Genotype-Guided Smoking Cessation Therapy for Coronary Artery Disease
Trial Summary
What is the purpose of this trial?
This trial tests if using genetic information to guide smoking cessation treatment can help patients with coronary artery disease quit smoking more effectively. Patients will receive either nicotine replacement therapy or counseling based on their genetic test results.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment for smoking cessation in patients with coronary artery disease?
Research suggests that tailoring nicotine replacement therapy (NRT) based on genetic information can improve adherence and potentially increase the success rates of quitting smoking. Studies indicate that understanding genetic factors influencing nicotine metabolism and addiction can help personalize treatment, making it more effective for individuals.12345
Is genotype-guided smoking cessation therapy safe for people with coronary artery disease?
Research shows that nicotine replacement therapy (NRT), including nicotine patches, is generally safe for smokers hospitalized with coronary heart disease. A study found no difference in short-term outcomes like mortality or hospital readmission between those who used NRT and those who did not.26789
How is genotype-guided therapy with a nicotine patch unique for smoking cessation in coronary artery disease?
Eligibility Criteria
This trial is for adults with coronary artery disease undergoing cardiac catheterization or who have had a heart attack, and are active smokers. They must be able to consent, not incarcerated, stable post-heart attack without life-threatening complications, and women of child-bearing age should not be pregnant or breastfeeding.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Genotyping and Initial Treatment
Participants are genotyped and receive genotype-guided or standard smoking cessation therapy
Treatment
Participants continue with either pharmacologic therapy or counseling based on their assigned group
Follow-up
Participants are monitored for smoking cessation success and safety
Treatment Details
Interventions
- genotype-guided therapy
- Nicotine patch
- Smoking cessation counseling
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor