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Cognitive Behavioral Therapy for Smoking Cessation in HIV/AIDS

Led By Jasper Smits, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-79 years old
18-79 years old
Screening 3 weeks
Treatment Varies
Follow Up time frame: 6-month follow-up (approximately 6-months post quit date)
Awards & highlights
No Placebo-Only Group

Study Summary

This trial is testing a cognitive-behavioral-based intervention to help smokers living with HIV quit smoking by reducing anxiety and depression.

Who is the study for?
This trial is for HIV-positive individuals aged 18-79 who smoke daily and are motivated to quit. They must understand English well enough to give informed consent. People using other tobacco products, undergoing current smoking cessation treatment, or with untreated/unstable psychiatric disorders can't participate.Check my eligibility
What is being tested?
The study tests a cognitive-behavioral-based intervention called QUIT against a Time-Matched Control (TM) to help smokers living with HIV quit by reducing anxiety and depression. It's a fully powered trial aiming to see if the intervention increases abstinence from smoking at 1-month and 6-month follow-ups.See study design
What are the potential side effects?
While specific side effects are not listed for this behavioral intervention, participants may experience discomfort discussing personal issues or stress related to quitting smoking during the sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am between 18 and 79 years old.
I am between 18 and 79 years old.
I am willing and able to sign a consent form.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time frame: 6-month follow-up (approximately 6-months post quit date)
This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame: 6-month follow-up (approximately 6-months post quit date) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Long-Term Point Prevalence Smoking Abstinence
Short-Term Point Prevalence Smoking Abstinence

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: QUIT Treatment for Smoking Cessation and Distress ToleranceExperimental Treatment1 Intervention
Participants in this intervention arm will receive a Cognitive-Behavioral therapy-based intervention for smoking cessation in people living with HIV.
Group II: Time and Intensity-Match ControlActive Control1 Intervention
Participants in this control arm will receive an intervention matched in time and intensity with the experimental arm.
Group III: Standard of CareActive Control1 Intervention
At each clinic, routine assessment of smoking status occurs at least annually for patients receiving care, but prescription for pharmacotherapy for smoking cessation and referral for behavioral smoking cessation services are rare. Patients will receive the standard of care at the clinic they attend. SOC patients will also attend the first session that participants in the other sessions receive (pre-randomization), will come to the clinic for assessment only during the weeks lining up with sessions 6-10 for the other conditions, and receive the transdermal nicotine patch for 8 weeks.

Find a Location

Who is running the clinical trial?

Southern Methodist UniversityOTHER
33 Previous Clinical Trials
5,513 Total Patients Enrolled
Massachusetts General HospitalLead Sponsor
2,907 Previous Clinical Trials
13,186,023 Total Patients Enrolled
The Fenway InstituteOTHER
14 Previous Clinical Trials
2,491 Total Patients Enrolled

Media Library

QUIT Clinical Trial Eligibility Overview. Trial Name: NCT03904186 — N/A
Smoking/Cigarette Smoking Research Study Groups: Time and Intensity-Match Control, QUIT Treatment for Smoking Cessation and Distress Tolerance, Standard of Care
Smoking/Cigarette Smoking Clinical Trial 2023: QUIT Highlights & Side Effects. Trial Name: NCT03904186 — N/A
QUIT 2023 Treatment Timeline for Medical Study. Trial Name: NCT03904186 — N/A
Smoking/Cigarette Smoking Patient Testimony for trial: Trial Name: NCT03904186 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would I qualify to contribute to this clinical research?

"The parameters to be admitted into this trial include being aged between 18 and 79, plus a history of smoking cigarettes. In total, 360 people will be enrolled in the study."

Answered by AI

What is the current patient count for this experimental treatment?

"Affirmative. The trial's current status is recruiting according to clinicaltrials.gov, with the initial posting on December 19th 2019 and most recent editing occurring February 1st 2021. At 3 different sites, 360 individuals are sought for enrollment in this research project."

Answered by AI

Does the clinical trial permit geriatric individuals to participate?

"According to the trial's eligibility criteria, patients must be between 18 and 79 years old in order to participate. For those outside of this age range, there are 436 trials for young participants and 1893 studies available for elderly individuals."

Answered by AI

Is the research team currently recruiting participants for this experiment?

"According to the clinicaltrials.gov records, this medical study is actively seeking participants. The initial posting date was December 19th 2019 and it has since been modified on February 1st 2021."

Answered by AI

Who else is applying?

What state do they live in?
Rhode Island
How old are they?
18 - 65
What site did they apply to?
Fenway Community Health
Massachusetts General Hospital
Thomas Street Health Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?

Why did patients apply to this trial?

I'm interested in quitting smoking. I tried to quit on my own without success.
PatientReceived 1 prior treatment
Maybe in hopes to find a cure to my tobacco addiction. I really need to stop smoking for my health and grandbabies.
PatientReceived 2+ prior treatments
I believe I need to do this trial, to help and to quit smoking.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How long do screening visits take? What does it entail in its entirety ? How long does the study take to complete?
PatientReceived 1 prior treatment

How responsive is this trial?

Typically responds via
Most responsive sites:
  1. Massachusetts General Hospital: < 24 hours
Average response time
  • < 1 Day
~70 spots leftby Feb 2025