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Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

Phase 2 & 3
Waitlist Available
Led By Marc E Mooney, Ph.D.
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Approved for 10 Other Conditions
All Individual Drugs Already Approved
No Placebo-Only Group

Summary

The purpose of this study is to compare the effects of bupropion + placebo to bupropion + naltrexone as treatments to help smokers quit.

Eligible Conditions
  • Tobacco Use Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: 2Experimental Treatment1 Intervention
Bupropion+Naltrexone
Group II: 1Active Control1 Intervention
Bupropion+Placebo

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,607 Previous Clinical Trials
3,329,695 Total Patients Enrolled
281 Trials studying Tobacco Use Disorder
49,117 Patients Enrolled for Tobacco Use Disorder
University of MinnesotaLead Sponsor
1,439 Previous Clinical Trials
1,621,838 Total Patients Enrolled
42 Trials studying Tobacco Use Disorder
7,940 Patients Enrolled for Tobacco Use Disorder
Marc E Mooney, Ph.D.Principal InvestigatorUniverisity of Minnesota
3 Previous Clinical Trials
171 Total Patients Enrolled
2 Trials studying Tobacco Use Disorder
128 Patients Enrolled for Tobacco Use Disorder
~6 spots leftby Jan 2026
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