Remote Ischemic Conditioning for Multiple Sclerosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether remote ischemic conditioning (RIC) can help individuals with primary progressive multiple sclerosis (PPMS) maintain their walking ability. RIC involves temporarily restricting blood flow to a limb and has shown promise in protecting brain cells in stroke patients. Researchers aim to determine if RIC can repair nerve damage in those with PPMS. This trial suits individuals diagnosed with PPMS who find walking increasingly difficult. As an unphased trial, it offers participants a unique opportunity to contribute to pioneering research that could lead to new treatments for PPMS.
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as immune-modulators, blood thinners, Fampridine, 4-aminopyridine, Baclofen, and Tizanidine. If you are on these medications, you may need to stop them to participate in the study.
What prior data suggests that this technique is safe for people with multiple sclerosis?
Research shows that Remote Ischemic Conditioning (RIC) is safe and generally well-tolerated. Studies with stroke patients indicate that RIC can protect the brain without causing harm. Additionally, research suggests that RIC can be used daily for extended periods without major issues. For other brain-related conditions, RIC has proven safe, with no significant negative effects reported. Overall, RIC appears to be a promising, gentle, non-drug therapy for improving health in various conditions.12345
Why are researchers excited about this trial?
Most treatments for multiple sclerosis (MS) involve medications that modify the immune system, such as interferons or monoclonal antibodies. However, remote ischemic conditioning (RIC) is unique because it doesn't rely on drugs. Instead, it uses a physical technique to temporarily restrict blood flow to an area, which might help protect the nervous system from damage. Researchers are excited about RIC for MS because it offers a non-invasive and potentially safer alternative that could complement existing therapies, providing new hope for patients with fewer side effects.
What evidence suggests that remote ischemic conditioning is effective for multiple sclerosis?
Research has shown that Remote Ischemic Conditioning (RIC), the treatment under study in this trial, could help treat neurological conditions. In stroke patients, RIC aided recovery and reduced brain damage, suggesting it might protect the brain. For people with multiple sclerosis (MS), studies indicate that RIC is safe and helps improve heart rate during walking. Animal studies support these findings, showing protective effects in nerve injury models. Although RIC hasn't been tested in MS for repairing nerve coverings, its safety and past success make it a promising option for further research in progressive MS.12467
Are You a Good Fit for This Trial?
This trial is for individuals with primary progressive multiple sclerosis (PPMS). Specific eligibility criteria are not provided, but typically participants must meet certain health conditions and cannot have factors that would exclude them from safely participating in the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Remote Ischemic Conditioning (RIC) with 4 cycles daily to test its effect on preventing disability progression in PPMS
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments like the Timed 25-foot walk and MRI measures
What Are the Treatments Tested in This Trial?
Interventions
- Remote Ischemic Conditioning
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor