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Dynamic FAZA PET and Multiparametric MR Imaging for Brain Tumor

Phase < 1

Waitlist Available

Led By Caroline Chung

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Cervical Cohort: Adult females (>18 years old) with newly diagnosed cervical cancer who are able to provide informed consent, receiving surgery, radiotherapy, or chemotherapy, and have no contraindications to MRI with gadolinium contrast or 18F-FAZA PET

Glioma Cohort: Adult patients (> 18 years old) with newly diagnosed or recurrent high grade glioma with newly confirmed pathology (within 1 month) who are able to provide informed consent and have no contraindications to MRI with gadolinium contrast or 18F-FAZA PET

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 1 year

Awards & highlights

Study Summary

This trial is investigating if brain tumors with greater hypoxia, as defined by qBOLD and 18F-FAZA PET, have certain pathological features including proportionate necrosis, Ki-67 and IDH mutation status.

Who is the study for?

This trial is for adults over 18 with high grade glioma (brain tumor) or newly diagnosed cervical cancer. Participants must be receiving surgery, radiotherapy, or chemotherapy and have no issues with MRI or PET scans using specific contrasts. They should be able to give informed consent.Check my eligibility

What is being tested?

The study is testing the use of dynamic FAZA PET scans and multiparametric MR imaging to evaluate oxygen levels, metabolism, and blood supply in brain tumors and cervical cancers. It aims to understand how these factors relate to each other.See study design

What are the potential side effects?

Since this trial involves diagnostic procedures rather than treatments, side effects are minimal but may include discomfort from lying still during imaging and potential reactions to contrast agents used in MRI or PET scans.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am an adult woman with new cervical cancer, getting treatment, and can have MRI or PET scans.

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I am an adult with a new or returning high-grade brain tumor and can undergo MRI and PET scans.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

To correlate the relationship between dynamic MRI (tumor perfusion (DSC) and permeability (DCE)) and dynamic 18F-FAZA PET uptake.

Trial Design

1Treatment groups

Experimental Treatment

Group I: 18F-FTXExperimental Treatment1 Intervention

The radioactive tracer (FAZA)

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,969 Previous Clinical Trials

1,786,885 Total Patients Enrolled

Caroline ChungPrincipal InvestigatorM.D. Anderson Cancer Center

4 Previous Clinical Trials

254 Total Patients Enrolled

Media Library

18F-FTX Clinical Trial Eligibility Overview. Trial Name: NCT05047913 — Phase < 1

Cervical Cancer Research Study Groups: 18F-FTX

Cervical Cancer Clinical Trial 2023: 18F-FTX Highlights & Side Effects. Trial Name: NCT05047913 — Phase < 1

18F-FTX 2023 Treatment Timeline for Medical Study. Trial Name: NCT05047913 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients being signed up for this trial right now?

"No, this particular clinical trial is not recruiting patients right now. The last update on the study was on August 31st, 2022 and it was first posted on September 20th, 2021. Although this study is not looking for participants, there are currently 503 other clinical trials that are."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

2021. "Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05047913.

All > Cervical Cancer