Overactive Bladder Clinical Trials 2023

What Are Overactive Bladder Clinical Trials?

Overactive bladder syndrome is associated with abnormal urgency, increased urinary frequency, and nocturia. Overactivity of the detrusor muscle, involved in bladder control, is responsible for overactive bladder syndrome. When the nervous signal transmission between the brain and the bladder is disrupted, individuals feel the urge to urinate despite an empty bladder.

Certain medications and hormonal disturbances alter bladder control and result in overactive bladder syndrome. Comorbidities that affect neurological function, such as diabetic neuropathy or multiple sclerosis, increase the risk of overactive bladder syndrome. Similarly, muscular disorders in the lower body affect the functioning of the pelvic floor muscles.

The American Urological Association recommends a comprehensive anamnesis and physical examination to diagnose overactive bladder syndrome. Furthermore, urologists may use a urinalysis, urine culture, cytometry, or postvoid residual testing to diagnose complicated patient cases.

Clinical trials for overactive bladder syndrome explore how to minimize the side effects of existing therapies. Furthermore, researchers attempt to find new, more effective therapies to improve the clinical outcomes for patients with this disorder.

Why Is Overactive Bladder Being Studied Through Clinical Trials?

Overactive bladder syndrome is a highly prevalent condition, affecting millions worldwide. An overactive bladder significantly affects an individual’s quality of life. These patients may feel shame and guilt about their condition and frequently become depressed. Furthermore, elderly patients with overactive bladder syndrome are susceptible to falls because of nocturia.

Therefore, there is an enormous potential for research to improve the lives of individuals afflicted by this condition. Clinical trials offer patients new hope for more effective therapies with fewer side effects.

What Are The Types of Treatments Available For Overactive Bladder?

The first-line management of overactive bladder syndrome is lifestyle modification and behavioral therapy. Physiotherapists work closely with patients to practice bladder training and pelvic floor therapy. Patients are counseled to follow a toilet schedule, manage their fluids and diet, and plan their proximity to restrooms.

Protective garments are recommended for patients with chronic overactive bladder syndrome and urinary incontinence. Alternatively, anticholinergic drugs improve muscle contraction in the pelvic floor to prevent the sensation of urinary urgency. Physicians suggest extended-release formulations and transdermal patches to maintain control of muscles.

Surgeons perform neuromodulation and augmentation cystoplasty in eligible candidates. However, patients unable to receive the surgery may receive peripheral tibial nerve stimulation or intradetrusor injections of botulinum toxin.

What Are Some Recent Breakthrough Clinical Trials For Overactive Bladder?

There have been several noteworthy discoveries made about overactive bladder syndrome in recent years, including the following:

2021: Vibegron as a new treatment for overactive bladder syndrome: Vibegron is a highly selective beta-3 adrenergic agonist that relaxes the detrusor muscle during bladder filling. This decreases urinary urgency when the bladder is empty. This new therapy showed significant efficacy over existing alternatives.

Who Are Some Of The Key Researchers Conducting Overactive Bladder Clinical Trial Research?

Dr. Blavias is a global expert on urological abnormalities, including overactive bladder syndrome. His work in corrective surgery of urological structures is amongst the most groundbreaking and has contributed meaningfully to new treatments for overactive bladder syndrome.