Reviewed by Michael Gill, B. Sc.
25 Cervical Cancer Clinical Trials Near Me
Top Hospitals for Cervical Cancer Clinical Trials
Image of M D Anderson Cancer Center in Texas.
M D Anderson Cancer Center
Houston
8Active Trials
32All Time Trials for Cervical Cancer
2005First Cervical Cancer Trial
Image of Memorial Sloan Kettering Cancer Center in New York.
Memorial Sloan Kettering Cancer Center
New York
6Active Trials
16All Time Trials for Cervical Cancer
1994First Cervical Cancer Trial
Top Cities for Cervical Cancer Clinical Trials
Cervical Cancer Clinical Trials by Phase of Trial
Phase < 1 Cervical Cancer Clinical Trials
6Active Cervical Cancer Clinical Trials
6Number of Unique Treatments
7Number of Active Locations
HB-201 ITProflavinePerflubutane Microbubble18F-FTXRadiation TherapyPositron Emission Tomography
Cervical Cancer Clinical Trials by Age Group
18+ Cervical Cancer Clinical Trials
84Active Cervical Cancer Clinical Trials
TelaglenastatKK-LC-1 TCR-T cellsSGN-ALPVPembrolizumab/Vibostolimab Co-FormulationRMC-5552SGN-STNVtrastuzumabHPV Self-Sampling
Top Treatments for Cervical Cancer Clinical Trials
Treatment Name
Active Cervical Cancer Clinical Trials
All Time Trials for Cervical Cancer
First Recorded Cervical Cancer Trial
Pembrolizumab
4
14
2016
Cisplatin
3
72
2001
pembrolizumab
2
2
2015
Atezolizumab
2
8
2017
XmAb20717
2
2
2018
Recently Completed Studies with FDA Approved Treatments for Cervical Cancer
Treatment
Year
Sponsor
AK104
2020
Akeso
Bosutinib
2019
Nagla Abdel Karim
tisotumab vedotin
2018
Seagen Inc.
simlukafusp alfa
2018
Hoffmann-La Roche
AGEN1884 + AGEN2034
2017
Agenus Inc.
AGEN2034
2017
Agenus Inc.

What Are Cervical-Cancer Clinical Trials

Cervical cancer is when cells of the cervix adversely change. The cancer is typically a result of an infection with HPV (human papillomavirus). It is generally diagnosed after a Pap smear (Papanicolaou test).

Cervical cancer rarely produces symptoms at the early stages.

Cervical cancer is primarily either adenocarcinoma or squamous cell carcinoma (the most common).

In the 1970s, the HPV virus was detected by Dr. Harald zur Hausen, who went on to show that an HPV infection is related to cervical cancer. Clinical trials for cervical cancer primarily focus on treatments and early detection techniques.

Why Is Cervical-Cancer Being Studied Through Clinical Trials?

According to the CDC, cervical-cancer impacts 13,000 new people in the United States each year. The World Health Organization ranks it the fourth most common cancer in women, estimating that 570,000 women were diagnosed in 2018.

According to WHO, cervical cancers are some of the most treatable types of cancer, provided it is detected early. Thus, many clinical trials focus on improving early detection techniques. At present, Pap tests are the primary screening method. However, HPV DNA testing is also used. Some clinical trials are looking into new and improved HPV testing.

However, once cervical cancer has become persistent, treatments have traditionally only had a success rate of around 50%. Clinical trials are looking at ways to raise the percentage of positive outcomes.

Prevention of HPV infection is a crucial component of reducing cervical cancer. 2006 was the first time the FDA approved an HPV vaccine for teen girls and young women.

By 2021, 50% of the world was using an HPV vaccine, and many European countries had expanded their vaccination program to include boys. Consequently, the CDC has seen an 88% reduction in genital warts in teen girls and 81% in adult women, alluding to fewer HPV infections.

What Are The Types Of Treatments Available For Cervical-Cancer?

Cervical cancer is primarily treated by surgery when caught in the early stages. However, those diagnosed later often require chemotherapy and or radiation.

However, targeted treatments are emerging. 2021, tisotumab, an antibody drug, was approved by the FDA. 2021 was also when the KEYNOTE-826 trial published promising results for adding immunotherapy to treatment for patients with more advanced stages of cervical cancer.

Clinical trials for immunotherapy examine their safety, the percentage of improvement over chemotherapy alone, and if combining types of immunotherapies raises positive outcomes.

What Are Some Recent Breakthrough Clinical Trials For Cervical-Cancer?

2021: Immunotherapy, Pembrolizumab: Merck & Co funded the Phase 3 KEYNOTE-826 trial. It looked into using Keytruda (pembrolizumab) with chemotherapy as a treatment for patients with metastatic or recurrent cervical cancer. The double-blind trial involved 617 patients. The study showed positive outcomes went from 48%-50% to 66%.

2021: Immunotherapy, Balstilimab – Agenus Inc funded a study where researchers from various Gynecologic divisions, including James Comprehensive Cancer Center, Massey Cancer Center, and Oklahoma Cancer center, examined using balstilimab alone or with zalifrelimab, which work at different immune checkpoints. It is an approach that has been effectively used with other cancers.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 2nd, 2021

Last Reviewed: November 19th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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