Smoking Cessation Clinical Trials
Smoking Cessation studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect smoking cessation clinical trial.
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Smoking Cessation
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Clinical Trials
Smoking Cessation Clinical Trials
Phase-Based Estimates
1
Effectiveness
1
Safety
Smoking Cessation Counseling And Food Delivery
for Tobacco Dependence
Little Rock, AR
18+
All Sexes
Waitlist Available
Little Rock, AR
18+
All Sexes
The long-term goal of FRESH Delivers is to fill a critical gap in knowledge on the role of a home-based food delivery social intervention in the elimination of tobacco-caused cancer health disparities. The central hypothesis is that smokers who receive real-time video-based motivational counseling and home-based food deliveries will have greater cotinine-verified 7-day point prevalence abstinence than those who receive real-time video-based motivational counseling alone or home food delivery alone. The rationale for this approach is that studies show increased odds of smoking cessation with increasing food security.
Phase-Based Estimates
1
Effectiveness
1
Safety
Self-Regulation Strategies + Large Changes (SR)
for Obesity
Providence, RI
18+
All Sexes
Recruiting
Providence, RI
18+
All Sexes
The purpose of this study is to determine the efficacy, acceptability, and feasibility of an intervention that provides a behavioral weight gain prevention intervention in advance of smoking cessation treatment in individuals with overweight or obesity who smoke cigarettes. The primary aim of this study is to determine feasibility and acceptability and initial efficacy regarding whether preceding 8 weeks of smoking cessation treatment with 8 weeks of self-regulation strategies + large changes for weight gain prevention (SR), compared to 8 weeks of healthy lifestyle education (LE), will result in greater smoking cessation and reduced weight gain. Secondary aims are to study effects on self-efficacy for managing weight and for quitting smoking, negative affect, and delayed reward discounting. Methods: Individuals with overweight or obesity who smoke cigarettes will participate in a 16-week group-based multiple health behavior change intervention. Groups will be randomly assigned to receive either 8 weeks of SR followed by 8 weeks of smoking cessation treatment or 8 weeks of LE followed by 8 weeks of smoking cessation treatment. Smoking cessation treatment in both conditions will include counseling and combination nicotine replacement therapy (patch + lozenges), with a quit day at week 9 of the 16-week intervention. Assessments will occur at baseline, on quit day and 1, 2, and 3 months later. Determining the viability of this strategy in terms of effects on both smoking and weight has high significance to public health.
Phase-Based Estimates
1
Effectiveness
2
Safety
Kava
for Smoking
Gainesville, FL
18+
All Sexes
Phase 2
Recruiting
Gainesville, FL
18+
All Sexes
Tobacco use is the leading cause of many preventable diseases, particularly lung cancer. Based on the national cancer data in 2020, Florida has the highest lung cancer incidence (18,150 cases) with the most deaths (10,580 deaths) among all the states in the United States. Unfortunately, around 16% of adults in Florida continue to smoke cigarettes due to its addictive nature and the limited success of current cessation strategies. Therefore, there is an unmet and urgent need for novel interventions to improve the success of tobacco cessation. If such an intervention can reduce tobacco-associated lung carcinogenesis, that will be more desirable. The ultimate goal of this study is to develop a safe and effective kava-based intervention to enable tobacco cessation and reduce lung cancer risk, which will improve the health of Floridians. This study will evaluate the compliance with a daily kava regimen among active smokers who have no intention to quit smoking. This study will also investigate whether kava use can reduce tobacco use and dependence, as well as tobacco-associated lung carcinogenesis.
