Exercise for PCOS & Insulin Resistance

Age: 18 - 65

Sex: Female

Trial Phase: Academic

Sponsor: University of California, San Francisco

Disqualifiers: Diabetes, Hypertension, Cardiovascular, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

Duration: 8 weeks

47 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study evaluates the feasibility and metabolic effects of implementing a structured exercise program in women with polycystic ovary syndrome and insulin resistance. Participants will be randomized to either 75 minutes of vigorous exercise or 150 minutes of moderate exercise per week.

Who Is on the Research Team?

Heather Huddleston, MD

Principal Investigator

University of California, San Francisco

Are You a Good Fit for This Trial?

Women with PCOS and insulin resistance can join this study if they're in good physical shape, have a confirmed diagnosis of PCOS, and show signs of insulin resistance. They must not be pregnant or planning pregnancy soon, over 50 or under 18 years old, severely obese, smokers, or have certain health conditions like diabetes type 2.

Inclusion Criteria

Physician judges that patient is in adequate physical condition to complete exercise program

You have been diagnosed with PCOS according to the 2003 Rotterdam criteria.

Your body has trouble using insulin, which is a hormone that helps control blood sugar levels.

Exclusion Criteria

Current pregnancy or planning to attempt to conceive in the next 3 months

You have a very high body mass index (BMI).

You are currently a smoker.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to either 15 minutes of vigorous exercise (HIIT) or 30 minutes of moderate exercise (brisk walking) to be performed 5 days per week for 8 weeks

8 weeks

Baseline, 4 weeks, 8 weeks

Follow-up

Participants are monitored for changes in insulin resistance and metabolic parameters after the exercise program

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Moderate Exercise
• Vigorous Exercise

Trial Overview The trial is testing how feasible it is for women with PCOS to stick to an exercise program and what effects it has on their metabolism. Participants will do either vigorous exercise for 75 minutes weekly or moderate exercise for 150 minutes weekly.

How Is the Trial Designed?

Group I: Vigorous Exercise Experimental Treatment 1 Intervention

High-intensity interval training for 15 minutes daily, 5 days per week for 8 weeks

Group II: Moderate Exercise Experimental Treatment 1 Intervention

Brisk walking for 30 minutes daily, 5 days per week for 8 weeks

Who Is Running the Clinical Trial?

University of California, San Francisco

Lead Sponsor

Trials

2,636

Recruited

19,080,000+