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Treatment algorithm for Mitral Valve Regurgitation

Q: Is this experiment currently recruiting participants?

<p>Derived from clinicaltrials.gov, this research is not accepting any more volunteers at the present moment. The first posting was on January 16th 2018 and it has seen its latest update on March 25th 2021. Nevertheless, 103 other trials are looking for participants now.</p>

N/A

Waitlist Available

Led By Vincent Chan, MD

Research Sponsored by Ottawa Heart Institute Research Corporation

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Severe ischemic mitral valve regurgitation

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months after surgery

Awards & highlights

Study Summary

This trialtests if a specific method of deciding whether to repair or replace the mitral valve can improve outcomes in IMR.

Who is the study for?

This trial is for adults who can consent and have severe ischemic mitral valve regurgitation, a heart condition where the valve leaks due to coronary artery disease. It's not for those with mixed valve issues or acute cases of this condition.Check my eligibility

What is being tested?

The study compares two approaches: one group gets standard care (valve repair/replacement based on surgeon choice), while the other follows a treatment algorithm deciding between repair or replacement based on specific measurements of the mitral valve.See study design

What are the potential side effects?

Since this trial involves surgical procedures, potential side effects include typical surgery risks such as infection, bleeding, reactions to anesthesia, and complications related to heart surgeries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have severe leakage in my heart's mitral valve due to poor blood supply.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 12 months after surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 12 months after surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 12 months after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Left ventricle end-systolic volume indexed to body surface area

Secondary outcome measures

Change in indexed left atrial volume

Change in right ventricle systolic pressure

Major adverse events

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Treatment algorithmExperimental Treatment1 Intervention

Mitral valve will be replaced if posterior leaflet tethering angle >=25 degrees. Mitral valve will be repaired if posterior leaflet tethering angle <25 degrees

Group II: No treatment algorithmActive Control1 Intervention

Mitral valve will be repaired or replaced at surgeon's discretion.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ottawa Heart Institute Research CorporationLead Sponsor

188 Previous Clinical Trials

92,326 Total Patients Enrolled

Vincent Chan, MDPrincipal InvestigatorOttawa Heart Institute Research Corporation

10 Previous Clinical Trials

1,123 Total Patients Enrolled

Media Library

Treatment Algorithm Clinical Trial Eligibility Overview. Trial Name: NCT03292497 — N/A

Mitral Valve Regurgitation Research Study Groups: Treatment algorithm, No treatment algorithm

Mitral Valve Regurgitation Clinical Trial 2023: Treatment Algorithm Highlights & Side Effects. Trial Name: NCT03292497 — N/A

Treatment Algorithm 2023 Treatment Timeline for Medical Study. Trial Name: NCT03292497 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment currently recruiting participants?

"Derived from clinicaltrials.gov, this research is not accepting any more volunteers at the present moment. The first posting was on January 16th 2018 and it has seen its latest update on March 25th 2021. Nevertheless, 103 other trials are looking for participants now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation

2018. "Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03292497.

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