This trial is evaluating whether Ultra-fractionated radiation therapy will improve 1 primary outcome and 3 secondary outcomes in patients with Uterine Cervical Neoplasms. Measurement will happen over the course of 90 days.
This trial requires 30 total participants across 1 different treatment group
This trial involves a single treatment. Ultra-fractionated Radiation Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"Causes include environmental and genetic factors, smoking, and some cancers of the reproductive tract. Data from a recent study suggest that women should be monitored for cancer of the uterine cervix." - Anonymous Online Contributor
"The risk of metastatic spread depends on the stage of the uterine cervical lesion at the time of diagnosis and the type of surgical intervention." - Anonymous Online Contributor
"Most women were offered standard conservative treatments, such as cytotoxic chemotherapy or radiotherapy, which are associated with considerable side effects. This is not well-known to women, and could be a source of distress." - Anonymous Online Contributor
"Uterine cervical neoplasms accounted for 15.8% of all cervical malignancies. The histologically detected uterine cervical carcinoma formed the majority of this group (87%). Tumours caused by high-grade squamous intraepithelial neoplasm were the most frequent group (32.3%) followed by high-grade glycogen-rich adenocarcinoma (27.1%). The remainder were differentiated squamous carcinoma with glandular component (11.4%), adenosquamous carcinoma (6.7%) and adenosquamous cell carcinoma (2.8%)." - Anonymous Online Contributor
"The incidence of cervical cancer incidence of the United States is decreasing for the first time, but the prevalence is increasing to such a high rate as to become an important public health concern, a change that has the potential to have a major impact on the survival of many women in the near future." - Anonymous Online Contributor
"Signs of uterine disease can be detected by using a simple clinical evaluation. Urine analysis is an easy and useful technique for assessing for dysphemics, such as urgency or residual blood in the urine. The most helpful method in diagnosing a uterine neoplasm is the biopsy combined with a pelvic examination of the patient." - Anonymous Online Contributor
"The benefit of adjuvant chemotherapy in patients with cervical cancer justifies its use not only in those who receive radiation but also in those receiving primary radiotherapy. Because radiotherapy is the sole modality commonly used in treatment of uterine cervical neoplasms, patients who are treated by primary radiotherapy can be considered as optimal candidates for clinical trials." - Anonymous Online Contributor
"There are more than 100 reports about IF-RT in the scientific literature, but there are only a few (10 to 11) reviews in which a meta-analysis is included. Given the many reported IF-RT trials (about 1/3 have no randomization), the reviews provided a clear message that IF-RT should not be used as frontline therapy for the aforementioned indications. However, a few studies are reporting positive results for IF-RT in the management of cervical cancer in patients with recurrent disease." - Anonymous Online Contributor
"For patients with uterine cervical carcinoma treated with radical radiation therapy, improvement in general and specific functional health-related quality of life after treatment was not evident. The treatment-related distress did not translate into impaired quality of life after adjusting for other explanatory factors." - Anonymous Online Contributor
"A phase III clinical trial is evaluating UFRT compared with a non-placebo therapy for patients with uterine cervical [non-small cell] cancer. The study was initiated following a phase I clinical trial with comparable results." - Anonymous Online Contributor
"The treatments mentioned in a number of recent reviews may be useful, but there are no definitive treatments that have been approved for patients with low grade dysplasia." - Anonymous Online Contributor
"UFT RT-related AEs are common with incidences similar to conventional RT. AEs are rarely severe for all dosages. Severe AEs can be minimized by reducing RT doses and/or expanding eligibility for lower doses of RT." - Anonymous Online Contributor