Popular Trials
Behavioural Intervention
Bright Light Therapy for TBI
This trial aims to improve sleep quality for veterans with TBI as a means to reduce pain and improve quality of life and functional outcome measures. The investigators predict that the proposed intervention, morning bright light therapy, if found effective, will be rapidly deployable and highly accepted by Veterans with TBI.
Behavioral Intervention
Complex Balance Tasks for Traumatic Brain Injury
This trial will explore how a moderate TBI in early/middle adulthood can affect brain health/function in older age, with the goal of designing interventions to preserve brain health in TBI survivors.
Selective Serotonin Reuptake Inhibitor
Citalopram for Depression
The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with recent traumatic brain injury (TBI).
Popular Filters
Trials for Concussion Patients
Behavioral Intervention
Narrative Discourse Treatment for Traumatic Brain Injury
This trial tests a new therapy to help Veterans with TBI improve their storytelling skills. The therapy aims to make their stories better organized and more meaningful, which can help them communicate better in daily life. Storytelling interventions are increasingly being proposed as a tool for rehabilitation after Traumatic Brain Injury (TBI).
Behavioral Intervention
RTM vs PE for PTSD
This trial is testing a novel treatment for PTSD called reconsolidation of memories (RTM) versus the current best treatment, prolonged exposure (PE). The goal is to see if RTM is better at reducing symptoms, improving cognitive function, and achieving remission.
Trials for TBI Patients
Behavioral Intervention
Narrative Discourse Treatment for Traumatic Brain Injury
This trial tests a new therapy to help Veterans with TBI improve their storytelling skills. The therapy aims to make their stories better organized and more meaningful, which can help them communicate better in daily life. Storytelling interventions are increasingly being proposed as a tool for rehabilitation after Traumatic Brain Injury (TBI).
Behavioral Intervention
RTM vs PE for PTSD
This trial is testing a novel treatment for PTSD called reconsolidation of memories (RTM) versus the current best treatment, prolonged exposure (PE). The goal is to see if RTM is better at reducing symptoms, improving cognitive function, and achieving remission.
Phase 3 Trials
Behavioral Intervention
RTM vs PE for PTSD
This trial is testing a novel treatment for PTSD called reconsolidation of memories (RTM) versus the current best treatment, prolonged exposure (PE). The goal is to see if RTM is better at reducing symptoms, improving cognitive function, and achieving remission.
Procedure
Hyperbaric Oxygen for Traumatic Brain Injury
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
Growth Hormone Replacement Therapy
Somatropin for Growth Hormone Deficiency and Concussion
This trial is testing if giving extra growth hormone can help improve the quality of life for adults who have low growth hormone levels and mild brain injuries. Growth hormone treatment has been shown to improve quality of life in adults with growth hormone deficiency.
Antipsychotic
Quetiapine for Post-Concussion Syndrome
This trial will compare the effectiveness of quetiapine alone to the usual medication management for veterans with mild traumatic brain injury and posttraumatic stress disorder who are undergoing rehabilitation therapy.
Trials With No Placebo
Behavioral Intervention
Narrative Discourse Treatment for Traumatic Brain Injury
This trial tests a new therapy to help Veterans with TBI improve their storytelling skills. The therapy aims to make their stories better organized and more meaningful, which can help them communicate better in daily life. Storytelling interventions are increasingly being proposed as a tool for rehabilitation after Traumatic Brain Injury (TBI).
Behavioral Intervention
RTM vs PE for PTSD
This trial is testing a novel treatment for PTSD called reconsolidation of memories (RTM) versus the current best treatment, prolonged exposure (PE). The goal is to see if RTM is better at reducing symptoms, improving cognitive function, and achieving remission.
Device
ITPR for Traumatic Brain Injury
This trial is for patients who have a functioning intracranial pressure-monitoring device and are either sedated, intubated, and mechanically ventilated, or are scheduled to undergo an operation or interventional neuroradiological procedure. The ITPR will be inserted in the ventilator circuit and activated to provide either -5 mm Hg or -9 mm Hg endotracheal rube pressure. The effect of the ITPR on intracranial pressure, cerebral perfusion pressure, and secondary indicators of cardiac performance will be examined.
