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Intervention Group for Cardiac Arrest

Phase 1
Waitlist Available
Led By Graham Nichol, MD, MPH
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 48 hours of index arrest
Awards & highlights

Study Summary

This trial is testing whether a technique called remote ischemic conditioning (RIC) can help improve outcomes for people who have had a cardiac arrest. RIC involves applying a device to a limb to intermittently restrict blood flow and induce non-lethal ischemia.

Eligible Conditions
  • Cardiac Arrest

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 24 hours of index arrest
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 24 hours of index arrest for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Attrition
Secondary outcome measures
Accrual
Cardiac Function
Cardiogenic Shock
+10 more
Other outcome measures
Device Failure
Expected Adverse Event Related to Cardiac Arrest
Expected Adverse Event Related to Device- Pain
+3 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Intervention GroupActive Control1 Intervention
A standard non-invasive blood pressure cuff (e.g., American Diagnostics Corporation, Hauppauge, NY but any one can be used off the shelf) and disposable plastic clamp (e.g.,Medline Industries Incorporated, Mundelein, IL) can be used to apply RIC in patients resuscitated from OHCA via three cycles of 5-mins. inflation to 200 mmHg followed by 5-mins. deflation of a blood pressure cuff on an upper extremity. The cuff occludes the artery; the clamp maintains pressure in the air bladder of the cuff during the inflation periods.
Group II: Control GroupPlacebo Group1 Intervention
The control group will have a sham package opened at the bedside as soon as feasible after ED arrival. This will be identical in size, weight and appearance as that in the intervention group, but will contain a sham device. Upon identification that the patient has been randomized to the control group, the care team will proceed with all other resuscitative measures as in the the intervention group.

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,740 Previous Clinical Trials
1,847,908 Total Patients Enrolled
8 Trials studying Cardiac Arrest
5,452 Patients Enrolled for Cardiac Arrest
Kettering FoundationUNKNOWN
ZOLL FoundationUNKNOWN
1 Previous Clinical Trials
28 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot
Graham Nichol 2020. "Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04265807.
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