Cognitive Behavioral Therapy for Smoking Cessation in HIV/AIDS
What You Need to Know Before You Apply
What is the purpose of this trial?
Smokers living with HIV represent a major health disparity population in the United States and the world more generally. Major contributing factors to the maintenance and relapse of smoking among smokers living with HIV include increased exposure to multiple stressors associated with HIV, which often exacerbates anxiety/depression. In a previous project, the feasibility, acceptability, and initial efficacy of a 9-session, cognitive-behavioral-based intervention to address smoking cessation by reducing anxiety and depression via specific emotional vulnerabilities (anxiety sensitivity, distress tolerance, and anhedonia) was tested against an enhanced standard of care in a pilot randomized controlled trial (NCT01393301). It was found that when compared to a brief enhanced treatment as usual control, patients in the intervention achieved higher short-term and long-term smoking abstinence rates. In this project, the investigators seek to test this same intervention in a fully powered, 3-arm efficacy/effectiveness trial. The goal of this study is to randomize 180 smokers across three sites to test the efficacy/effectiveness of the intervention at increasing point prevalence abstinence by reducing anxiety and depression at a 1-month follow-up (the end of treatment timepoint/ approximately 1-month post quit day) and a 6-month follow-up (approximately 6-months post quit day).
Who Is on the Research Team?
Jasper Smits, PhD
Principal Investigator
University of Texas at Austin
Michael Zvolensky, PhD
Principal Investigator
University of Houston
Are You a Good Fit for This Trial?
This trial is for HIV-positive individuals aged 18-79 who smoke daily and are motivated to quit. They must understand English well enough to give informed consent. People using other tobacco products, undergoing current smoking cessation treatment, or with untreated/unstable psychiatric disorders can't participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a 9-session, cognitive-behavioral therapy-based intervention for smoking cessation and anxiety/depression management
Short-Term Follow-up
Participants are monitored for smoking abstinence and changes in anxiety/depression at 1-month post quit day
Long-Term Follow-up
Participants are monitored for smoking abstinence and changes in anxiety/depression at 6-months post quit day
What Are the Treatments Tested in This Trial?
Interventions
- QUIT
- Time-Matched Control (TM)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
Southern Methodist University
Collaborator
The Fenway Institute
Collaborator
University of Texas at Austin
Collaborator
University of Houston
Collaborator
Baylor College of Medicine
Collaborator