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Frequently Asked Questions
Introduction to traumatic brain injury
What are the top hospitals conducting traumatic brain injury research?
Traumatic brain injury (TBI) is a complex condition that requires innovative research and specialized care. In the quest for advancements, hospitals worldwide are stepping up to lead the charge. Vancouver General Hospital, nestled in the beautiful city of Vancouver, has recognized the urgency in addressing TBI with three ongoing clinical trials aimed at improving outcomes for those affected by this devastating injury. Similarly committed, The Ottawa Hospital in Canada's capital city is conducting three active TBI trials of its own. Across the border in Charlottesville, Virginia, researchers at the University of Virginia are dedicated to finding solutions through two ongoing clinical trials targeting TBI patients. Meanwhile, NYU Langone Health in New york City and the University of Alabama at Birmingham have likewise prioritized this area of study with two active TBI trials each.
Unlike some other medical conditions where extensive historical research may already exist, it is worth mentioning that these five prominent hospitals have not yet conducted any previous clinical trials specifically focused on traumatic brain injuries. This emphasizes both the critical need for further investigation and their determination to make groundbreaking discoveries.
The global efforts being made by these institutions reflect a collective dedication to unraveling the mysteries surrounding traumatic brain injury and ultimately enhancing patient outcomes. Through their interdisciplinary approach and cutting-edge research initiatives, they provide hope for individuals suffering from this life-altering condition while inspiring progress within a field ripe with potential breakthroughs.
Which are the best cities for traumatic brain injury clinical trials?
When it comes to clinical trials for traumatic brain injury, several cities have emerged as leaders in research and development. Minneapolis, Minnesota boasts 9 active trials focusing on interventions like the Ketogenic Diet, Anodal Transcranial Direct Current Stimulation, and Theta Burst Stimulation. Toronto, Ontario follows closely behind with 8 ongoing studies exploring treatments such as Red Blood Cells Transfusion, Anticoagulant therapy, and Standard of Care plus Education. Houston, Texas is also a hub for TBI clinical trials with 7 active studies investigating approaches like ACT on Life therapy and pharmaceutical interventions like Donepezil. These cities provide individuals affected by traumatic brain injuries access to cutting-edge research that may lead to improved treatment options and better outcomes.
Which are the top treatments for traumatic brain injury being explored in clinical trials?
Clinical trials are paving the way for advancements in traumatic brain injury (TBI) treatment. Among the top contenders being explored in these trials are:
- NeuroSTAT: A drug designed to reduce brain swelling and improve outcomes.
- ApoE4-targeted immunotherapy: Focusing on targeting a genetic variant associated with increased risk of poor TBI recovery.
- Erythropoietin (EPO): Investigating its potential to promote neuroprotection and aid in TBI recovery. These treatments hold promise in improving outcomes and providing hope for individuals affected by this debilitating condition.
What are the most recent clinical trials for traumatic brain injury?
Promising developments are underway in the realm of traumatic brain injury (TBI) research, with recent clinical trials offering newfound hope for patients. One notable trial focuses on active iTBS, a non-invasive stimulation technique that shows potential in improving TBI outcomes. Another study investigates the efficacy of Atorvastatin calcium as an intervention for TBI patients, aiming to explore its benefits further. In addition, Group A and Allopregnanolone have emerged as significant candidates for advancing TBI treatment options. Lastly, KF-mSMT Plus Aerobic Exercise Training presents a novel approach to enhance recovery from this debilitating condition. With these groundbreaking trials shedding light on innovative methods and therapies, there is renewed optimism surrounding TBI management and patient care moving forward.
What traumatic brain injury clinical trials were recently completed?
Several clinical trials focusing on traumatic brain injury have recently concluded, bringing new insights and potential treatments to light. In September 2021, a trial investigating the efficacy of NeuroSTAT therapy was successfully completed by NeuroVive Pharmaceutical AB. Another significant milestone occurred in February 2021 when the University of Pittsburgh Medical Center wrapped up their study exploring the use of progesterone hormone for treating traumatic brain injury. These recent advancements showcase ongoing efforts to understand and mitigate the devastating effects of this type of injury, offering hope for improved outcomes and quality of life for affected individuals.