Concussion Clinical Trials
Here are the 6 most popular medical studies for concussion
Neck Muscle Strengthening for Concussion Risk Reduction
This trial is studying whether neck-strengthening exercises can help reduce the risk of sport-related concussion. Male and female soccer athletes aged 13-19 will do the exercises for 12 weeks and be assessed throughout for changes.
Hormone Therapy
Melatonin for Traumatic Brain Injury
This trial will test if giving melatonin to children after a concussion can help them sleep better, reduce depression, lower the risk of long-lasting concussion symptoms, and speed up their recovery.
Non-invasive Brain Stimulation
rTMS for AUD+mTBI
This trial is testing whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help reduce alcohol craving in veterans with mild traumatic brain injury and/or post-traumatic stress disorder.
Popular filter options for concussion trials
Post-Concussion Syndrome Clinical Trials
View 37 Post-Concussion Syndrome medical studies.
Procedure
rTMS for Post-Concussion Syndrome
This trial studies how rTMS, a non-invasive brain stimulation technique, can help reduce chronic headaches from mild traumatic brain injury (mTBI). It aims to improve post-concussion symptoms & reduce costs of delayed recovery.
Procedure
Hyperbaric Oxygen for Traumatic Brain Injury
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
PCS Clinical Trials
View 26 PCS medical studies.
Procedure
rTMS for Post-Concussion Syndrome
This trial studies how rTMS, a non-invasive brain stimulation technique, can help reduce chronic headaches from mild traumatic brain injury (mTBI). It aims to improve post-concussion symptoms & reduce costs of delayed recovery.
Procedure
Hyperbaric Oxygen for Traumatic Brain Injury
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
Hormone Therapy
Melatonin for Concussion
PURPOSE: The long-term goal of this line of research is to develop rational, biologically based evidence for the treatment of post-concussion syndrome (PCS) in children. The objective of this application is to examine the effect of melatonin on the symptoms of PCS and its neurobiology using integrated neurodiagnostic techniques in children. OVERVIEW: PCS is a constellation of clinical symptoms including physical (i.e. headaches), cognitive (i.e. memory), and behavioral disturbances. PCS is associated with significant morbidity in the child and his/her family), and yet there are no evidence-based medical treatments available. This suggests an urgent need to develop novel treatment options to improve outcomes for children suffering from PCS. Melatonin has several relevant mechanisms of action, and neuroprotective effects. Recent research suggests that the explanations for persistent PCS symptoms may be due to alterations in neurotransmissions and neuronal circuitry, particularly involving the dorsolateral prefrontal cortex (DLPFC). Investigators have two specific aims: To determine if treatment with melatonin improves PCS in children following mild traumatic brain injury. Hypothesis: treatment of mTBI children with PCS with 3mg or 10mg of oral melatonin for 28 days will result in a decrease in PCS symptoms as compared with placebo. Effects will be dose-dependent and may be independent of sleep effects. Methods: A randomized double blind, placebo controlled trial (RCT); Outcome measure is a PCS symptom questionnaire. A subsequent RCT will then be performed using the optimal melatonin dose at a second centre. To understand the neurophysiological mechanisms of paediatric PCS and assess any resultant effects of treatment with melatonin. Methods: A case-controlled study within the RCT, using functional MRI and Transcranial Magnetic Stimulation to investigate the neurophysiological properties of paediatric mTBI before and after treatment; Treatment groups from the RCT will be compared with two control groups: i) normal controls and ii) asymptomatic mTBI children. SIGNIFICANCE: This study has the potential to 1) provide a safe and effective treatment for PCS and 2) will provide valuable information about the neurophysiological properties of the brain associated with PCS following mTBI in children and how these change with symptom resolution.
Behavioral Intervention
Sub-symptom aerobic exercise for Concussion
Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency department will experience symptoms that last longer than a month. Research has demonstrated that exercise below the threshold that results in increases in symptoms, beyond those experienced at rest, (sub-symptom threshold aerobic exercise) may be beneficial in recovery. However, the optimal amount and intensity of aerobic exercise for an individual to experience the most beneficial outcomes is currently unknown. Unfortunately there are limited Randomized Controlled Trials (RCT's) evaluating the benefits of aerobic exercise in a youth population. The current evidence includes studies with relatively small sample sizes, unreliable measurements of physical activity (self-report), and inherent biases through inadequate blinding. There is a need to develop and validate evidence-informed interventions as a means of treatment for limiting time loss from sport, and school in adolescents who experience persistent symptoms of sports related concussion beyond 10 days.
