Exercise for Aging

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Aging
Exercise - Other
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will look at how different age groups handle fatigue during exercise, and whether a specific type of training can help older adults improve their muscle power output and handle fatigue better.

Treatment Effectiveness

Study Objectives

8 Primary · 1 Secondary · Reporting Duration: Before and 2-days after completion of resistance training intervention of 8 weeks.

Week 8
Change in muscle metabolism during a fatiguing knee extensor exercise from baseline to after 8 weeks resistance training
Week 8
Change in muscle volume of the quadricep muscles form baseline to after 8 weeks training
Change in single muscle fiber function form baseline to after 8 weeks training
Week 8
Change in Oxygenation of the muscle between baseline to after 8 weeks of training
Change in arteriole Vasodilation from baseline to after 8 weeks of training
Change in myofibrillar-ATPase efficiency from baseline to after 8 weeks of training
Strength
Week 8
Change in vascular function via flow-mediated dilation of the femoral artery from baseline to after 8 weeks of training
Week 8
Change in Fatigability of the knee extensor muscles from baseline to after 8 weeks training

Trial Safety

Trial Design

2 Treatment Groups

Blood Flow Restriction Training
1 of 2
Resistance Training Only
1 of 2

Experimental Treatment

120 Total Participants · 2 Treatment Groups

Primary Treatment: Exercise · No Placebo Group · N/A

Blood Flow Restriction Training
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: Other
Resistance Training Only
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: before and 2-days after completion of resistance training intervention of 8 weeks.

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,383 Previous Clinical Trials
3,447,479 Total Patients Enrolled
136 Trials studying Aging
72,559 Patients Enrolled for Aging
Medical College of WisconsinOTHER
554 Previous Clinical Trials
1,152,052 Total Patients Enrolled
2 Trials studying Aging
294 Patients Enrolled for Aging
Marquette UniversityLead Sponsor
54 Previous Clinical Trials
202,040 Total Patients Enrolled
2 Trials studying Aging
490 Patients Enrolled for Aging

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 27th, 2021

Last Reviewed: November 28th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.