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RIC once per day for Vascular Cognitive Impairment (TRIC-VCI Trial)

Q: Is the sample population of this research encompassing individuals aged sixty and above?

<p>The requirements for participation in this clinical trial mandate that applicants must fall within the age range of 60 to 85 years old. 57 trials are available for minors, and 937 studies offer enrollment opportunities to seniors.</p>

Q: Has the FDA sanctioned twice-daily administration of RIC?

<p>Our team has awarded RIC twice per day a rating of 2 due to the Phase 2 trial status, meaning there is sufficient evidence for safety but insufficient data on efficacy.</p>

Phase 2

Waitlist Available

Led By Eric Smith, MD

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 days and 90 days

Awards & highlights

TRIC-VCI Trial Summary

This trial will test whether RIC is a tolerable and effective treatment for patients with cognitive impairment due to cerebral small vessel disease.

Eligible Conditions

Vascular Cognitive Impairment
Cerebral Small Vessel Disease
Vascular Dementia

TRIC-VCI Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30 days and 90 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30 days and 90 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adherence

Secondary outcome measures

Arm deep venous thrombosis

Discontinuation

Global cognition

+8 more

TRIC-VCI Trial Design

2Treatment groups

Active Control

Group I: RIC once per dayActive Control1 Intervention

RIC performed once a day on one arm. Each RIC session will consist of 4 cycles of unilateral or simultaneous bilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes. The procedure will be performed by using an electric auto-control device with cuffs that inflate to a pressure of 200 mmHg during the ischemic period.

Group II: RIC twice per dayActive Control1 Intervention

RIC performed twice a day on one arm, approximately 12 hours apart. Each RIC session will consist of 4 cycles of unilateral or simultaneous bilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes. The procedure will be performed by using an electric auto-control device with cuffs that inflate to a pressure of 200 mmHg during the ischemic period.

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Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV

1,340 Previous Clinical Trials

26,452,674 Total Patients Enrolled

Canadian Consortium on Neurodegeneration in AgingOTHER

3 Previous Clinical Trials

3,050 Total Patients Enrolled

University of CalgaryLead Sponsor

791 Previous Clinical Trials

868,710 Total Patients Enrolled

1 Trials studying Vascular Cognitive Impairment

24 Patients Enrolled for Vascular Cognitive Impairment

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial currently have any available openings for participants?

"Per the information on clinicaltrials.gov, this research trial is actively seeking participants. The study was made public on September 26th 2019 and its details were recently updated June 7th 2022."

Answered by AI

What is the current size of the cohort engaging in this research?

"Affirmative - the online data hosted on clinicaltrials.gov demonstrates that this medical trial is currently enrolling, with its first posting being dated September 26th 2019 and last updated June 7th 2022. Qualified candidates are sought from 1 centre for a total of 24 patients."

Answered by AI

Is participation in this trial available for individuals?

"This medical trial is seeking 24 seniors between the ages of 60 and 85 with cerebral small vessel diseases. In order to qualify, participants must demonstrate independence in completing basic activities of daily living (responding positively to questions 2, 4, 5, 6, 7 8 9 and 14 on Bristol ADL scale), have visible evidence of CSVD on MRI or CT scans such as confluent white matter hypodensities/hyperintensities (ARWMC Scale) or two+ supratentorial infarcts; score <25 on Montreal Cognitive Assessment Test; exhibiting a noticeable decline from their previous cognitive functioning level according to patients"

Answered by AI

Is the sample population of this research encompassing individuals aged sixty and above?

"The requirements for participation in this clinical trial mandate that applicants must fall within the age range of 60 to 85 years old. 57 trials are available for minors, and 937 studies offer enrollment opportunities to seniors."

Answered by AI

Has the FDA sanctioned twice-daily administration of RIC?

"Our team has awarded RIC twice per day a rating of 2 due to the Phase 2 trial status, meaning there is sufficient evidence for safety but insufficient data on efficacy."

Answered by AI

Recent research and studies

BMJ OpenJournal

Trial of Remote Ischaemic Preconditioning in Vascular Cognitive Impairment (TRIC-VCI): Protocol

Ganesh, Aravind, Philip Barber, Sandra E Black, Dale Corbett, Thalia S Field, Richard Frayne, Vladimir Hachinski, et al.. 2020. “Trial of Remote Ischaemic Preconditioning in Vascular Cognitive Impairment (TRIC-VCI): Protocol”. BMJ Open. BMJ. doi:10.1136/bmjopen-2020-040466.

clinicaltrials.govStudy

Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment

2019. "Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04109963.

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