Liposomal bupivacaine for Postoperative Pain

Phase-Based Progress Estimates
University of Iowa, Iowa City, IAPostoperative PainLiposomal bupivacaine - Drug
18 - 80
All Sexes
What conditions do you have?

Study Summary

This trial is looking for the best way to manage pain after VATS surgery, which is a minimally-invasive surgery for lung conditions.

Treatment Effectiveness

Study Objectives

2 Primary · 5 Secondary · Reporting Duration: Up to 6 months post procedure.

Month 6
Measure post-operative opioid consumption following discharge from the hospital
Measure post-operative pain scores after discharge from the hospital
Up to 7 days
Calculate length of hospital stay
Record the return to normal bowel function
Hour 72
Measure lung function
Measure post-operative acute pain scores
Measure post-operative opioid usage

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

1 of 2
Liposomal bupivacaine
1 of 2

Active Control

Experimental Treatment

128 Total Participants · 2 Treatment Groups

Primary Treatment: Liposomal bupivacaine · No Placebo Group · Phase 2

Liposomal bupivacaine
Experimental Group · 1 Intervention: Liposomal bupivacaine · Intervention Types: Drug
ActiveComparator Group · 1 Intervention: Bupivacaine · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 6 months post procedure.

Who is running the clinical trial?

American Society of Regional AnesthesiaOTHER
4 Previous Clinical Trials
135 Total Patients Enrolled
Rakesh Sondekoppam VijayashankarLead Sponsor
1 Previous Clinical Trials
140 Total Patients Enrolled
1 Previous Clinical Trials
120 Total Patients Enrolled
Yatish Ranganath, MDPrincipal InvestigatorUniversity of Iowa

Eligibility Criteria

Age 18 - 80 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are scheduled to have a surgery called video-assisted thoracoscopic surgery (VATS).
Your body mass index (BMI) is below 40.

Frequently Asked Questions

Is the current research project open to enrollment of individuals over 55 years old?

"The participant requirements for this trial necessitate that patients must be over 18 yet under 80 years of age." - Anonymous Online Contributor

Unverified Answer

How many participants are currently participating in this clinical trial?

"Affirmative, according to this medical study is currently recruiting participants. It was initially posted on February 2nd 2021 and recently updated on September 19th 2022, with a total of 128 patients being sought from one single site." - Anonymous Online Contributor

Unverified Answer

What aims is this medical experiment hoping to achieve?

"The primary outcome of this research is to assess post-operative acute pain scores up to 72 hours after the procedure. Secondary objectives include measuring lung function using an incentive spirometer device, tracking opioid consumption following hospital discharge, and determining total length of hospital stay. The air volume inhaled will be graded on a scale from 0 - 2500 milliliters with higher values indicating greater respiratory function compared to baseline measurements before surgery." - Anonymous Online Contributor

Unverified Answer

To what extent am I eligible to join in this research experiment?

"This clinical trial is seeking 128 individuals with postoperative pain aged between 18 and 80. Notably, prospective participants must be over the age of consent, possess a body mass index below 40, and undergo video-assisted thoracoscopic surgery (VATS)." - Anonymous Online Contributor

Unverified Answer

Have any other studies been conducted involving Liposomal bupivacaine?

"Currently, 108 studies are evaluating the efficacy of Liposomal bupivacaine. 18 trials have reached Phase 3 status and they are being conducted in 143 locations primarily based around Philadelphia, Pennsylvania." - Anonymous Online Contributor

Unverified Answer

Has the Federal Drug Administration given their stamp of approval to Liposomal bupivacaine?

"Liposomal bupivacaine is rated a 2 on the safety scale, as clinical data supports its safety but there is no evidence of efficacy yet." - Anonymous Online Contributor

Unverified Answer

Are there any available vacancies for potential participants in this experiment?

"That is correct. According to, this medical trial has been recruiting patients since February 2nd 2021 and the listing was recently updated on September 19th 2022. 128 participants are being sought from a single site for this experiment." - Anonymous Online Contributor

Unverified Answer

For what conditions has Liposomal bupivacaine been prescribed?

"Liposomal bupivacaine is a commonly-prescribed treatment for permphigus, as well as acute nonspecific tenosynovitis, general anesthesia, and lupus erythematosus cell." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.