Phase-Based Estimates
1
Effectiveness
1
Safety
LTQ
for Mental Disorders
Baltimore, MD
18+
All Sexes
Waitlist Available
Baltimore, MD
18+
All Sexes
This study is evaluating whether an app can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Smartphone-based Financial Incentives
for Smoking, Cessation
Burlington, VT
18+
Female
Recruiting
Burlington, VT
18+
Female
This study is evaluating whether a smartphone-based incentives intervention can help pregnant AN women quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
ITBS
for HIV Infections
Lexington, KY
18 - 65
All Sexes
Recruiting
Lexington, KY
18 - 65
All Sexes
This study is evaluating whether a brain stimulation technique can help people with HIV/AIDS quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
EMB-001
for Tobacco Dependence
Raleigh, NC
18+
All Sexes
Phase 1 & 2
Recruiting
Raleigh, NC
18+
All Sexes
This study is evaluating whether a combination of drugs can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
QL Marijuana Check-Up Intervention (QL-MJCU)
for Marijuana Use
Seattle, WA
18+
All Sexes
Recruiting
Seattle, WA
18+
All Sexes
Smoking cigarettes remains the number one preventable cause of death and disease in the US. Smokers who call tobacco quitlines and use marijuana struggle to quit tobacco due to the interactive effects of nicotine and marijuana. A recent study found that 25% of callers to state quitlines said they were using marijuana and 44% of those were interested in quitting or cutting back their marijuana use (in addition to wanting to quit smoking). The investigators propose to develop an integrated intervention for co-users of marijuana and tobacco to be delivered via state-funded quitlines. The investigators will incorporate key elements of an evidence-based brief behavioral intervention called 'The Marijuana Check-Up' into the tobacco quitline treatment. The investigators will evaluate the feasibility, acceptability and preliminary effects of the new intervention in a small randomized pilot study with 100 co-users recruited from four participating state quitlines. Outcomes measured at 3 months post randomization will include tobacco abstinence (biochemically verified) and days used marijuana. The investigators hypothesize that the intervention will: (1) be feasible to deliver (measured by coach treatment fidelity scores); (2) be acceptable to co-users (measured by enrollments into the study and call completion numbers); (3) increase tobacco cessation rates compared with standard quitline treatment; (4) increase co-users motivation to change MJ use; and (5) produce greater reduction in days using MJ compared with standard quitline treatment. The proposed brief behavioral intervention addressing co-use may increase quitline callers' chances of achieving and maintaining tobacco abstinence and increase participants' motivation to reduce marijuana use. As non-medicinal marijuana use becomes common and legal in more states, a low touch phone and web-based intervention for co-users of marijuana and tobacco could improve health outcomes for many. Findings will inform development of scalable public health intervention strategies for co-users easily implemented across quitlines.
Phase-Based Estimates
1
Effectiveness
1
Safety
Tailored Text Message Program
for Smoking, Cessation
Boston, MA
18+
All Sexes
Recruiting
Boston, MA
18+
All Sexes
The goal of this randomized controlled trial (RCT) is to test whether a smoking cessation induction intervention delivered during a dental cleaning appointment increases the utilization of evidence-based treatments (EBTs) for smoking cessation within 7 months post-dental cleaning appointment. Approximately 400 cigarette smokers who are scheduled for a dental cleaning appointment at the Boston University Goldman School of Dental Medicine (BUGSDM) patient treatment center will be recruited and enrolled. Participants will be randomized to either the intervention or control group
Phase-Based Estimates
1
Effectiveness
1
Safety
Proactive Outreach
for Chronic Disease
Minneapolis, MN
18+
All Sexes
Waitlist Available
Minneapolis, MN
18+
All Sexes
This study is evaluating whether a program that uses electronic methods to reach out to smokers with COPD can help them quit.
Phase-Based Estimates
2
Effectiveness
3
Safety
Positively Me
for Smoking, Cigarette
Tampa, FL
18+
All Sexes
Phase 3
Recruiting
Tampa, FL
18+
All Sexes
This study is evaluating whether a smoking cessation program designed for people living with certain chronic conditions and delivered via videoconferencing groups works better than a control condition--a program that is not
Phase-Based Estimates
3
Effectiveness
3
Safety
Training
for Tobacco-Related Carcinoma
Columbus, OH
18 - 65
All Sexes
Phase 4
Recruiting
Columbus, OH
18 - 65
All Sexes
This study is evaluating whether a multi-level smoking cessation program for high-risk women in rural communities may help decrease the rates of cervical cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
QuitBot Smoking Cessation Program
for Cigarette Smoking-Related Carcinoma
Seattle, WA
18+
All Sexes
Phase 3
Waitlist Available
Seattle, WA
18+
All Sexes
This phase III trial compares two remote digital smoking cessation programs to see how well they work for quitting smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
Varenicline
for Manic Disorder
La Jolla, CA
18+
All Sexes
Phase 4
Recruiting
La Jolla, CA
18+
All Sexes
This study is evaluating whether a lower dose of varenicline may be more effective for individuals with bipolar disorder, schizophrenia or schizoaffective disorder.
Phase-Based Estimates
1
Effectiveness
1
Safety
Mindfulness-Oriented Recovery Enhancement (MORE)
for Tobacco Dependence
Columbia, MO
18+
All Sexes
Recruiting
Columbia, MO
18+
All Sexes
This study is evaluating whether two behavioral interventions may help smokers quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Mobile Contingency Management
for Smoking, Cessation
Oklahoma City, OK
18+
All Sexes
Waitlist Available
1 Prior Treatment
Oklahoma City, OK
18+
All Sexes
This study is evaluating whether a new approach to mobile phone based contingency management may help individuals quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Proactive Telephone Counseling From VA Quitline
for Lung Diseases
Providence, RI
18+
All Sexes
Recruiting
Providence, RI
18+
All Sexes
This study is evaluating whether providing smokers with support to quit smoking will help them quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Tech-Facilitated IC Intervention
for Smoking, Cessation
San Francisco, CA
18 - 65
All Sexes
Recruiting
San Francisco, CA
18 - 65
All Sexes
This study is evaluating whether a telephone and mobile technology based intervention can help veterans with PTSD quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Staff Training And Academic Detailing
for Tobacco Use
New York, NY
Any Age
All Sexes
Waitlist Available
New York, NY
Any Age
All Sexes
This study is evaluating whether an opt-out approach to referring smokers to treatment is more effective than an opt-in approach.
