Exercise for PCOS & Insulin Resistance
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different types of exercise affect women with polycystic ovary syndrome (PCOS) and insulin resistance. It compares two groups: one engaging in vigorous exercise and the other in moderate exercise, to assess the impact on health and metabolism. Women diagnosed with PCOS and showing signs of insulin resistance, such as elevated fasting insulin levels, might be suitable candidates. The goal is to determine which exercise routine is more beneficial for managing these conditions. As an unphased trial, this study provides participants the chance to contribute to valuable research that could enhance exercise recommendations for women with PCOS.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that exercise is generally safe for women with polycystic ovary syndrome (PCOS). Studies have found that moderate activities, like brisk walking, improve fitness and reduce waist size without major issues. More intense exercises, such as high-intensity interval training (HIIT), offer even greater benefits for fitness and reducing the risk of metabolic problems. However, some studies suggest that short-term exercise programs might not significantly change metabolism for everyone.
Overall, both moderate and vigorous exercise programs are usually safe and don't report severe side effects when done correctly. Regular exercise is important for managing PCOS, as it aids in fitness and metabolic health. Consulting a healthcare provider before starting any new exercise routine is essential, especially if existing health concerns are present.12345Why are researchers excited about this trial?
Researchers are excited about the exercise treatments for PCOS and insulin resistance because they offer a natural, side-effect-free alternative to medications like metformin and hormonal therapies. The vigorous exercise approach, involving high-intensity interval training, has the potential to improve insulin sensitivity more rapidly and effectively than traditional exercise regimens. Meanwhile, the moderate exercise treatment, consisting of brisk walking, provides a more accessible option for those who may find high-intensity workouts challenging. Both methods focus on improving metabolic health through physical activity, which could empower individuals with PCOS to manage their condition through lifestyle changes.
What evidence suggests that this trial's exercise programs could be effective for PCOS and insulin resistance?
This trial will compare the effects of different exercise intensities on insulin resistance in women with polycystic ovary syndrome (PCOS). Research has shown that intense exercise, such as the high-intensity interval training used in the vigorous exercise arm of this trial, can significantly improve insulin handling. One study found that women who engaged in intense exercise experienced better insulin sensitivity and improved fitness levels. Another study revealed that just 60 minutes of intense activity per week reduced the risk of metabolic syndrome by 22%.
The moderate exercise arm of this trial involves brisk walking, which also offers benefits. Studies indicate that moderate exercise can improve fitness, reduce waist size, and enhance insulin sensitivity in women with PCOS. Both exercise types can help manage symptoms, but intense exercise might provide more noticeable benefits.13567Who Is on the Research Team?
Heather Huddleston, MD
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
Women with PCOS and insulin resistance can join this study if they're in good physical shape, have a confirmed diagnosis of PCOS, and show signs of insulin resistance. They must not be pregnant or planning pregnancy soon, over 50 or under 18 years old, severely obese, smokers, or have certain health conditions like diabetes type 2.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either 15 minutes of vigorous exercise (HIIT) or 30 minutes of moderate exercise (brisk walking) to be performed 5 days per week for 8 weeks
Follow-up
Participants are monitored for changes in insulin resistance and metabolic parameters after the exercise program
What Are the Treatments Tested in This Trial?
Interventions
- Moderate Exercise
- Vigorous Exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor