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CHORUS+ Program for Opioid Use Disorder (CHORUS+ Trial)

N/A

Waitlist Available

Led By Sabrina A Assoumou, MD MPH

Research Sponsored by Boston Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months, 6 months, and 12 months

Awards & highlights

CHORUS+ Trial Summary

This trial seeks to determine if a new combination of HIV self-testing, PrEP, MOUD and peer recovery coaching can increase uptake and adherence to HIV prevention and treatment of opioid use disorder.

Who is the study for?

This trial is for English-speaking individuals in the Boston area who have used opioids by injection within the last 6 months and plan to stay local for half a year. They must be willing to share contacts of two relatives or friends, sign medical records release forms, and not have HIV or intent to harm themselves or others.Check my eligibility

What is being tested?

The CHORUS+ intervention is being tested against standard care. It includes peer-delivered support, mobile phone assistance, HIV self-testing, rapid start of PrEP (HIV prevention medication) and MOUD (medication for opioid use disorder), plus six months of coaching to stick with these treatments.See study design

What are the potential side effects?

While this study isn't testing PrEP's efficacy which is established, side effects can include stomach issues, headaches, fatigue. For MOUDs like methadone or buprenorphine: drowsiness, constipation may occur.

CHORUS+ Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months, 6 months, and 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months, 6 months, and 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months, 6 months, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adherence to HIV PrEP at 6 months Adherence to HIV PrEP

Secondary outcome measures

Adherence to PrEP at 3 and 12 months

Receipt of medication for opioid use disorder (MOUD)

Test results for chlamydia

+2 more

CHORUS+ Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: CHORUS+Experimental Treatment1 Intervention

The baseline questionnaire for participants in this arm will be followed by a 30-minute motivational interviewing (MI) session with the peer recovery coach (PRC), and will assess readiness for change and provide information about PrEP. The PRC will also assess readiness for MOUD, and this will be further explored during subsequent visits.

Group II: Usual care- controlActive Control1 Intervention

Participants in this arm will receive passive referral for care. there will be no PRC MI session and they will not be offered PrEP or MOUD.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Victory Programs Mobile Prevention Services Van and Navigation CenterUNKNOWN

Boston Medical CenterLead Sponsor

382 Previous Clinical Trials

869,115 Total Patients Enrolled

National Institute on Drug Abuse (NIDA)NIH

2,465 Previous Clinical Trials

2,618,349 Total Patients Enrolled

Media Library

CHORUS+ Clinical Trial Eligibility Overview. Trial Name: NCT05769218 — N/A

Opioid Use Disorder Research Study Groups: Usual care- control, CHORUS+

Opioid Use Disorder Clinical Trial 2023: CHORUS+ Highlights & Side Effects. Trial Name: NCT05769218 — N/A

CHORUS+ 2023 Treatment Timeline for Medical Study. Trial Name: NCT05769218 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any current openings to join this clinical trial?

"Reports on clinicaltrials.gov clarify that this research project is no longer recruiting patients, last edited on March 3rd 2023 after its initial posting date of May 1st 2023. However, there are 533 other medical trials actively seeking enrollees presently."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Comprehensive HIV, Hepatitis C, and Opioid Use Disorder Response to the Unaddressed Syndemic +

2024. "Comprehensive HIV, Hepatitis C, and Opioid Use Disorder Response to the Unaddressed Syndemic +". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05769218.

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