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MTP Block vs Paravertebral Block for Pain Relief in Breast Cancer Surgery

N/A
Recruiting
Led By Ioana Costache, MD
Research Sponsored by Ottawa Hospital Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours
Awards & highlights

Summary

This trial will compare the pain-relieving effects of a MTP block to a thoracic paravertebral block and to no block.

Who is the study for?
This trial is for English or French-speaking individuals scheduled for major breast surgery, with a BMI under 30 and an ASA physical status of I-III. It's not suitable for those who've had previous breast surgery on the same side, have nerve issues in the chest, can't have regional anesthesia, refuse this type of pain control, use opioids regularly, suffer from chronic pain disorders or cannot consent.Check my eligibility
What is being tested?
The study is testing how well a new pain-blocking procedure called MTP block works compared to no intervention (control) and another established method known as thoracic paravertebral block (PVB). Participants will be randomly assigned to one of these three groups during their breast cancer surgery.See study design
What are the potential side effects?
While specific side effects are not listed here, typical risks may include discomfort at the injection site, potential nerve damage or infection from the blocks used in both MTP and PVB procedures. The control group would not experience these since they do not receive these interventions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Postoperative analgesia during the first 24 hours.
Secondary outcome measures
Post-operative quality of recovery during the first 24 hours.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: MTP block groupExperimental Treatment1 Intervention
MTP blocks with 0.5% ropivacaine and epinephrine 2.5 mcg/mL
Group II: PVB groupActive Control1 Intervention
paravertebral blocks with 0.5% ropivacaine and epinephrine 2.5 mcg/mL
Group III: control groupPlacebo Group1 Intervention
local anesthetic infiltration subcutaneous 1% lidocaine

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Local anesthetics, such as those used in the Midpoint Transverse Process to Pleura (MTP) Block, work by blocking sodium channels in nerve cells, preventing the initiation and transmission of pain signals to the brain. This targeted approach is crucial for acute pain patients as it provides effective pain relief at the site of injury or surgery, minimizing the need for systemic pain medications and their associated side effects. Regional anesthesia techniques, including nerve blocks, utilize this mechanism to offer significant pain control during and after surgical procedures.
Feeling the Heat: Evolutionary and Microbial Basis for the Analgesic Mechanisms of Photobiomodulation Therapy.Pathophysiologic Approach to Pain Therapy for Complex Pain Entities: A Narrative Review.Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices.

Find a Location

Who is running the clinical trial?

Ottawa Hospital Research InstituteLead Sponsor
565 Previous Clinical Trials
2,786,023 Total Patients Enrolled
3 Trials studying Acute Pain
1,972 Patients Enrolled for Acute Pain
Ioana Costache, MDPrincipal InvestigatorOttawa Hospital, Ottawa Hospital Research Institute

Media Library

Control Group Clinical Trial Eligibility Overview. Trial Name: NCT03713255 — N/A
Acute Pain Research Study Groups: PVB group, MTP block group, control group
Acute Pain Clinical Trial 2023: Control Group Highlights & Side Effects. Trial Name: NCT03713255 — N/A
Control Group 2023 Treatment Timeline for Medical Study. Trial Name: NCT03713255 — N/A
~27 spots leftby Jul 2025