Phase-Based Estimates
1
Effectiveness
2
Safety
Very Low Nicotine Content (VLNC) Cigarettes
for Smoking, Cessation
Tampa, FL
18+
All Sexes
Phase 2
Waitlist Available
Tampa, FL
18+
All Sexes
This study is evaluating whether a targeted intervention will help people to stop or reduce smoking better than a standard intervention using very low nicotine content (VLNC) cigarettes, and to determine the optimal nicotine tapering schedule (gradual vs. immediate) during a 5-week pre-quit period.
Phase-Based Estimates
1
Effectiveness
1
Safety
Voucher-based Incentives
for Cigarette Smoking Antepartum and Early Postpartum.
Burlington, VT
18 - 65
Female
Waitlist Available
Stage II
Burlington, VT
18 - 65
Female
This study is evaluating whether a voucher-based incentive program can help pregnant women quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Smoke Free Smartphone Application
for Cigarette Smoking-Related Carcinoma
San Francisco, CA
18+
All Sexes
Waitlist Available
San Francisco, CA
18+
All Sexes
This study evaluates the effects of a video game embedded in a commercially available mobile application (app) for smoking cessation. Smokers are increasingly turning to mobile health apps for assistance with quitting smoking, and there is a critical need for strategies to engage app users to increase retention and efficacy. Video games are designed to increase users' motivation and engagement, which in turn may increase their exposure and adherence to a smoking cessation program. The hypothesis is that the game increases engagement, retention, and smoking abstinence rates compared with a core version of the app without the game. A two-arm individually randomized pilot trial of 500 adult smokers will test this hypothesis, comparing outcomes for participants randomized to receive the core app plus embedded game with participants randomized to receive the core app only. Primary outcomes relate to user engagement with the app. Secondary outcomes relate to user engagement, efficacy (smoking abstinence), and user satisfaction.
Phase-Based Estimates
1
Effectiveness
1
Safety
MindCotine's VR App
for Smoking, Cessation
Palo Alto, CA
18+
All Sexes
Recruiting
Palo Alto, CA
18+
All Sexes
This study aims to see how feasible a mobile app based virtual reality program for smoking cessation (MindCotine) would be among Stanford cancer center patients
Phase-Based Estimates
1
Effectiveness
2
Safety
Centanafadine
for Smoking, Cessation
Raleigh, NC
18+
All Sexes
Phase 2
Recruiting
Raleigh, NC
18+
All Sexes
This study is evaluating whether a drug called centanafadine can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Offered Nicotine Replacement Therapy
for HIV Infections
Boston, MA
18+
All Sexes
Waitlist Available
Boston, MA
18+
All Sexes
This study is evaluating whether a smoking cessation program called Quit for Life is effective for people with HIV who smoke.
Phase-Based Estimates
1
Effectiveness
1
Safety
Informational Intervention
for Tobacco-Related Carcinoma
Portland, OR
18+
All Sexes
Waitlist Available
Portland, OR
18+
All Sexes
This study is evaluating whether a Quitline referral system can increase smoking cessation assistance and quit rates.
Phase-Based Estimates
1
Effectiveness
1
Safety
Self-help Materials
for Smoking, Cigarette
Atlanta, GA
18+
All Sexes
Recruiting
Atlanta, GA
18+
All Sexes
This study is evaluating whether a mindfulness-based text messaging program can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Support Person Written Materials
for Smoking, Cessation
Minneapolis, MN
18+
All Sexes
Recruiting
Minneapolis, MN
18+
All Sexes
This study is evaluating whether a nicotine patch may help smokers quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Adaptive Treatment
for Smoking, Cessation
Houston, TX
18+
All Sexes
Waitlist Available
Houston, TX
18+
All Sexes
This study is evaluating whether a computer program can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Enhanced Care
for Smoking, Cessation
Chester, SC
18+
All Sexes
Waitlist Available
Chester, SC
18+
All Sexes
This study is evaluating whether a program which helps patients quit smoking will be effective in psychiatric patients.
Phase-Based Estimates
1
Effectiveness
1
Safety
Remote Smoking Cessation Bundle
for Smoking, Cessation
New Westminster, Canada
18+
All Sexes
Recruiting
New Westminster, Canada
18+
All Sexes
This study is evaluating whether a smoking cessation bundle can be delivered remotely and whether it can reduce smoking rates and postoperative complications.
Phase-Based Estimates
1
Effectiveness
1
Safety
BecomeAnEX
for Mental Disorders
Baltimore, MD
18+
All Sexes
Recruiting
Baltimore, MD
18+
All Sexes
This study is evaluating whether a digital intervention may help people with serious mental illness remain abstinent from smoking.
Phase-Based Estimates
1
Effectiveness
2
Safety
Varenicline
for Smoking, Cessation
New Haven, CT
18+
All Sexes
Phase 2
Recruiting
New Haven, CT
18+
All Sexes
This study is evaluating whether a new treatment for nicotine addiction may be effective.
Phase-Based Estimates
1
Effectiveness
1
Safety
Augmented Reality 1
for Smoking
Tampa, FL
18+
All Sexes
Waitlist Available
Tampa, FL
18+
All Sexes
This study is evaluating whether a new augmented reality program may help individuals quit smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
Group MT Sessions
for Tobacco Smoking Behavior
Miami, FL
18 - 65
All Sexes
Phase 4
Recruiting
Miami, FL
18 - 65
All Sexes
This study is evaluating whether a mindfulness-based smoking cessation program may help improve smoking cessation rates for cancer survivors.
Phase-Based Estimates
1
Effectiveness
1
Safety
Repetitive Transcranial Magnetic Stimulation
for Relapse
Buffalo, NY
18+
All Sexes
Recruiting
Grade I
Buffalo, NY
18+
All Sexes
This study is evaluating whether rTMS can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Mindfulness Based Relapse Prevention - Smoking And Alcohol
for Alcohol Drinking
Tampa, FL
18+
All Sexes
Waitlist Available
1 Prior Treatment
Tampa, FL
18+
All Sexes
This study is evaluating whether a medication can help people reduce their alcohol use and quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Genotype-guided Therapy
for Coronary Artery Disease
Saint Louis, MO
18+
All Sexes
Waitlist Available
Saint Louis, MO
18+
All Sexes
This study is evaluating whether a genetic test can help determine which patients with coronary artery disease should receive nicotine replacement therapy.
Phase-Based Estimates
3
Effectiveness
3
Safety
Carotid Artery Compliance And Stiffness
for Emphysema
Iowa City, IA
18+
All Sexes
Phase 4
Recruiting
Iowa City, IA
18+
All Sexes
This study is evaluating whether a medication may help reduce the risk of developing emphysema.
Phase-Based Estimates
1
Effectiveness
1
Safety
Contingency Management
for Tobacco Dependence
New York, NY
18 - 65
All Sexes
Recruiting
New York, NY
18 - 65
All Sexes
This project aims to develop electroretinogram as a new putative marker for dopamine release, and as a predictor of treatment response among patients seeking treatment for smoking cessation. Tobacco smoking continues to be a major public health challenge. Dopamine is a neurotransmitter released in the brain. Several lines of evidence suggest that dopamine release deficit in the brain is involved in the development and maintenance of nicotine dependence. The investigators hypothesize that smokers who do not have a deficit in dopamine release will more readily respond to behavioral treatment for smoking cessation, and in particular, financial incentives contingent on abstinence (Contingency Management). Previous pilot data suggest electroretinogram (ERG), which records electrical signals from the retina in response to light, is a clinically accessible correlate to dopamine release in the brain. The project proposes an ERG-based biomarker, and a pilot clinical trial to apply this biomarker to personalize smoking cessation treatment. This clinically tractable biomarker of central dopamine release may have a large number of future applications in the diagnosis and treatment of other mental illnesses and substance use disorders. The study will recruit normal controls and smokers, measure ERG before and after a standard dose of oral immediate release methylphenidate. Smokers will undergo a 12-week standardized treatment course of CM. The investigators will test whether smoking status and the response to CM are correlated to changes in ERG in response to methylphenidate challenge.
Phase-Based Estimates
1
Effectiveness
1
Safety
Spanish-Language Version Of The Stop Smoking For Good
for Smoking, Cessation
Tampa, FL
18+
All Sexes
Waitlist Available
Tampa, FL
18+
All Sexes
This study is evaluating whether a smoking cessation intervention can be translated into Spanish and be effective for Spanish-speaking smokers.
Phase-Based Estimates
1
Effectiveness
1
Safety
Motivational And Behavioral Counseling
for Head and Neck Cancer
Houston, TX
18+
All Sexes
Phase < 1
Waitlist Available
Houston, TX
18+
All Sexes
This study is evaluating whether Acceptance and Commitment Therapy is more effective than Motivational and Behavioral Counseling in helping patients to stop smoking.
