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Head of Bed Positioning for Ischemic Stroke (ZODIAC Trial)

Phase 3

Waitlist Available

Led By Anne W Alexandrov, PhD

Research Sponsored by University of Tennessee Health Science Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured every 10 minutes from initiation of positioning up until thrombectomy commences or 2 hours - whichever comes first

Awards & highlights

ZODIAC Trial Summary

This trial is testing whether placing the head of bed at 0-degrees can improve blood flow to the brain in patients with ischemic stroke, reducing stroke symptom worsening.

Eligible Conditions

Ischemic Stroke
Stroke

ZODIAC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured every 10 minutes from initiation of positioning up until thrombectomy commences or 2 hours - whichever comes first

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured every 10 minutes from initiation of positioning up until thrombectomy commences or 2 hours - whichever comes first

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured every 10 minutes from initiation of positioning up until thrombectomy commences or 2 hours - whichever comes first for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Early Neurologic Deterioration (END) on the National Institute of Health Stroke Scale Occurring During the Positioning Intervention

Secondary outcome measures

Diagnosis of Pneumonia Made During Hospitalization in a Patient Free From Pneumonia at Time of Hospital Admission

Modified Rankin Scale Score at 90-days from Stroke Onset

Modified Rankin Scale Score at Hospital Discharge or Day 7

+3 more

ZODIAC Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Zero Degree HOBExperimental Treatment1 Intervention

Randomization to zero degree head of bed positioning until the time of initiation of thrombectomy

Group II: Thirty Degree HOBActive Control1 Intervention

Randomization to thirty degree head of bed positioning until the time of initiation of thrombectomy

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Tennessee Health Science CenterLead Sponsor

48 Previous Clinical Trials

24,922 Total Patients Enrolled

University of TennesseeLead Sponsor

188 Previous Clinical Trials

141,459 Total Patients Enrolled

National Institute of Nursing Research (NINR)NIH

579 Previous Clinical Trials

10,376,200 Total Patients Enrolled

1 Trials studying Ischemic Stroke

50 Patients Enrolled for Ischemic Stroke

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers still signing up participants for this clinical trial?

"The most recent data from clinicaltrials.gov tells us that this trial is still looking for participants. The study was first advertised on September 25th, 2018 and has been updated as recently as March 28th, 2020."

Answered by AI

Has the FDA cleared Head of Bed Positioning for therapeutic use?

"There is some evidence to suggest that Head of Bed Positioning is effective and safe, so it received a score of 3."

Answered by AI

In how many different locations are these tests being conducted?

"This study is presently being run out of 11 sites. The locations are located in Mobile, Tulsa and Los Angeles along with other 8 locations. To minimize travel demands, please select the clinic closest you to if you participate."

Answered by AI

How many people are signing up for this clinical trial?

"That is correct. The information on clinicaltrials.gov does suggest that the trial is looking for patients as it was last updated on 3/28/2020 and 182 patients are needed between 11 sites"

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke

Anne Alexandrov 2018. "Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03728738.

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