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Procedure

RIPC for Acute Kidney Injury (BRICK Trial)

N/A

Waitlist Available

Led By Oladipupo Olafiranye, MD

Research Sponsored by Oladipupo Olafiranye, MD, MS

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Referral for cardiac catheterization and percutaneous coronary intervention

Patient with non-ST elevation myocardial infarction or unstable angina

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 month and 6 months

Awards & highlights

BRICK Trial Summary

This trial is studying whether a treatment called remote ischemic preconditioning can help prevent contrast-induced acute kidney injury in people with non-ST elevation myocardial infarction and unstable angina.

Who is the study for?

This trial is for patients with non-ST elevation myocardial infarction or unstable angina who are scheduled for heart-related procedures and have a high risk of kidney injury from contrast media. It's not suitable for those unable to consent, with very high or low blood pressure, contrast allergies, upper limb vascular disease, existing severe kidney issues requiring dialysis, or those with certain types of vascular access points.Check my eligibility

What is being tested?

The study is testing the effectiveness of Remote Ischemic Pre-Conditioning (RIPC) versus a sham procedure (Sham-RIPC) in preventing kidney damage after exposure to contrast media during cardiac catheterization and stent placement. Participants will be randomly assigned to one of these two groups without knowing which one they're in.See study design

What are the potential side effects?

Since RIPC involves briefly restricting blood flow to limbs using a cuff, potential side effects may include discomfort in the limb where the cuff is applied. The sham procedure should have no side effects as it mimics RIPC without actually restricting blood flow.

BRICK Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am referred for a procedure to check and treat heart artery blockages.

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I have had a heart attack without ST elevation or unstable chest pain.

BRICK Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 month and 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 month and 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Contrast-induced acute kidney injury

Secondary outcome measures

Biomarkers study

Major Adverse Cardiovascular Event

Major Adverse Kidney Event

BRICK Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: RIPC GroupActive Control1 Intervention

3 cycles of blood pressure cuff inflations to occlusive pressure of 200 mmHg for 5 minutes and deflation for 5 minutes

Group II: Sham-RIPC GroupPlacebo Group1 Intervention

3 cycles of blood pressure cuff inflations to non-occlusive pressure of 10 mmHg for 5 minutes and deflation for 5 minutes (Control)

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Oladipupo Olafiranye, MD, MSLead Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,357 Previous Clinical Trials

4,315,076 Total Patients Enrolled

24 Trials studying Acute Kidney Injury

26,690 Patients Enrolled for Acute Kidney Injury

Oladipupo Olafiranye, MDPrincipal Investigator - University of Pittsburgh

University of Pittsburgh

1 Previous Clinical Trials

240 Total Patients Enrolled

1 Trials studying Acute Kidney Injury

240 Patients Enrolled for Acute Kidney Injury

Media Library

RIPC (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT03236441 — N/A

Acute Kidney Injury Research Study Groups: RIPC Group, Sham-RIPC Group

Acute Kidney Injury Clinical Trial 2023: RIPC Highlights & Side Effects. Trial Name: NCT03236441 — N/A

RIPC (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03236441 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment currently open for this trial?

"Affirmative, the public data on clinicaltrials.gov shows that this research study is currently in search of participants. Initially posted on March 5th 2018 and last updated August 14th 2022, it requires 110 volunteers to be recruited from 3 different sites."

Answered by AI

What is the total enrollment figure for this trial?

"Affirmative. Per the information hosted on clinicaltrials.gov, this research undertaking is actively seeking candidates to enroll in the trial since its inception on March 5th 2018 and most recent update from August 14th 2022. This study seeks to recruit 110 patients across 3 sites."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury

Oladipupo Olafiranye, MD, MS 2018. "Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03236441.

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