Phase-Based Estimates
1
Effectiveness
2
Safety
QuitAdvisorMD Software Algorithm
for Smoking
Charlottesville, VA
Any Age
All Sexes
Phase 2
Waitlist Available
Charlottesville, VA
Any Age
All Sexes
QuitAdvisorMD: A point-of-care tool for brief smoking cessation interventions Under a Phase II SBIR grant supported by NIH/NIDA, we are developing QUITAdvisorMD: a point-of-care, patient-centered resource for counseling patients who smoke or use tobacco products. It is based on the principles of Motivational Interviewing, a non-confrontational and very effective method for intervening and treating these patients; the 5 A's of behavioral interventions; and the Transtheoretical Model of Change. Through a point and click interface, the tool uses a series of interview questions designed to motivate patients to stop smoking by first assessing their stage of change and then offering effective stage-based interventions and interview techniques. The tool also offers stage-tailored patient information, a clinician educational reference, and the ability to communicate support information patients via email and/or text message.
Phase-Based Estimates
3
Effectiveness
3
Safety
Varenicline
for Smoking
Toronto, Canada
18+
All Sexes
Phase 4
Waitlist Available
Toronto, Canada
18+
All Sexes
This study is a randomized, double-blind, placebo-controlled clinical trial which evaluates the efficacy of preoperative smoking counseling and varenicline (a medication approved by Health Canada and FDA for quitting smoking) to provide long term smoking cessation (i.e., abstinence for at least one year) in surgical patients. The primary hypothesis is as follows: "A significant percentage of surgical patients will be receptive to smoking cessation interventions in the pre-admission clinic and will refrain from smoking at 24 and 52 weeks after starting the treatment." The secondary hypothesis is as follows: "Patients who receive interventions but do not quit smoking will have reduced number of cigarettes consumed/day or improved their readiness to quit smoking at 24 and 52 weeks after starting the treatment."
Phase-Based Estimates
1
Effectiveness
1
Safety
Hospital Counseling + Nicotine Replacement + Presurgical Scheduled Reduced Smoking, Questionaires
for Newly Diagnosed Cancer Patients
New York, NY
18+
All Sexes
Waitlist Available
Metastatic
New York, NY
18+
All Sexes
This study is evaluating whether a program of counseling and use of nicotine patch can help people quit tobacco use before surgery.
Phase-Based Estimates
1
Effectiveness
1
Safety
Headspace
for Smoking, Cessation
Los Angeles, CA
18+
All Sexes
Recruiting
Los Angeles, CA
18+
All Sexes
Participants will complete this study remotely, either at home or at their preferred location using an online platform. The investigators propose to test the effects of a mindfulness training [MT: Headspace] intervention compared to a time and attention psycho-education control [control: TedTalks] among N=200 adult smokers of a nicotine product. Previous studies suggest that mindfulness training may be beneficial in reducing craving during tobacco abstinence. During the study, participants will complete baseline questionnaires, followed by two weeks of daily MT or control training and self-report on questionnaires assessing affect, cognition, and smoking behavior using Ecological Momentary Assessment (EMA) for remote data capture. Following this two weeks of training, participants will complete a smoking quit attempt and complete daily EMA questionnaires for two weeks. The first day of the smoking quit attempt will include a remote Zoom video session following overnight smoking abstinence. During this session the participants will complete a remote stressor task (Trier Social Stress Test, TSST), and the investigators will collect EMA data on affect and smoking behavior before and after the TSST. One month after the start of the quit attempt, participants will complete a phone call as a follow-up to assess smoking behavior over the previous 30 days, and to complete a debriefing. Study objectives are to test the effect of MT on: (1) smoking lapses during the follow-up periods; and (2) stress (affect, smoking urge, withdrawal symptoms) during the TSST.
Phase-Based Estimates
1
Effectiveness
1
Safety
Food Assistance And Cessation Resources Navigation Plus Economic Assistance
for Food Insecurity
Cleveland, OH
18+
All Sexes
Waitlist Available
Cleveland, OH
18+
All Sexes
This is a two-arm randomized controlled study with 60 participants. The study has two aims. The first aim is to determine the feasibility and acceptability of a food assistance intervention to alleviate food insecurity during a smoking cessation attempt among low-income smokers with food insecurity. Smokers with recent food insecurity are recruited for a 12-week study that involves resources navigation for food assistance and tobacco cessation, with assessments at baseline and at 12 weeks. Participants are randomized to receive economic assistance for food in addition to resources navigation in the intervention arm, or randomized to receive resources navigation only in the control arm. The second aim is to estimate the preliminary impact of the intervention on food insecurity and tobacco cessation measures at 12 weeks.
Phase-Based Estimates
1
Effectiveness
1
Safety
Abstinent Contingent (AC) Re-Connect
for Nicotine Dependence, Cigarettes
Glassboro, NJ
18+
All Sexes
Recruiting
Glassboro, NJ
18+
All Sexes
This series of studies will explore the acceptability, feasibility, and preliminary efficacy of making access to smartphone applications contingent on objective evidence of smoking abstinence.
