Traumatic Brain Injury Clinical Trials 2022

Browse 93 Traumatic Brain Injury Medical Studies Across 74 Cities

7 Phase 3 Trial · 162 Traumatic Brain Injury Clinics

Reviewed by Michael Gill, B. Sc.
Photo of San Antonio 1
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

In-Personfor Brain Concussion

San Antonio, TX
18+
All Sexes
Throughout the course of the wars in Iraq and Afghanistan, more than 250,000 service members sustained traumatic brain injuries, mostly characterized as mild traumatic brain injuries (mTBI) or concussions. While most with mTBI recover over days to weeks, a significant percentage continue to experience post-concussive symptoms such as headaches, cognitive difficulties, and dizziness for months to years. As a result, treatment of post-concussive symptoms after mTBI is of significant importance in the Department of Defense and Veterans healthcare systems. Several studies have shown that cognitive rehabilitation can be effective for individuals with mTBI, including Service Members and Veterans with post concussive symptoms. Cognitive rehabilitation is a type of treatment in which patients work with a therapist to improve everyday memory and thinking skills and develop strategies to reduce the impact of cognitive difficulties in their everyday lives. While these treatments have great potential benefits, protocols studied to date are time intensive, requiring up to 60 hours of treatment. These time demands are impractical for many Service Members and Veterans, and place a time-burden on clinics providing the treatment. The current study proposes to identify key ingredients of an evidence-based cognitive rehabilitation protocol to develop a streamlined version that is feasible and acceptable to Service Members and Veterans. This briefer protocol will increase the number of Service Members and Veterans who can access treatment. To accomplish this goal the investigators will first spend six months analyzing manualized treatments from a successful cognitive rehabilitation intervention developed for Service Members. The investigators will analyze manuals using a framework developed to identify active ingredients in rehabilitation. Based on those results the investigators will develop a manualized streamlined treatment protocol, which the investigators will deliver to 25 Service Members and 50 Veterans over 18 months in person or via telehealth. The investigators will determine feasibility and acceptability of this intervention, and collect preliminary efficacy data. The project addresses access to therapy services and enhanced treatment compliance, a key barrier to participation in cognitive rehabilitation by Veterans and Service Members with TBI. Additionally, although this study focuses on Service Members and Veterans with mTBI, the investigators expect that this streamlined intervention can also be translated to civilian populations with mTBI.
Recruiting
Has No Placebo
Photo of oh university of cincinnati 1
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

CG-Wellfor Brain

Cincinnati, OH
18+
All Sexes
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive symptoms. Caregivers frequently report minimal support or training to prepare them for their new role. Periods of care transitions, such as ICU discharge, are most difficult. The majority (93%) of previously developed caregiver and caregiver/survivor dyad interventions after msTBI focus on providing information or practical skills to either survivors, or to long-term caregivers (>6 months post injury), rather than education, support, and skill-building that the new caregiver may use proactively that will benefit the dyad acutely after injury. The Aims of this proposal are to: (1) Determine feasibility, satisfaction, and data trends of CG-Well; and (2) Understand how baseline psychosocial risk factors affect response to CG-Well compared to an Information, Support, and Referral control group. To accomplish this, I will first enroll 6-10 caregivers and tailor CG-well until each finds the intervention acceptable, appropriate, and feasible. I will then enroll 100 (50/group) dyads and determine satisfaction ratings, recruitment, retention, and treatment fidelity of CG-Well. Additionally, I will determine if caregivers report reductions in depressive symptoms and improvements in life changes as a result of improvements in task difficulty and threat appraisal in CG-Well compared to ISR at six months. Information obtained in Aims 1 and 2 will be used to plan a larger Phase III trial of CG-Well. Completing these Aims and the training plan will improve outcomes of caregivers and downstream outcomes of survivors of msTBI, and provide me with the skillset necessary to become an independent researcher who can develop and test high-impact, high-fidelity, sustainable interventions.
Recruiting
Behavior
25 Traumatic Brain Injury Clinical Trials Near Me
Minneapolis, MN
Houston, TX
Villanova, PA
San Antonio, TX
More Trial Locations
An interactive map to display trial locations for Hennepin County Medical Center, The University of Texas Health Science Center at Houston, Villanova University, Brooke Army Medical Center, and 30 more locations.
Most Popular References for Traumatic Brain Injury Clinical Trials
Frequency
Citation
Top Hospitals for Traumatic Brain Injury Clinical Trials
Location
Active Traumatic Brain Injury Clinical Trials
All Time Trials for Traumatic Brain Injury
First Recorded Traumatic Brain Injury Trial
Trials
The University of Texas Health Science Center at Houston, Houston, Texas
2
2
2021
Top Treatments for Traumatic Brain Injury Clinical Trials
Treatment Name
Active Traumatic Brain Injury Clinical Trials
All Time Trials for Traumatic Brain Injury
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Trials
Manual Lymphatic Drainage (MLD)
1
1
2021
Top Cities for Traumatic Brain Injury Clinical Trials
City
Active Traumatic Brain Injury Clinical Trials
Top Active Site for Traumatic Brain Injury Clinical Trials
Trial List
Minneapolis, Minnesota
8
Hennepin County Medical Center
Houston, Texas
7
The University of Texas Health Science Center at Houston
Phase 3 Traumatic Brain Injury Clinical Trials
Pediatric Traumatic Brain Injury Clinical Trials
Senior Friendly Traumatic Brain Injury Clinical Trials

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 13th, 2021

Last Reviewed: August 7th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.