Concussion Clinical Trials With No Placebo
View 98 concussion medical studies that do not have a placebo group.
Behavioural Intervention
Portable Mixed Reality-based Platform for Cognitive Disorders
This trial aims to test whether a new rehabilitation method called Praxis, which uses wearable sensors and a virtual reality environment, can help military service members with mild Traumatic Brain Injury (mTBI)
View More Concussion Trials
See another 73 medical studies focused on concussion.
Frequently Asked Questions
Introduction to concussion
What are the top hospitals conducting concussion research?
When it comes to advancing our understanding of concussions, several top hospitals across the United States are leading the way. In Pittsburgh, Pennsylvania, the University of Pittsburgh is at the forefront with three active concussion trials and a total of four trials conducted thus far. Since recording their first concussion trial in 2017, this hospital has been dedicated to investigating ways to improve diagnosis and treatment for this common brain injury. In Hines, Illinois, Edward Hines Jr. VA Hospital is also contributing significantly with three ongoing concussion trials and a history of four previous studies since their inaugural trial in 2019.
Meanwhile, Mayo Clinic in Rochester, Minnesota is making strides as well with its current involvement in three active concussion trials and two completed studies overall since initiating research efforts on this condition in 2019. On the West Coast at Naval Medical Center San Diego in California, researchers have been diligently working on concussions since their first recorded trial back in 2013. With two active clinical trials and a total of four conducted experiments in their arsenal, they continue to make valuable contributions towards improving patient outcomes.
Further expanding our knowledge on concussions is taking place at Milwaukee's Medical College of Wisconsin where researchers are actively engaged with two ongoing clinical trials while building upon four prior investigations dating back to 2015.
Across these esteemed institutions scattered throughout the country- from Pittsburgh to Hines; Rochester to San Diego; Milwaukee- medical professionals are focused on identifying better methods for diagnosing and treating concussions effectively.With every study they undertake or complete,it brings us closer towards enhancing care provision for those affected by these head injuries that can potentially impact lives both inside military services & civilian community.This collective effort demonstrates commitment towards improving quality-of-life post-concussion not only among service members but also athletes,falls victims,and anyone who may have experienced such incidents
Which are the best cities for concussion clinical trials?
When it comes to concussion clinical trials, several cities are at the forefront of research and development. Vancouver, British Columbia leads with 14 active trials exploring treatments like Cognitive Behavioural Therapy (CBT), Guideline implementation tools, and Graded Exposure Therapy. Calgary, Alberta follows closely behind with 10 ongoing studies focused on interventions such as rTMS, Symptom-specific Headache Treatment, and Melatonin 10mg. Toronto, Ontario also contributes significantly with 6 active trials investigating approaches like Graded Exposure Therapy and Newly designed computer monitors. Additionally, Seattle in Washington state and Pittsburgh in Pennsylvania each have 5 active trials examining various treatment options for concussions. These cities provide valuable opportunities for individuals affected by concussions to participate in groundbreaking clinical research aimed at improving outcomes and enhancing care strategies.
Which are the top treatments for concussion being explored in clinical trials?
Clinical trials are currently exploring several promising treatments for concussions. Among these, HS-1000 recording is leading the way with two active trials and a total of two concussion trials since its debut in 2015. Another noteworthy contender is tdcs in Youth with mild traumatic brain injury, which has embarked on one active trial and stands as the sole concussion trial listed thus far since its introduction in 2023. These innovative treatments offer hope for improved management and recovery from concussions, paving the way towards better outcomes for individuals affected by this condition.
What are the most recent clinical trials for concussion?
Exciting progress is being made in the field of concussion research, with recent clinical trials exploring novel approaches to treatment. One such trial focuses on active iTBS, a non-invasive brain stimulation technique that shows potential for aiding concussion recovery. Another study investigates active left frontal HD-tdcs, which targets specific areas of the brain to mitigate symptoms associated with concussions. Additionally, high-dose exercise has emerged as a promising intervention for individuals recovering from concussions. These advancements provide hope for improving outcomes and quality of life for those affected by this common injury.
What concussion clinical trials were recently completed?
Recent advancements in concussion research have seen the completion of several noteworthy clinical trials. In October 2020, a trial led by Michael Rippee, MD, investigated the potential benefits of Ghrelin (OXE-103) for individuals with concussions. Another significant study conducted by The University of Texas Health Science Center at San Antonio concluded in February 2019 and examined the use of Quetiapine Fumarate as a potential treatment for concussions. These completed trials represent important contributions to our understanding and management of this complex neurological condition.