Phase-Based Estimates
2
Effectiveness
3
Safety
Nicotine Replacement Therapy Agent - Patches
for Smoking
New York, NY
18+
All Sexes
Phase 3
Waitlist Available
New York, NY
18+
All Sexes
This study conduct a two-arm, parallel-group randomized controlled trial. The study will recruit and randomize 900 smokers (n=450 per arm) to either: (1) Control: Standard Smoking Cessation Counseling or (2) Intervention: Integrated Financial-Smoking Cessation Counseling.
Phase-Based Estimates
1
Effectiveness
1
Safety
Integrated Intervention Of Smoking Cessation And Breastfeeding
for Smoking, Cigarette
Buffalo, NY
18+
Female
Recruiting
Buffalo, NY
18+
Female
This study is evaluating whether a combination of smoking cessation and breastfeeding interventions can improve both smoking cessation and breastfeeding rates.
Phase-Based Estimates
1
Effectiveness
1
Safety
Standard Care
for Tobacco Smoking Behavior
Oklahoma City, OK
18+
All Sexes
Waitlist Available
Oklahoma City, OK
18+
All Sexes
This study is evaluating whether offering small financial incentives for smoking cessation counseling and biochemically-verified smoking abstinence at follow-up might be effective in helping people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
SmokefreeTXT
for Smoking, Cessation
Charlottesville, VA
18+
All Sexes
Recruiting
Charlottesville, VA
18+
All Sexes
This study is evaluating whether a text messaging program can help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Telephone-Based Intervention
for Cigarette Smoking-Related Carcinoma
Houston, TX
18+
Female
Recruiting
1 Prior Treatment
Houston, TX
18+
Female
This study is evaluating whether a smoking cessation program can help pregnant women quit smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
Contingency Management Smoking Cessation Intervention
for HIV Infections
Miami, FL
18+
All Sexes
Phase 4
Recruiting
Miami, FL
18+
All Sexes
This study is evaluating whether a smoking cessation intervention is feasible and acceptable for Hispanic HIV patients.
Phase-Based Estimates
1
Effectiveness
2
Safety
Smart-T Mental Health+ And NRT
for Smoking, Cessation
Oklahoma City, OK
18+
All Sexes
Phase 2
Recruiting
1 Prior Treatment
Oklahoma City, OK
18+
All Sexes
Adults with serious mental illness (SMI) represent 5% of the United States population, yet account for 30% of all cigarettes smoked and are 2 to 3 times more likely to be dependent on nicotine compared with the general population. There are also significant disparities in quitting: 24% of lifetime smokers with SMI report not smoking within the past year compared with 52% of lifetime smokers without SMI. Two barriers partly explain the large disparity in smoking cessation rates between adults with and without SMI. First, there is a lack of high-quality, evidence-based interventions for smoking cessation in populations with SMI, which may be because adults with SMI are often excluded from clinical trials, despite evidence indicating that SMI is highly comorbid with smoking. Second, clinicians and staff within mental health settings generally do not have the resources or appropriate training to provide smoking cessation treatments to patients with SMI. Smartphone-based mobile health applications for smoking cessation could significantly improve cessation rates for adults with SMI. However, smoking cessation apps are underutilized by smokers with SMI partly because the apps are not designed for their unique needs. This study aims to conduct a pilot randomized controlled trial to evaluate the feasibility of an innovative, evidence-based smoking cessation app tailored for smokers with SMI. Seventy-five treatment-seeking smokers with SMI who will be referred from the Oklahoma Department of Mental Health and Substance Abuse Services (25 per group), a publicly funded outpatient psychiatry treatment program, will be randomly assigned to receive either (1) QuitGuide, a free smoking cessation app developed by the National Cancer Institute, (2) a smoking cessation app that tracks and automatically intervenes upon psychological distress during a quit attempt and delivers real-time intervention messages tailored to the current level of lapse risk and current lapse triggers (Smart-T Mental Health; STMH), or (3) the STMH app with additional messaging focused on increasing adherence to nicotine replacement medications (STMH+). All study conditions will be followed for 5 weeks (1-week pre-cessation and 4 weeks post-cessation), receive nicotine replacement therapy, and complete smartphone-based survey assessments using ecological momentary assessment procedures.
Phase-Based Estimates
1
Effectiveness
1
Safety
Automated Mobile Contingency Management (CM)
for Smoking, Cessation
Oklahoma City, OK
18+
All Sexes
Waitlist Available
Oklahoma City, OK
18+
All Sexes
This study is evaluating whether a mobile phone based approach to financial incentives may help individuals quit smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
N-Acetyl Cysteine
for Tobacco Dependence
San Francisco, CA
18+
All Sexes
Phase 4
Recruiting
San Francisco, CA
18+
All Sexes
This study is evaluating whether N-acetylcysteine may help reduce tobacco and cannabis use.
