Reviewed by Michael Gill, B. Sc.
25 Pcos Clinical Trials Near Me
Top Hospitals for Pcos Clinical Trials
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University of Virginia
6Active Trials
7All Time Trials for Pcos
2000First Pcos Trial
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University of Virginia Center for Research in Reproduction
4Active Trials
8All Time Trials for Pcos
2006First Pcos Trial
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Oklahoma City
2Active Trials
University of OklahomaTop Active Site
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What Are PCOS Clinical Trials?

PCOS is a common health problem in women; however, it is a common and treatable cause of infertility. Women with PCOS face hormonal imbalances and metabolism problems that affect their appearance and overall health. In this condition, the ovaries produce an abnormal amount of androgens, which are male sex hormones present in women in small amounts. Some women develop fluid-filled sacs, called cysts, in their ovaries, while some don’t.

Since the cause of PCOS is unclear, many PCOS clinical trials study different drugs and therapies and analyze their effectiveness against the condition.

Why Is PCOS Being Studied Through Clinical Trials?

The global prevalence of PCOS is estimated between 4% and 20%. In contrast, the World Health Organization (WHO) data suggests that approximately 116 million women (3.4%) are affected by PCOS globally. The reasons for PCOS development are not yet clearly identified. Researchers suggest that multiple factors, such as hereditary, lifestyle, and environmental, can contribute to the condition.

Women with PCOS face irregular or anovulatory cycles with signs of hyperandrogenism, such as acne, seborrhea, hirsutism, alopecia, and polycystic ovaries on pelvic sonography. Patients also experience mood swings, weight gain, and pregnancy-related issues.

What Are The Types of Treatments Available For PCOS?

Many ongoing studies are available for PCOS, testing different drugs and their effectiveness. As stated above, the fundamental pathological defect of PCOS is unknown, but we do know that it is characterized by insulin resistance and compensatory hyperinsulinemia. A study evaluates the safety and effectiveness of 3 drugs: clomiphene, citrate, and metformin XR, in achieving a successful pregnancy in infertile PCOS women.

Other studies compare and analyze the clinical outcomes between treatments, such as hCG-primed IVM protocol and minimal stimulation IVF with Gonadotropin-releasing hormone (GnRH) antagonist protocol in women with PCOS in fresh cycles.

What Are Some Recent Breakthrough Clinical Trials For PCOS?

2019: Myo-Inositol/D-Chiro-Inositol Plasma Ratio - this clinical trial directly compared the efficacy of seven different ratios between MI and DCI in PCOS therapy. The authors found that the 40 : 1 MI/DCI ratio was the best for PCOS therapy directed at restoring ovulation and important normalizing parameters (progesterone, LH, SHBG, estradiol, and testosterone) in those patients.

2021: Caesalpinia bonduc (L.) Roxb. - this study reviewed the potential of Caesalpinia bonducella in treating the significant symptoms of PCOS. Phytochemicals in C. bonducella are effective against several ailments attributed to PCOS. However, there are no experiments done in PCOS animal models to claim the direct application of C. bonducella in PCOS treatment.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting PCOS Clinical Trial Research?

UCSF Center Of Reproductive Health

The UCSF Polycystic Ovary Syndrome (PCOS) Multidisciplinary Clinic and Research Center has made great strides in optimizing health and quality of life in women with PCOS. They have developed individualized treatment plans, drug therapies, and lifestyle interventions.

Andrea Dunaif, M.D.

Andrea Dunaif, M.D., is the System Chief of the Division of Endocrinology, Diabetes, and Bone Disease for the Mount Sinai Health System. Her research on polycystic ovary syndrome (PCOS) has shown that it is a leading risk factor for type 2 diabetes mellitus.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 2nd, 2021

Last Reviewed: November 18th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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