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Behavioural Intervention

Phase 2a Non-Responders (A) for HIV/AIDS

N/A
Waitlist Available
Led By David Ledgerwood, PhD
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline: weekly through treatment phase 1; between 0 to 16 times during treatment phase 2 (non-responders meet 16 times; responders meet 0 or 6 times depending on group)
Awards & highlights

Summary

This trial will help researchers understand how to better help people with HIV/AIDS quit smoking.

Eligible Conditions
  • HIV/AIDS
  • Acquired Immunodeficiency Syndrome
  • Nicotine Addiction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline: weekly in treatment phase 1; between 0 to 16 times during treatment phase 2 (non-responders meet 16 times; responders meet 0 or 6 times depending on group); follow-up interviews (post-phase 1, post-phase 2, 6-months and 12-months)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline: weekly in treatment phase 1; between 0 to 16 times during treatment phase 2 (non-responders meet 16 times; responders meet 0 or 6 times depending on group); follow-up interviews (post-phase 1, post-phase 2, 6-months and 12-months) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Carbon Monoxide Results
Longest Duration of Continuous Abstinence
Seven-Day Point-Prevalence
+1 more

Trial Design

6Treatment groups
Experimental Treatment
Group I: Phase 2b: Responders (B)Experimental Treatment3 Interventions
Bupropion, continued monitoring and low intensity prize contingency management.
Group II: Phase 2b: Responders (A)Experimental Treatment2 Interventions
Bupropion, no additional treatment.
Group III: Phase 2a: Non-Responders (B)Experimental Treatment3 Interventions
Bupropion, monitored support to quit smoking, prize contingency management for abstinence.
Group IV: Phase 2a Non-Responders (A)Experimental Treatment3 Interventions
Bupropion, continued counseling, monitored support to quit smoking.
Group V: Phase 1: Standard of Care (B)Experimental Treatment3 Interventions
Brief counseling, bupropion, and brief high-magnitude prize contingency management.
Group VI: Phase 1: Standard of Care (A)Experimental Treatment2 Interventions
Brief counseling and bupropion
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupropion
FDA approved
Brief Counseling
2021
N/A
~1230
No additional treatment
2006
N/A
~50

Find a Location

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
312 Previous Clinical Trials
109,131 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,503 Previous Clinical Trials
2,625,418 Total Patients Enrolled
David Ledgerwood, PhDPrincipal InvestigatorWayne State University
1 Previous Clinical Trials
150 Total Patients Enrolled
~14 spots leftby Sep 2025
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