Phase-Based Estimates
1
Effectiveness
1
Safety
Wellness Intervention For Smokers With HIV
for HIV Infections
Seattle, WA
18+
All Sexes
Recruiting
Seattle, WA
18+
All Sexes
This study is evaluating whether a comprehensive wellness program will help smokers with HIV quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
QUIT
for Tobacco Dependence
Boston, MA
18+
All Sexes
Recruiting
1 Prior Treatment
Boston, MA
18+
All Sexes
This study is evaluating whether a specific type of therapy may help smokers living with HIV quit smoking.
Phase-Based Estimates
1
Effectiveness
2
Safety
Smart-T + NRT
for Smoking, Cessation
Oklahoma City, OK
18+
All Sexes
Phase 2 & 3
Recruiting
Oklahoma City, OK
18+
All Sexes
This study is evaluating whether a smartphone app can help individuals quit smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
Algorithm Treatment
for AIDS
Birmingham, AL
18+
All Sexes
Phase 4
Recruiting
Birmingham, AL
18+
All Sexes
This study is evaluating whether an algorithm can help primary care providers determine the best smoking cessation medications for their patients.
Phase-Based Estimates
1
Effectiveness
1
Safety
Internet-Based Intervention
for Tobacco Dependence
Houston, TX
18+
All Sexes
Waitlist Available
Houston, TX
18+
All Sexes
This study is evaluating whether a smartphone application may help smokers quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Multicomponent Behavioral Intervention
for Pediatric Obesity
Buffalo, NY
18 - 65
Female
Recruiting
Buffalo, NY
18 - 65
Female
The objective of this study is to test the effect of smoking cessation in pregnancy or in lactation on preventing rapid infant adiposity gain. Investigators propose a randomized, controlled experiment among smoking pregnant women from 1st prenatal care visit through 6 months of postpartum period. Two-phase randomization will be applied to separate the effects of smoking cessation in two different critical periods (i.e., pregnancy and lactation) on infant adiposity gain. Investigators will first randomly assign 40 smoking pregnant women into either the multicomponent intervention (N=30) or the education-only control group (N=10). The multicomponent intervention group will receive education and counseling, monitoring and feedback, contingent financial incentives, and family support, while the control group will receive education only. At the end of pregnancy, investigators will further randomize successful quitters (estimated N=20) from the multi-component intervention group into either the continuous multi-component intervention group in lactation (N=10) or the education-only control group (N=10). All women and their newborns will be followed from enrollment to 6 months postpartum. The key outcomes include maternal smoking abstinence confirmed by urine-cotinine and infant gain in weight-for-length z-score. Specific Aim 1 is to examine the effects of maternal smoking cessation intervention in pregnancy on infant gain in weight-for-length z-score from birth to 6 months. Specific Aim 2 is to examine the effect of maternal smoking abstinence intervention in lactation and infant post-weaning gain in weight-for-length z-score among the women who have successfully quit smoking in pregnancy.
Phase-Based Estimates
1
Effectiveness
2
Safety
Bupropion Hydrochloride Extended Release
for Anhedonia
Los Angeles, CA
18+
All Sexes
Phase 2
Waitlist Available
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a medication commonly used to treat depression may also help smokers quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Very Low Nicotine Content Cigarette
for Cigarette Smoking-Related Carcinoma
Houston, TX
18+
All Sexes
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether different levels of nicotine in cigarettes and e-cigarettes may help individuals quit smoking.
Phase-Based Estimates
3
Effectiveness
3
Safety
Nicotine Patch
for Hypersensitivity
Houston, TX
18+
All Sexes
Phase 4
Waitlist Available
Houston, TX
18+
All Sexes
The goal of this clinical research study is learn if varenicline or the nicotine patch can help people with different types of emotion and attention levels to quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Telephone Counseling Sessions
for Uterine Cervical Neoplasms
Oklahoma City, OK
18+
Female
Waitlist Available
Oklahoma City, OK
18+
Female
This study is evaluating whether a program called Motivation And Problem-Solving (MAPS) is more effective than the standard treatment to help people quit smoking.
Phase-Based Estimates
1
Effectiveness
1
Safety
Smoking Cessation Intervention
for Lung Cancer
Seattle, WA
Any Age
All Sexes
Recruiting
Seattle, WA
Any Age
All Sexes
This clinical trial develops a tailored screening and smoking cessation program for the lesbian, gay, bisexual, transgender (trans) and queer (LGBTQ) community of Seattle, Washington. A lung cancer screening program may help LGTBQ people who smoke overcome unique barriers that keep them from receiving preventive care, and constantly facing healthcare discrimination. Members of the LGBTQ community have historically smoked at higher rates than the general population and thus could benefit greatly from targeted efforts to improve lung cancer screening and smoking cessation implementation.
Phase-Based Estimates
1
Effectiveness
1
Safety
Active F8-coil Delivered RTMS
for Tobacco Dependence
Baltimore, MD
18 - 65
All Sexes
Waitlist Available
Baltimore, MD
18 - 65
All Sexes
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS and/or follow-ups.
