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Chemotherapy + Durvalumab for Lung Cancer
Study Summary
This trial is testing a new combination of drugs to treat NSCLC. The goal is to increase the N2 nodal clearance (N2NC) to 50% or greater.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am healthy enough for major lung surgery.My organ and bone marrow functions are within normal ranges.I agree to use birth control during and for 12 weeks after the study.My N2 lymph nodes are separate from surrounding tissues and smaller than 3 cm.I have or had an autoimmune or inflammatory disorder.Your heart's electrical activity takes too long to reset itself, and this can be dangerous.I am using two birth control methods or am not having sex to join this study.I am fully active or can carry out light work.I have seen a lung surgeon within the last month.Your disease can be measured using specific guidelines for tumor evaluation.I have had a biopsy of the lymph nodes in my chest before surgery.I have moderate to severe numbness, tingling, or pain in my hands or feet.I had cancer before, but it's been in complete remission for over 2 years, and I don't need treatment now.I have never had radiation therapy to my chest.I have had a solid organ transplant.I have received treatment for non-small cell lung cancer before.You are expected to live for at least 12 more weeks.I do not have any serious ongoing illnesses that could affect my participation in the study.I do not have an active autoimmune disease or a history that required systemic steroids, except for vitiligo or resolved childhood asthma.My cancer is not a mix of small cell and non-small cell lung cancer.My cancer has spread to one or more lymph nodes.I am 18 years old or older.I have received an organ transplant from another person.I have had radiation therapy to the chest area before.I can make my own medical decisions or have someone who can.My cancer was confirmed to be in the lymph nodes within the last month.My lung cancer is at a stage where surgery could remove it completely.I haven't taken high-dose steroids or other immune-weakening drugs in the last 2 weeks.
- Group 1: Treatment
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the FDA sanctioned Radiotherapy as a viable medical treatment?
"As a Phase 2 trial, there is some data suggesting safety but none to back up its efficacy. Therefore we have assigned Radiotherapy a score of 2 on our 1-3 scale."
Are there currently open enrollments for this research endeavor?
"According to clinicaltrials.gov, this experiment is still enrolling participants since it was originally published on March 10th 2021 and last modified on December 7h 2021."
What types of illnesses have seen successful treatment through radiotherapy?
"Radiotherapy is a common approach to treating unresectable stage iii non-small cell lung cancer. Additionally, this technique has been used in the treatment of metastatic urothelial carcinoma and advanced directives."
What other investigations have been conducted involving Radiotherapy?
"Radiotherapy was initially researched in 2010 at City of Hope and has since been subject to 343 trials. Currently, 333 active studies are taking place around the world; notably, a large concentration is based out of Houston, Texas."
How many facilities are presently administering this clinical investigation?
"This trial has 18 sites across the United States, including in Houston, Durham and Oklahoma City. As such, it is paramount for potential participants to pick a medical centre nearby to reduce any necessary travel expenses."
What is the aggregate number of people participating in this investigation?
"Indeed. According to the clinicaltrials.gov portal, this medical trial is currently open for recruitment and was initially posted on March 10th 2021 with a recent update of December 7th 2021. The study seeks 55 participants from 18 different sites."
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