Although we did not find any evidence for a relationship between migraines and CVS, our study suggests that further research should focus more on the possibility for CVS to be a cause of migraine.
Ondansetron 0.3 mg intravenously administered before induction of anesthesia reduces the incidence of postoperative vomiting related to laparoscopic cholecystectomy without increasing analgesic use or duration of hospital stay.
Low-dose propranolol treatment improves symptoms in patients with refractory CVS. In a recent study, findings supports the notion that cyclic vomiting syndrome is a serotonin-mediated disorder.
Treatment guidelines for CVS must include both pharmacologic and nonpharmacologic therapy. Although most patients respond adequately to antiemetic agents alone, other measures are frequently needed. These include interdisciplinary management and surgical correction of gastrointestinal motility issues.
There is evidence that many medications are effective in treating CVS; however, these medications do not offer complete relief of symptoms, and therefore, other therapies may need to be explored. In particular, SSRIs were shown to be effective in relieving nausea and emesis. The current study suggests that SSRIs could be useful in treating CVS, especially when taken prior to the onset of the illness.
The cause of CVS remains unknown; however, there is evidence that it may be related to an underlying neurological disorder. The diagnosis of CVS requires careful exclusion of other conditions that can mimic its symptoms such as gastroesophageal reflux disease, migraine headaches, etc. For this reason, a thorough medical history, physical examination, and consideration of possible contributing factors (e.g., medication usage, diet) is recommended before making a diagnosis. The severity of symptoms and treatment response is strongly associated with psychiatric comorbidity. Patients should receive treatment for any coexisting psychiatric disorders if they have CVS. Aspects of management include appropriate preventive and symptomatic therapy, counseling, and support networks.
Although the exact cause of CVS is unknown, it occurs more often than once thought. In the U.S., women usually get CVS between the ages of 20 and 50 years old. A study published in 2015 identified four main risk factors for getting CVS; being overweight, having an underlying medical problem, smoking, and being female. There are three different categories of CVS. Cyclic vomiting syndrome (CVS) is defined as episodic weight loss, nausea, vomiting, and abdominal pain. Because there is no known cause, treatment options are limited. However, there are many treatments available. There are also numerous medications prescribed for CVS.
There appears to be no cure for CVS. However, from a functional perspective, there does appear to be some scope for managing the symptoms of CVS.
A family history of CVS is rare in this population. Data from a recent study do not support the hypothesis that CVS runs in families.
About 1.2 million Americans have CVS. Women are more likely than men to have CVS; however, the prevalence of CVS in women appears to be shrinking.
The diagnosis of CVS is difficult because of its wide spectrum of symptoms. In addition, many physicians are not familiar with CVS. Routine diagnostic tests may be useful if there is uncertainty about the diagnosis.
These data suggest that the use of anti-migraine medications during chronic migraine, even if used continuously, does not significantly reduce pain intensity nor disability; and do not appear to increase the risk of developing side effects. The lack of any reduction in pain intensity suggests that the reported adverse events were due to factors other than medication use.