites.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I feel dizzy or faint when standing up.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Physiological abnormalities in orthostatic intolerance

Secondary outcome measures

blood volume

intrinsic heart rate

norepinephrine spillover

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: PatientsExperimental Treatment3 Interventions

Patients with orthostatic intolerance

Group II: Healthy Control SubjectsExperimental Treatment3 Interventions

Healthy subjects to determine "normal" response

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

QSweat

1996

Completed Phase 1

~10

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Satish R. RajLead Sponsor

6 Previous Clinical Trials

430 Total Patients Enrolled

2 Trials studying Postural Orthostatic Tachycardia Syndrome

200 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

National Institutes of Health (NIH)NIH

2,701 Previous Clinical Trials

7,506,776 Total Patients Enrolled

7 Trials studying Postural Orthostatic Tachycardia Syndrome

334 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

David Robertson, MDPrincipal InvestigatorVanderbilt University

3 Previous Clinical Trials

138 Total Patients Enrolled

Media Library

Healthy Control Subjects Clinical Trial Eligibility Overview. Trial Name: NCT00608725 — N/A

Postural Orthostatic Tachycardia Syndrome Research Study Groups: Healthy Control Subjects, Patients

Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Healthy Control Subjects Highlights & Side Effects. Trial Name: NCT00608725 — N/A

Healthy Control Subjects 2023 Treatment Timeline for Medical Study. Trial Name: NCT00608725 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is eligibility limited to individuals younger than 45 for this research endeavor?

"According to the requirements of this research, candidates must be no younger than 18 and not older than 80."

Answered by AI

How many individuals are being observed for this research project?

"Affirmative. Clinicaltrials.gov data reveals that this trial, which was first posted on December 1st 1996, is actively searching for participants. Approximately 100 patients are required at one medical centre to complete the research project."

Answered by AI

May I partake in this research endeavor?

"This trial aims to enroll 100 individuals with tachycardia aged between 18-80. In addition, they must also suffer from orthostatic intolerance in order to be considered for the study."

Answered by AI

What ailments are commonly addressed with this therapy?

"This treatment is clinically proven to be effective in treating cardiovascular mortality, angina pectoris, and myocardial infarction."

Answered by AI

Are there any open slots available for participation in this trial?

"That is accurate. According to the resources on clinicaltrials.gov, this research project began recruitment on December 1st 1996 and has been updated as recently as September 12th 2022. A total of 100 patients are wanted from one site for participation in the trial."

Answered by AI