Targeted Therapy Screening for Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes non-match sub-studies which will include all screened patients not eligible for any of the biomarker-driven sub-studies.
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. However, it mentions that patients can be pre-screened while still on their current treatment for Stage IV or recurrent disease.
Is targeted therapy for lung cancer generally safe for humans?
Targeted therapies for lung cancer, like EGFR and ALK inhibitors, have been associated with various side effects, including skin, stomach, lung, and heart issues. While many side effects are manageable, some can be serious, such as lung problems that might require stopping the treatment. It's important for doctors to monitor these side effects closely.12345
How is the Targeted Therapy Screening Platform for lung cancer different from other treatments?
The Targeted Therapy Screening Platform for lung cancer is unique because it focuses on identifying specific genetic mutations in the cancer cells, allowing for the use of targeted drugs that are more effective and have fewer side effects compared to traditional chemotherapy. This approach uses advanced molecular biology techniques to match patients with the most suitable targeted therapies based on their tumor's genetic profile.678910
What data supports the effectiveness of the treatment Screening Platform for lung cancer?
Who Is on the Research Team?
Hossein Borghaei
Principal Investigator
SWOG Cancer Research Network
Are You a Good Fit for This Trial?
This trial is for adults with Stage IV or recurrent non-small cell lung cancer who've progressed after treatment. They must have a good performance status, adequate tumor tissue for testing, and consent to genomic screening. It's not open to those outside the US or with certain genetic mutations unless they've exhausted standard therapies.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Biomarker Analysis
Patient specimens are tested to determine eligibility for biomarker-driven and non-matched sub-studies
Sub-study Assignment
Participants are assigned to a sub-study based on biomarker results
Follow-up
Participants are monitored for safety and effectiveness after sub-study assignment
What Are the Treatments Tested in This Trial?
Interventions
- Screening Platform
Find a Clinic Near You
Who Is Running the Clinical Trial?
Southwest Oncology Group
Lead Sponsor
SWOG Cancer Research Network
Lead Sponsor
National Cancer Institute (NCI)
Collaborator