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Procedure

Cryoanalgesia for Post-VATS Pain (CRYO-VATS Trial)

N/A

Recruiting

Led By Alex Moore, MD

Research Sponsored by Centre hospitalier de l'Université de Montréal (CHUM)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour, 6 hours, 12 hours, 18 hours, 24 hours, 48 hours and 7 days

Awards & highlights

CRYO-VATS Trial Summary

This trial aims to show the effectiveness of a cryotherapy technique to provide pain relief after lung surgery.

Who is the study for?

This trial is for patients scheduled for elective lung cancer surgery (like removing a part of the lung) using VATS, with an ASA score indicating they are fit for anesthesia and surgery. It's not suitable for those outside this group.Check my eligibility

What is being tested?

The study tests if adding intercostal cryoanalgesia to a single paravertebral block can better manage pain after VATS lung resection compared to just the block alone.See study design

What are the potential side effects?

Cryoanalgesia may cause localized numbness, skin changes, or nerve damage. The paravertebral block could lead to discomfort at injection site, bleeding, infection, or rarely breathing difficulties.

CRYO-VATS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour, 6 hours, 12 hours, 18 hours, 24 hours, 48 hours and 7 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour, 6 hours, 12 hours, 18 hours, 24 hours, 48 hours and 7 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour, 6 hours, 12 hours, 18 hours, 24 hours, 48 hours and 7 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Acute thoracic pain at rest

Acute thoracic pain during cough

Evaluation of sedation related to opioid consumption

+7 more

CRYO-VATS Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intercostal cryoanalgesia AND single-injection paravertebral blockExperimental Treatment1 Intervention

Videothoracoscopic-guided single-injection paravertebral block at T5 with 0.4 mL/kg of Bupivacaine 0.5% with adrenalin 5 mcg/mL (maximum 40 mL) at the beginning of surgery Cryoanalgesia 5 cm lateral to the neuraxial, on the inferior costal border, CO2 at (-)50C to (-)70C for 2 minutes, repeated on 7 costal levels (T3-T9), after the lung resection and before chest closure.

Group II: Single-injection paravertebral blockActive Control1 Intervention

-Videothoracoscopic-guided single-injection paravertebral block at T5 with 0.4 mL/kg of Bupivacaine 0.5% with adrenalin 5 mcg/mL (maximum 40 mL) at the beginning of surgery

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Centre hospitalier de l'Université de Montréal (CHUM)Lead Sponsor

366 Previous Clinical Trials

129,557 Total Patients Enrolled

Alex Moore, MDPrincipal InvestigatorCentre Hospitalier de l'Universite de Montreal

1 Previous Clinical Trials

80 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any openings available for participants in this exploration?

"Per information on clinicaltrials.gov, this medical trial is recruiting patients at present. The initial posting was made on November 9th 2023 and the most recent update took place a day later."

Answered by AI

What is the total cohort size for this research study?

"Affirmative. As seen on clinicaltrials.gov, this medical investigation, which first opened for recruitment in November of 2023, is now actively looking for subjects. The target goal is to recruit 80 participants from a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection

Alex Moore 2023. "Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05896150.

All > Acute Pain