Graded Exposure Therapy for Brain Injuries, Traumatic

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Sunnybrooke Traumatic Brain Injury Clinic, Toronto, Canada
Brain Injuries, Traumatic+5 More
Graded Exposure Therapy - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will assess whether graded exposure therapy is effective in reducing fear avoidance behavior in people with concussion. Graded Exposure Therapy, which has been previously approved by the FDA for a different condition, is being used to treat Brain Injuries, Traumatic. No patients in this trial will receive a placebo.

Eligible Conditions

  • Brain Injuries, Traumatic
  • Mild Traumatic Brain Injury (MTBI)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Brain Injuries, Traumatic

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 3 months

3 months
Fear Avoidance Behaviour after Traumatic Brain Injury Questionnaire (FAB-TBI): Change
Illness Perception Questionnaire-Revised (IPQ-R): Change
Rivermead Post Concussion Symptoms Questionnaire (RPQ): Change
World Health Organization Disability Assessment Schedule (WHODAS) 2.0 12-item: interviewer version: Change.

Trial Safety

Safety Progress

1 of 3

Other trials for Brain Injuries, Traumatic

Trial Design

3 Treatment Groups

Arm 3: Enhanced usual care
1 of 3
Arm 2: Prescribed Aerobic Exercise
1 of 3
Arm 1: Graded Exposure Therapy
1 of 3
Active Control
Experimental Treatment

220 Total Participants · 3 Treatment Groups

Primary Treatment: Graded Exposure Therapy · No Placebo Group · N/A

Arm 1: Graded Exposure Therapy
Behavioral
Experimental Group · 1 Intervention: Graded Exposure Therapy · Intervention Types: Behavioral
Arm 3: Enhanced usual care
Other
ActiveComparator Group · 1 Intervention: Enhanced usual care · Intervention Types: Other
Arm 2: Prescribed Aerobic Exercise
Behavioral
ActiveComparator Group · 1 Intervention: Prescribed aerobic exercise · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
Closest Location: Sunnybrooke Traumatic Brain Injury Clinic · Toronto, Canada
Photo of Toronto 1Photo of Toronto 2Photo of Toronto 3
N/AFirst Recorded Clinical Trial
1 TrialsResearching Brain Injuries, Traumatic
0 CompletedClinical Trials

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,296 Previous Clinical Trials
1,271,087 Total Patients Enrolled
10 Trials studying Brain Injuries, Traumatic
862 Patients Enrolled for Brain Injuries, Traumatic
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,216 Previous Clinical Trials
24,391,794 Total Patients Enrolled
14 Trials studying Brain Injuries, Traumatic
10,200 Patients Enrolled for Brain Injuries, Traumatic
Noah Silverberg, PhDPrincipal InvestigatorUniversity of British Columbia
4 Previous Clinical Trials
254 Total Patients Enrolled
3 Trials studying Brain Injuries, Traumatic
104 Patients Enrolled for Brain Injuries, Traumatic

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have sustained a concussion in the past 12 months.
You have access to a computer, tablet, or smartphone with internet capability.
You have 3 or more moderate-severe symptoms on the Rivermead Postconcussion Symptom Questionnaire.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.