Phase-Based Estimates
1
Effectiveness
1
Safety
Quitline Information With Reinforcement
for Smoking, Cessation
Cleveland, OH
18+
All Sexes
Waitlist Available
Cleveland, OH
18+
All Sexes
The primary objective of this pilot randomized controlled study is to raise awareness and use of an evidence-based tobacco cessation resource that is underutilized among smokers (the Ohio Tobacco Quitline), specifically targeting Cleveland-area residents who have experiences with food insecurity. The study will assess the feasibility and acceptability of conducting informational outreach on tobacco cessation resources in community settings in which there is a relatively high proportion of tobacco users (i.e., food pantries). The study will derive preliminary estimates regarding the effectiveness of tobacco cessation outreach, by assessing whether outreach activities result in changes in awareness/knowledge of the quitline and use/engagement of the quitline.
Phase-Based Estimates
2
Effectiveness
3
Safety
Cytisinicline
for Smoking, Cessation
DeLand, FL
18+
All Sexes
Phase 3
Recruiting
1 Prior Treatment
DeLand, FL
18+
All Sexes
This placebo-controlled Phase 3 study is being conducted at sites within the United States to evaluate 3 mg cytisinicline TID for treatment duration of 42 days/6 weeks as well as repeating that duration for a total of 84 days/12 weeks treatment.
Phase-Based Estimates
1
Effectiveness
1
Safety
John Hopkins Tobacco Treatment Clinic
for Tobacco Use Cessation
Baltimore, MD
18+
All Sexes
Phase < 1
Recruiting
Baltimore, MD
18+
All Sexes
This study is evaluating whether a brief intervention to help caregivers quit smoking during a child's hospitalization can help improve the child's health.
Phase-Based Estimates
1
Effectiveness
1
Safety
Clinician Communication Intervention
for Communication Research
Durham, NC
18+
All Sexes
Recruiting
Durham, NC
18+
All Sexes
The investigators propose to conduct a combined intervention that pairs SMS smoking cessation messages for patients with individualized training for OB clinicians to improve quit rates among pregnant smoking. The aim is to determine the effect of the intervention versus control on smoking cessation outcomes on patient smoking cessation. The investigators will recruit patients at their first OB visit who report smoking at Duke and Pitt. Patients in both the control and intervention arm will receive smoking cessation support messages throughout their pregnancy. OB clinicians in the intervention arm will receive tailored smoking cessation counseling training. Clinicians in both arms will receive a one-time 5 A lecture. The investigators will analyze smoking cessation outcomes and audio recordings. This is a minimal risk study.
Phase-Based Estimates
1
Effectiveness
1
Safety
Contingency Management - Increasing
for Smoking, Cessation
San Francisco, CA
18+
All Sexes
Recruiting
San Francisco, CA
18+
All Sexes
This study is evaluating whether a contingency management intervention can help homeless adults quit smoking.
Phase-Based Estimates
1
Effectiveness
2
Safety
EMB-01
for Tobacco Dependence
Raleigh, NC
18+
All Sexes
Phase 2 & 3
Recruiting
Raleigh, NC
18+
All Sexes
This study is evaluating whether a drug combination may help smokers quit.
Phase-Based Estimates
1
Effectiveness
1
Safety
Smoking Cessation + Quitline Linkage Text Messages
for Smoking, Cessation
Washington, United States
18+
All Sexes
Recruiting
Washington, United States
18+
All Sexes
Smoking rates among public housing residents are more than twice as high as in the general population. In August 2018, the U.S. Department of Housing and Urban Development (HUD) required all public housing in the U.S. to become smoke-free. While HUD recommended that Public Housing Authorities provide smoking cessations services, at present, the D.C. Housing Authority (DCHA) does not offer any cessation services to its residents. Low-income smokers face unique challenges to smoking cessation and require sustained support for smoking cessation. Digital interventions such as text messaging programs and quitline (QL) phone counseling are scalable, evidence-based interventions for smoking cessation that can provide support over an extended timeframe at low cost. The aim of this proposed research is to conduct a feasibility trial to assess the acceptability, levels of engagement, and preliminary efficacy of an integrated program that combines text-messaging for smoking cessation and text messages providing proactive linkage to the quitline compared to a single passive quitline text message referral among DCHA residents. The investigators hypothesize that the integrated program (combining text messages for smoking cessation and proactive quitline linkage) will yield significantly higher rates of quit attempts than passive quitline referral only.
Phase-Based Estimates
1
Effectiveness
1
Safety
Smoking Cessation Intervention (Actify App)
for Cigarette Smoking-Related Carcinoma
Seattle, WA
18+
All Sexes
Phase 1
Recruiting
Seattle, WA
18+
All Sexes
This study is evaluating whether a new smartphone application may help improve smoking cessation and mood management.
Phase-Based Estimates
1
Effectiveness
1
Safety