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dose 1 for Cognitive Disorders

N/A
Recruiting
Research Sponsored by Augusta University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 weeks
Awards & highlights

Study Summary

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Eligible Conditions
  • Cognitive Disorders
  • White matter hyperintensities

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
RBC deformability index
Secondary outcome measures
inflammatory and anti-inflammatory Interleukins
tolerability

Trial Design

5Treatment groups
Active Control
Placebo Group
Group I: dose 1Active Control1 Intervention
BP cuff bilateral arm compression to 50 mmHg above systolic BP for 2.5 minutes on/off for 4 cycles every other day.
Group II: dose 3Active Control1 Intervention
BP cuff bilateral arm compression to 50 mmHg above systolic BP for 5 minutes on/off once daily.
Group III: dose 2Active Control1 Intervention
BP cuff bilateral arm compression to 50 mmHg above systolic BP for 5 minutes on/off for 4 cycles every other day.
Group IV: dose 4Active Control1 Intervention
BP cuff bilateral arm compression to 50 mmHg above systolic BP for 5 minutes on/off twice daily.
Group V: shamPlacebo Group1 Intervention
BP cuff bilateral arm compression to 50 mmHg.

Find a Location

Who is running the clinical trial?

Georgia Rehabilitation InstituteUNKNOWN
Augusta UniversityLead Sponsor
211 Previous Clinical Trials
85,028 Total Patients Enrolled
Carol Smith, RNStudy DirectorWellstar MCG Health

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study
Askiel Bruno 2020. "Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06179797.
All > Columbia
~9 spots leftby Apr 2025
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