Bupivacaine Injection for Post-Traumatic Headache
What You Need to Know Before You Apply
What is the purpose of this trial?
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is Bupivacaine safe for use in humans?
Bupivacaine, used under various names like Marcaine and Exparel, has been shown to be generally safe in humans when used as directed, with minimal side effects. Studies have shown it to be safe in obstetrical analgesia and for postsurgical pain relief, with limited side effects when proper dosing guidelines are followed.12345
How is the drug Bupivacaine Injection unique for treating post-traumatic headache?
What data supports the effectiveness of the drug Bupivacaine Injection for treating post-traumatic headache?
Research shows that liposomal bupivacaine, a form of bupivacaine, is effective in reducing postoperative pain and opioid use in surgeries, suggesting it may help manage pain in other conditions too. Additionally, bupivacaine is widely used in obstetrics for pain relief with minimal side effects, indicating its potential for safe and effective pain management.135710
Are You a Good Fit for This Trial?
This trial is for U.S. Military Veterans within the VA Connecticut Healthcare System who suffer from chronic post-traumatic headaches, occurring at least twice a week. Participants must have had an MRI brain scan recently and their medical records should not indicate another source for their headaches. Pregnant individuals or those with certain allergies, heart conditions related to amide anesthetics, or skull defects cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive different concentrations of bupivacaine for greater occipital nerve blockade, injected one week apart
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Bupivacaine Injection
Bupivacaine Injection is already approved in United States, European Union for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
National Headache Foundation
Collaborator
VA Connecticut Healthcare System
Collaborator